| 1 |
FMR LLC |
3,547,261 |
34,870,000 |
24.46% |
|
|
| 2 |
BAKER BROS. ADVISORS LP |
2,335,125 |
22,954,000 |
16.10% |
|
|
| 3 |
Polaris Venture Management Co. V, L.L.C. |
1,827,992 |
17,969,000 |
12.60% |
|
|
| 4 |
RS INVESTMENT MANAGEMENT CO LLC |
1,206,249 |
11,857,000 |
8.32% |
|
|
| 5 |
PRICE T ROWE ASSOCIATES INC /MD/ |
1,169,007 |
11,491,000 |
8.06% |
|
|
| 6 |
EcoR1 Capital, LLC |
790,462 |
7,770,000 |
5.45% |
|
|
| 7 |
TIVERTON ASSET MANAGEMENT LLC |
465,000 |
4,571,000 |
3.21% |
|
|
| 8 |
BlackRock Fund Advisors |
443,937 |
4,364,000 |
3.06% |
|
|
| 9 |
RIVERHEAD CAPITAL MANAGEMENT LLC |
415,377 |
4,083,000 |
2.86% |
|
|
| 10 |
Rock Springs Capital Management LP |
415,196 |
4,081,000 |
2.86% |
|
|
| 11 |
JPMORGAN CHASE & CO |
375,750 |
3,694,000 |
2.59% |
|
|
| 12 |
Alyeska Investment Group, L.P. |
309,062 |
3,038,000 |
2.13% |
|
|
| 13 |
Magnetar Financial LLC |
186,299 |
1,831,000 |
1.28% |
|
|
| 14 |
VANGUARD GROUP INC |
172,919 |
1,699,000 |
1.19% |
|
|
| 15 |
FEDERATED HERMES, INC. |
161,300 |
1,586,000 |
1.11% |
|
|
| 16 |
LORD, ABBETT & CO. LLC |
108,451 |
1,066,000 |
0.75% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
83,388 |
820,000 |
0.58% |
|
|
| 18 |
NORTHERN TRUST CORP |
61,708 |
607,000 |
0.43% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
47,017 |
462,000 |
0.32% |
|
|
| 20 |
STATE STREET CORP |
44,995 |
444,000 |
0.31% |
|
|
| 21 |
SPHERA FUNDS MANAGEMENT LTD. |
36,450 |
358,000 |
0.25% |
|
|
| 22 |
TD ASSET MANAGEMENT INC |
25,614 |
252,000 |
0.18% |
|
|
| 23 |
UBS Group AG |
22,032 |
216,000 |
0.15% |
|
|
| 24 |
BlackRock Investment Management, LLC |
21,312 |
209,000 |
0.15% |
|
|
| 25 |
Bank of New York Mellon Corp |
20,826 |
205,000 |
0.14% |
|
|
| 26 |
ProShare Advisors LLC |
19,895 |
196,000 |
0.14% |
|
|
| 27 |
CITADEL ADVISORS LLC |
19,891 |
195,000 |
0.14% |
|
|
| 28 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
19,386 |
191,000 |
0.13% |
|
|
| 29 |
ALAMBIC INVESTMENT MANAGEMENT, L.P. |
19,338 |
190,000 |
0.13% |
|
|
| 30 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
18,208 |
179,000 |
0.13% |
|
|
| 31 |
MILLENNIUM MANAGEMENT LLC |
16,694 |
164,000 |
0.12% |
|
|
| 32 |
D. E. Shaw & Co., Inc. |
14,766 |
145,000 |
0.10% |
|
|
| 33 |
GOLDMAN SACHS GROUP INC |
13,351 |
131,000 |
0.09% |
|
|
| 34 |
Numeric Investors LLC |
12,453 |
122,000 |
0.09% |
|
|
| 35 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
11,233 |
110,000 |
0.08% |
|
|
| 36 |
TEACHERS ADVISORS, LLC |
8,851 |
87,000 |
0.06% |
|
|
| 37 |
NEW YORK STATE COMMON RETIREMENT FUND |
5,500 |
54,000 |
0.04% |
|
|
| 38 |
CITIGROUP INC |
5,170 |
51,000 |
0.04% |
|
|
| 39 |
MORGAN STANLEY |
4,723 |
47,000 |
0.03% |
|
|
| 40 |
PRELUDE CAPITAL MANAGEMENT, LLC |
4,638 |
46,000 |
0.03% |
|
|
| 41 |
BANK OF AMERICA CORP /DE/ |
3,942 |
39,000 |
0.03% |
|
|
| 42 |
Nationwide Fund Advisors |
3,900 |
38,000 |
0.03% |
|
|
| 43 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,537 |
35,000 |
0.02% |
|
|
| 44 |
STRS OHIO |
1,900 |
18,000 |
0.01% |
|
|
| 45 |
BLACKROCK ADVISORS LLC |
1,638 |
16,000 |
0.01% |
|
|
| 46 |
DEUTSCHE BANK AG\ |
1,490 |
13,000 |
0.01% |
|
|
| 47 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
799 |
8,000 |
0.01% |
|
|
| 48 |
BNP PARIBAS FINANCIAL MARKETS |
747 |
7,343 |
0.01% |
|
|
| 49 |
BARCLAYS PLC |
459 |
4,000 |
0.00% |
|
|
| 50 |
WELLS FARGO & COMPANY/MN |
13 |
0 |
0.00% |
|
|
