| 1 |
FMR LLC |
3,551,596 |
13,993,000 |
24.99% |
|
|
| 2 |
BAKER BROS. ADVISORS LP |
2,137,606 |
8,422,000 |
15.04% |
|
|
| 3 |
Polaris Venture Management Co. V, L.L.C. |
1,827,992 |
7,202,000 |
12.86% |
|
|
| 4 |
RS INVESTMENT MANAGEMENT CO LLC |
1,579,892 |
6,225,000 |
11.12% |
|
|
| 5 |
Gruss Capital Management LP |
600,000 |
2,364,000 |
4.22% |
|
|
| 6 |
PRICE T ROWE ASSOCIATES INC /MD/ |
520,452 |
2,051,000 |
3.66% |
|
|
| 7 |
Alyeska Investment Group, L.P. |
490,750 |
1,934,000 |
3.45% |
|
|
| 8 |
BlackRock Fund Advisors |
464,476 |
1,830,000 |
3.27% |
|
|
| 9 |
Rock Springs Capital Management LP |
433,496 |
1,708,000 |
3.05% |
|
|
| 10 |
TIVERTON ASSET MANAGEMENT LLC |
425,147 |
1,675,000 |
2.99% |
|
|
| 11 |
RIVERHEAD CAPITAL MANAGEMENT LLC |
397,783 |
1,568,000 |
2.80% |
|
|
| 12 |
JPMORGAN CHASE & CO |
372,850 |
1,469,000 |
2.62% |
|
|
| 13 |
VANGUARD GROUP INC |
199,631 |
787,000 |
1.41% |
|
|
| 14 |
TANG CAPITAL MANAGEMENT LLC |
190,000 |
749,000 |
1.34% |
|
|
| 15 |
Magnetar Financial LLC |
183,806 |
724,000 |
1.29% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
82,461 |
325,000 |
0.58% |
|
|
| 17 |
EcoR1 Capital, LLC |
74,959 |
295,000 |
0.53% |
|
|
| 18 |
STATE STREET CORP |
68,285 |
270,000 |
0.48% |
|
|
| 19 |
NORTHERN TRUST CORP |
61,708 |
243,000 |
0.43% |
|
|
| 20 |
ALAMBIC INVESTMENT MANAGEMENT, L.P. |
60,396 |
238,000 |
0.43% |
|
|
| 21 |
GREAT POINT PARTNERS LLC |
49,906 |
197,000 |
0.35% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
46,943 |
184,000 |
0.33% |
|
|
| 23 |
GOLDMAN SACHS GROUP INC |
42,753 |
168,000 |
0.30% |
|
|
| 24 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
42,004 |
165,000 |
0.29% |
|
|
| 25 |
Bank of New York Mellon Corp |
36,270 |
143,000 |
0.26% |
|
|
| 26 |
FEDERATED HERMES, INC. |
26,793 |
106,000 |
0.19% |
|
|
| 27 |
RUSSELL FRANK CO/ |
26,700 |
105,000 |
0.19% |
|
|
| 28 |
TFS CAPITAL LLC |
25,887 |
102,000 |
0.18% |
|
|
| 29 |
BlackRock Investment Management, LLC |
21,754 |
86,000 |
0.15% |
|
|
| 30 |
A.R.T. Advisors, LLC |
20,733 |
81,000 |
0.14% |
|
|
| 31 |
UBS Group AG |
19,230 |
76,000 |
0.14% |
|
|
| 32 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
19,386 |
76,000 |
0.14% |
|
|
| 33 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
18,616 |
74,000 |
0.13% |
|
|
| 34 |
ProShare Advisors LLC |
18,115 |
71,000 |
0.13% |
|
|
| 35 |
TD ASSET MANAGEMENT INC |
14,137 |
56,000 |
0.10% |
|
|
| 36 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,961 |
51,000 |
0.09% |
|
|
| 37 |
TEACHERS ADVISORS, LLC |
8,851 |
35,000 |
0.06% |
|
|
| 38 |
CITIGROUP INC |
7,920 |
31,000 |
0.06% |
|
|
| 39 |
NEW YORK STATE COMMON RETIREMENT FUND |
5,500 |
22,000 |
0.04% |
|
|
| 40 |
DEUTSCHE BANK AG\ |
4,704 |
18,000 |
0.03% |
|
|
| 41 |
Nationwide Fund Advisors |
3,900 |
15,000 |
0.03% |
|
|
| 42 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,537 |
14,000 |
0.03% |
|
|
| 43 |
MORGAN STANLEY |
2,785 |
11,000 |
0.02% |
|
|
| 44 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,865 |
9,000 |
0.02% |
|
|
| 45 |
STRS OHIO |
1,900 |
7,000 |
0.01% |
|
|
| 46 |
BLACKROCK ADVISORS LLC |
1,638 |
6,000 |
0.01% |
|
|
| 47 |
BlackRock Japan Co. Ltd |
572 |
2,000 |
0.00% |
|
|
| 48 |
WELLS FARGO & COMPANY/MN |
455 |
2,000 |
0.00% |
|
|
| 49 |
BNP PARIBAS FINANCIAL MARKETS |
94 |
370 |
0.00% |
|
|
| 50 |
Tower Research Capital LLC (TRC) |
1 |
0 |
0.00% |
|
|
