| 1 |
FMR LLC |
3,545,892 |
36,381,000 |
24.06% |
|
|
| 2 |
BAKER BROS. ADVISORS LP |
2,335,125 |
23,958,000 |
15.84% |
|
|
| 3 |
Polaris Venture Management Co. V, L.L.C. |
1,827,992 |
18,755,000 |
12.40% |
|
|
| 4 |
PRICE T ROWE ASSOCIATES INC /MD/ |
1,184,107 |
11,770,000 |
7.78% |
|
|
| 5 |
RS INVESTMENT MANAGEMENT CO LLC |
1,082,249 |
11,104,000 |
7.34% |
|
|
| 6 |
EcoR1 Capital, LLC |
840,462 |
8,623,000 |
5.70% |
|
|
| 7 |
TIVERTON ASSET MANAGEMENT LLC |
472,236 |
4,845,000 |
3.20% |
|
|
| 8 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
461,530 |
4,735,000 |
3.13% |
|
|
| 9 |
RIVERHEAD CAPITAL MANAGEMENT LLC |
415,377 |
4,262,000 |
2.82% |
|
|
| 10 |
Rock Springs Capital Management LP |
388,996 |
3,991,000 |
2.64% |
|
|
| 11 |
JPMORGAN CHASE & CO |
364,173 |
3,736,000 |
2.47% |
|
|
| 12 |
Magnetar Financial LLC |
354,659 |
3,639,000 |
2.41% |
|
|
| 13 |
SPHERA FUNDS MANAGEMENT LTD. |
209,027 |
2,145,000 |
1.42% |
|
|
| 14 |
Alyeska Investment Group, L.P. |
184,177 |
1,890,000 |
1.25% |
|
|
| 15 |
LORD, ABBETT & CO. LLC |
176,754 |
1,814,000 |
1.20% |
|
|
| 16 |
BlackRock Fund Advisors |
162,421 |
1,666,000 |
1.10% |
|
|
| 17 |
FEDERATED HERMES, INC. |
161,300 |
1,655,000 |
1.09% |
|
|
| 18 |
VANGUARD GROUP INC |
152,611 |
1,565,000 |
1.03% |
|
|
| 19 |
BlackRock Institutional Trust Company, N.A. |
81,717 |
838,000 |
0.55% |
|
|
| 20 |
NORTHERN TRUST CORP |
61,855 |
635,000 |
0.42% |
|
|
| 21 |
GOLDMAN SACHS GROUP INC |
59,445 |
610,000 |
0.40% |
|
|
| 22 |
PUTNAM INVESTMENTS LLC |
51,438 |
528,000 |
0.35% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
43,882 |
450,000 |
0.30% |
|
|
| 24 |
BlackRock Investment Management, LLC |
21,232 |
218,000 |
0.14% |
|
|
| 25 |
Bank of New York Mellon Corp |
20,826 |
214,000 |
0.14% |
|
|
| 26 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
19,386 |
199,000 |
0.13% |
|
|
| 27 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
17,688 |
182,000 |
0.12% |
|
|
| 28 |
UBS Group AG |
15,900 |
163,000 |
0.11% |
|
|
| 29 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
11,033 |
113,000 |
0.07% |
|
|
| 30 |
Numeric Investors LLC |
10,753 |
110,000 |
0.07% |
|
|
| 31 |
TEACHERS ADVISORS, LLC |
8,851 |
91,000 |
0.06% |
|
|
| 32 |
PANAGORA ASSET MANAGEMENT INC |
5,918 |
61,000 |
0.04% |
|
|
| 33 |
NEW YORK STATE COMMON RETIREMENT FUND |
5,500 |
56,000 |
0.04% |
|
|
| 34 |
Nationwide Fund Advisors |
3,900 |
40,000 |
0.03% |
|
|
| 35 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,544 |
36,000 |
0.02% |
|
|
| 36 |
BLACKROCK ADVISORS LLC |
3,061 |
31,000 |
0.02% |
|
|
| 37 |
MORGAN STANLEY |
2,100 |
21,000 |
0.01% |
|
|
| 38 |
STRS OHIO |
1,900 |
19,000 |
0.01% |
|
|
| 39 |
DEUTSCHE BANK AG\ |
1,660 |
17,000 |
0.01% |
|
|
| 40 |
BNP PARIBAS FINANCIAL MARKETS |
1,354 |
13,892 |
0.01% |
|
|
| 41 |
Tower Research Capital LLC (TRC) |
1,215 |
12,000 |
0.01% |
|
|
| 42 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
799 |
8,000 |
0.01% |
|
|
| 43 |
PRELUDE CAPITAL MANAGEMENT, LLC |
300 |
3,000 |
0.00% |
|
|
| 44 |
ROYAL BANK OF CANADA |
331 |
3,000 |
0.00% |
|
|
| 45 |
ACADIAN ASSET MANAGEMENT LLC |
168 |
2,000 |
0.00% |
|
|
| 46 |
CITIGROUP INC |
66 |
1,000 |
0.00% |
|
|
| 47 |
WELLS FARGO & COMPANY/MN |
28 |
0 |
0.00% |
|
|
| 48 |
BANK OF AMERICA CORP /DE/ |
20 |
0 |
0.00% |
|
|
| 49 |
BARCLAYS PLC |
31 |
0 |
0.00% |
|
|
