| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 24,040,177 | 145,443,000 | 21.31% | ||
| 2 | FMR LLC | 22,025,406 | 133,254,000 | 19.53% | ||
| 3 | Bank of New York Mellon Corp | 10,644,878 | 64,401,000 | 9.44% | ||
| 4 | FRANKLIN RESOURCES INC | 6,644,982 | 40,203,000 | 5.89% | ||
| 5 | GILDER GAGNON HOWE & CO LLC | 6,090,445 | 36,847,000 | 5.40% | ||
| 6 | BlackRock Fund Advisors | 5,295,164 | 32,036,000 | 4.69% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,897,129 | 23,578,000 | 3.46% | ||
| 8 | VANGUARD GROUP INC | 3,808,146 | 23,039,000 | 3.38% | ||
| 9 | STATE STREET CORP | 3,595,957 | 21,754,000 | 3.19% | ||
| 10 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 2,850,833 | 17,247,540 | 2.53% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 2,626,306 | 15,889,000 | 2.33% | ||
| 12 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,223,310 | 13,451,000 | 1.97% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 2,097,803 | 12,692,000 | 1.86% | ||
| 14 | RA CAPITAL MANAGEMENT, L.P. | 1,680,395 | 10,166,000 | 1.49% | ||
| 15 | Tekla Capital Management LLC | 1,481,500 | 8,963,000 | 1.31% | ||
| 16 | GAM Holding AG | 1,275,958 | 7,720,000 | 1.13% | ||
| 17 | NORTHERN TRUST CORP | 1,192,138 | 7,213,000 | 1.06% | ||
| 18 | VHCP Management, LLC | 846,500 | 5,121,000 | 0.75% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 669,092 | 4,048,000 | 0.59% | ||
| 20 | CLOUGH CAPITAL PARTNERS L P | 613,718 | 3,713,000 | 0.54% | ||
| 21 | MORGAN STANLEY | 606,849 | 3,671,000 | 0.54% | ||
| 22 | Ghost Tree Capital, LLC | 600,000 | 3,630,000 | 0.53% | ||
| 23 | STONERIDGE INVESTMENT PARTNERS LLC | 546,057 | 3,304,000 | 0.48% | ||
| 24 | NEW YORK STATE COMMON RETIREMENT FUND | 472,954 | 2,861,000 | 0.42% | ||
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 419,422 | 2,538,000 | 0.37% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 397,290 | 2,404,000 | 0.35% | ||
| 27 | Avoro Capital Advisors LLC | 392,000 | 2,372,000 | 0.35% | ||
| 28 | CITADEL ADVISORS LLC | 388,800 | 2,352,000 | 0.34% | ||
| 29 | SPHERA FUNDS MANAGEMENT LTD. | 365,000 | 2,208,000 | 0.32% | ||
| 30 | BlackRock Investment Management, LLC | 345,946 | 2,093,000 | 0.31% | ||
| 31 | Nicholas Investment Partners, LP | 320,538 | 1,939,000 | 0.28% | ||
| 32 | MORGENS WATERFALL VINTIADIS & CO INC | 280,000 | 1,694,000 | 0.25% | ||
| 33 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 241,838 | 1,463,000 | 0.21% | ||
| 34 | BAMCO INC /NY/ | 234,500 | 1,419,000 | 0.21% | ||
| 35 | STIFEL FINANCIAL CORP | 232,123 | 1,404,000 | 0.21% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 216,524 | 1,310,000 | 0.19% | ||
| 37 | Iguana Healthcare Management, LLC | 200,000 | 1,210,000 | 0.18% | ||
| 38 | MILLENNIUM MANAGEMENT LLC | 189,200 | 1,145,000 | 0.17% | Call | |
| 39 | JPMORGAN CHASE & CO | 185,757 | 1,124,000 | 0.16% | ||
| 40 | GOLDMAN SACHS GROUP INC | 176,904 | 1,070,000 | 0.16% | ||
| 41 | TEACHERS ADVISORS, LLC | 163,914 | 992,000 | 0.15% | ||
| 42 | TD ASSET MANAGEMENT INC | 159,300 | 964,000 | 0.14% | ||
| 43 | ALLIANCEBERNSTEIN L.P. | 136,800 | 828,000 | 0.12% | ||
| 44 | OUTFITTER ADVISORS, LTD. | 110,532 | 669,000 | 0.10% | ||
| 45 | RHUMBLINE ADVISERS | 108,024 | 654,000 | 0.10% | ||
| 46 | COLUMBUS CIRCLE INVESTORS | 87,653 | 530,000 | 0.08% | ||
| 47 | Paloma Partners Management Co | 83,972 | 508,000 | 0.07% | ||
| 48 | SABBY MANAGEMENT, LLC | 83,274 | 504,000 | 0.07% | ||
| 49 | Nationwide Fund Advisors | 81,392 | 492,000 | 0.07% | ||
| 50 | Quantitative Systematic Strategies LLC | 78,698 | 488,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
