| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | QVT Financial LP | 75,000,000 | 969,000,000 | 74.90% | ||
| 2 | Visium Asset Management, LP | 5,159,160 | 66,656,000 | 5.15% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 5,000,000 | 64,600,000 | 4.99% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 2,532,890 | 32,725,000 | 2.53% | ||
| 5 | D. E. Shaw & Co., Inc. | 1,964,397 | 25,380,000 | 1.96% | ||
| 6 | FRANKLIN RESOURCES INC | 1,406,682 | 18,174,000 | 1.40% | ||
| 7 | FMR LLC | 1,258,781 | 16,263,000 | 1.26% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 990,460 | 12,797,000 | 0.99% | ||
| 9 | PRIMECAP MANAGEMENT CO/CA/ | 774,000 | 10,000,000 | 0.77% | ||
| 10 | JPMORGAN CHASE & CO | 546,436 | 7,059,000 | 0.55% | ||
| 11 | DEERFIELD MANAGEMENT COMPANY, L.P. | 484,664 | 6,262,000 | 0.48% | ||
| 12 | PERCEPTIVE ADVISORS LLC | 410,000 | 5,297,000 | 0.41% | ||
| 13 | Avoro Capital Advisors LLC | 406,470 | 5,252,000 | 0.41% | ||
| 14 | Blackstone Inc. | 353,669 | 4,569,000 | 0.35% | ||
| 15 | BlackRock Fund Advisors | 337,823 | 4,365,000 | 0.34% | ||
| 16 | Asset Management One Co., Ltd. | 272,511 | 3,335,000 | 0.26% | ||
| 17 | CAPSTONE INVESTMENT ADVISORS, LLC | 250,000 | 3,230,000 | 0.25% | ||
| 18 | SG Americas Securities, LLC | 249,291 | 3,221,000 | 0.25% | ||
| 19 | BLACKROCK ADVISORS LLC | 240,389 | 3,105,000 | 0.24% | ||
| 20 | OppenheimerFunds, Inc. | 223,871 | 2,892,000 | 0.22% | ||
| 21 | Vident Investment Advisory, LLC | 167,551 | 2,165,000 | 0.17% | ||
| 22 | DELTEC ASSET MANAGEMENT LLC | 162,417 | 2,098,000 | 0.16% | ||
| 23 | HIGHLAND CAPITAL MANAGEMENT LP | 155,000 | 2,003,000 | 0.15% | ||
| 24 | STATE STREET CORP | 147,967 | 1,912,000 | 0.15% | ||
| 25 | BlackRock Group LTD | 142,600 | 1,842,000 | 0.14% | ||
| 26 | ACUTA CAPITAL PARTNERS, LLC | 140,000 | 1,809,000 | 0.14% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 119,900 | 1,549,000 | 0.12% | Call | |
| 28 | Alyeska Investment Group, L.P. | 113,758 | 1,470,000 | 0.11% | ||
| 29 | BlackRock Institutional Trust Company, N.A. | 104,643 | 1,352,000 | 0.10% | ||
| 30 | LAZARD ASSET MANAGEMENT LLC | 101,925 | 1,316,000 | 0.10% | ||
| 31 | State of New Jersey Common Pension Fund D | 85,000 | 1,098,000 | 0.08% | ||
| 32 | Atika Capital Management LLC | 75,000 | 969,000 | 0.07% | ||
| 33 | Foresite Capital Management II, LLC | 65,000 | 840,000 | 0.06% | ||
| 34 | BlackRock Investment Management, LLC | 61,306 | 792,000 | 0.06% | ||
| 35 | Point72 Asset Management, L.P. | 55,200 | 713,000 | 0.06% | ||
| 36 | NJ State Employees Deferred Compensation Plan | 51,000 | 659,000 | 0.05% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 42,216 | 545,000 | 0.04% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 41,600 | 537,000 | 0.04% | Put | |
| 39 | BlackRock Finance, Inc. | 40,900 | 528,000 | 0.04% | ||
| 40 | Spot Trading L.L.C | 40,300 | 521,000 | 0.04% | Call | |
| 41 | VANGUARD GROUP INC | 37,559 | 485,000 | 0.04% | ||
| 42 | CREDIT SUISSE AG/ | 36,923 | 477,000 | 0.04% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,437 | 445,000 | 0.03% | ||
| 44 | CITADEL ADVISORS LLC | 33,680 | 435,000 | 0.03% | ||
| 45 | Opus Point Partners Management, LLC | 30,722 | 397,000 | 0.03% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,800 | 333,000 | 0.03% | ||
| 47 | SABBY MANAGEMENT, LLC | 21,053 | 272,000 | 0.02% | ||
| 48 | Bank of New York Mellon Corp | 18,683 | 242,000 | 0.02% | ||
| 49 | ROYAL BANK OF CANADA | 17,183 | 222,000 | 0.02% | ||
| 50 | TEACHERS ADVISORS, LLC | 14,349 | 185,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
