| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,545,181 | 65,657,000 | 25.16% | ||
| 2 | BAKER BROS. ADVISORS LP | 2,335,125 | 43,247,000 | 16.57% | ||
| 3 | Polaris Venture Management Co. V, L.L.C. | 1,827,992 | 33,854,000 | 12.97% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,190,044 | 21,356,000 | 8.18% | ||
| 5 | EcoR1 Capital, LLC | 836,860 | 15,499,000 | 5.94% | ||
| 6 | RS INVESTMENT MANAGEMENT CO LLC | 669,237 | 12,394,000 | 4.75% | ||
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | 461,530 | 8,548,000 | 3.28% | ||
| 8 | TIVERTON ASSET MANAGEMENT LLC | 450,000 | 8,334,000 | 3.19% | ||
| 9 | RIVERHEAD CAPITAL MANAGEMENT LLC | 415,377 | 7,693,000 | 2.95% | ||
| 10 | Rock Springs Capital Management LP | 408,496 | 7,565,000 | 2.90% | ||
| 11 | Magnetar Financial LLC | 308,859 | 5,720,000 | 2.19% | ||
| 12 | LORD, ABBETT & CO. LLC | 243,397 | 4,508,000 | 1.73% | ||
| 13 | SPHERA FUNDS MANAGEMENT LTD. | 209,027 | 3,696,000 | 1.42% | ||
| 14 | JPMORGAN CHASE & CO | 186,249 | 3,449,000 | 1.32% | ||
| 15 | FEDERATED HERMES, INC. | 161,300 | 2,987,000 | 1.14% | ||
| 16 | BlackRock Fund Advisors | 158,940 | 2,944,000 | 1.13% | ||
| 17 | VANGUARD GROUP INC | 156,003 | 2,889,000 | 1.11% | ||
| 18 | BVF INC/IL | 134,725 | 2,495,000 | 0.96% | ||
| 19 | GOLDMAN SACHS GROUP INC | 77,513 | 1,436,000 | 0.55% | ||
| 20 | Alyeska Investment Group, L.P. | 75,120 | 1,391,000 | 0.53% | ||
| 21 | MARINER INVESTMENT GROUP LLC | 50,665 | 938,000 | 0.36% | ||
| 22 | PUTNAM INVESTMENTS LLC | 49,664 | 920,000 | 0.35% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 42,764 | 792,000 | 0.30% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 38,453 | 712,000 | 0.27% | ||
| 25 | Bank of New York Mellon Corp | 21,730 | 402,000 | 0.15% | ||
| 26 | BlackRock Investment Management, LLC | 21,634 | 401,000 | 0.15% | ||
| 27 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 11,033 | 204,000 | 0.08% | ||
| 28 | UBS Group AG | 10,750 | 199,000 | 0.08% | ||
| 29 | NORGES BANK | 10,000 | 185,000 | 0.07% | ||
| 30 | TEACHERS ADVISORS, LLC | 8,851 | 164,000 | 0.06% | ||
| 31 | NEW YORK STATE COMMON RETIREMENT FUND | 3,920 | 73,000 | 0.03% | ||
| 32 | Nationwide Fund Advisors | 3,900 | 72,000 | 0.03% | ||
| 33 | AMERICAN INTERNATIONAL GROUP, INC. | 3,540 | 65,561 | 0.03% | ||
| 34 | BLACKROCK ADVISORS LLC | 3,061 | 57,000 | 0.02% | ||
| 35 | MORGAN STANLEY | 2,170 | 40,000 | 0.02% | ||
| 36 | STRS OHIO | 1,900 | 35,000 | 0.01% | ||
| 37 | DEUTSCHE BANK AG\ | 1,452 | 26,000 | 0.01% | ||
| 38 | BARCLAYS PLC | 876 | 16,000 | 0.01% | ||
| 39 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 799 | 15,000 | 0.01% | ||
| 40 | ROYAL BANK OF CANADA | 411 | 8,000 | 0.00% | ||
| 41 | WELLS FARGO & COMPANY/MN | 302 | 6,000 | 0.00% | ||
| 42 | Invesco Ltd. | 251 | 5,000 | 0.00% | ||
| 43 | BANK OF AMERICA CORP /DE/ | 167 | 3,000 | 0.00% | ||
| 44 | CITIGROUP INC | 78 | 1,000 | 0.00% | ||
| 45 | Tower Research Capital LLC (TRC) | 75 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
