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Institutional Investment Manager
SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. (CIK: 0001496201), located at 4 Itzhak Sade Building A, Tel Aviv, L3. Institutional holdings reported to the SEC.

Institutional Holdings (2015Q1)
Portfolio Summary: 147 holdings with a total value of $960,518,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 ISHARES TR 8,000 99,496,000 10.36% Put
2 SPDR S&P 500 ETF TR PUT 3,500 72,251,000 7.52% Put
3 ALLERGAN PLC 192,100 57,173,000 5.95%
4 PFIZER INC 1,024,013 35,625,000 3.71%
5 SPDR S&P BIOTECH ETF 1,500 33,063,000 3.44% Put
6 GILEAD SCIENCES INC 320,000 31,402,000 3.27%
7 TEVA PHARMACEUTICAL INDS LTD 402,819 25,096,000 2.61%
8 ABBVIE INC 407,000 23,826,000 2.48%
9 TEVA PHARMACEUTICAL INDUSTRIES LTD 3,500 21,805,000 2.27% Call
10 MERCK & CO INC 375,000 21,555,000 2.24%
11 AMGEN INC 120,200 19,214,000 2.00%
12 ENDO INTL 210,000 18,837,000 1.96%
13 MYLAN N V 272,100 16,149,000 1.68%
14 AUSPEX PHARMACEUTICALS INC 125,074 12,541,000 1.31%
15 ORMAT TECHNOLOGIES INC 80,092 12,054,000 1.25%
16 AMAG PHARMACEUTICALS INC COM 200,230 10,945,000 1.14%
17 ISHARES TR 300 10,303,000 1.07% Put
18 BIOMARIN 80,000 9,970,000 1.04%
19 NOVARTIS A G 100,000 9,861,000 1.03%
20 SELECT SECTOR SPDR TR SBI HEALTHCARE 1,300 9,425,000 0.98% Put
21 VALEANT PHARMACEUTICALS INTL 45,750 9,087,000 0.95%
22 UNITED THERAPEUTICS 48,840 8,422,000 0.88%
23 CLOVIS ONCOLOGY INC 112,455 8,348,000 0.87%
24 CELGENE CORP 70,000 8,070,000 0.84%
25 VERINT SYS INC COM 122,304 7,574,000 0.79%
26 SHIRE PLC 134,751 7,229,000 0.75%
27 SEATTLE GENETICS INC 200,000 7,070,000 0.74%
28 ISHARES TR 56,100 6,977,000 0.73%
29 ARRAY BIOPHARMA INC COM 923,922 6,809,000 0.71%
30 BRISTOL MYERS SQUIBB CO 100,000 6,450,000 0.67%
31 DYAX CORP COM CVR 367,556 6,158,000 0.64%
32 ASTRAZENECA PLC 86,637 5,929,000 0.62%
33 CHECK POINT SOFTWARE TECH LT 71,927 5,896,000 0.61%
34 INSYS THERAPEUTICS INC NEW COM NEW 100,000 5,813,000 0.61%
35 BELLICUM PHARMACEUTICALS INC COM 249,567 5,693,000 0.59%
36 CONCERT PHARMACEUTICALS INC COM 375,000 5,679,000 0.59%
37 APPLE INC 42,733 5,317,000 0.55%
38 Tekmira Pharmaceuticals Corp. 298,486 5,212,000 0.54%
39 INSMED INC COM PAR .01 250,000 5,200,000 0.54%
40 KAMADA LTD 293,727 5,167,000 0.54%
41 FORWARD PHARMA A/S 180,000 5,098,000 0.53%
42 TOWERS WATSON & CO 38,300 5,063,000 0.53%
43 VANDA PHARMACEUTICALS INC COM 543,390 5,054,000 0.53%
44 AMICUS THERAPEUTICS INC 450,000 4,896,000 0.51%
45 RELYPSA INC 135,000 4,869,000 0.51%
46 CATALYST PHARMACEUTICALS INC 1,100,000 4,763,000 0.50%
47 APPLIED GENETIC TECHNOL CORP 235,124 4,700,000 0.49%
48 IMPAX LABORATORIES INC 100,000 4,687,000 0.49%
49 MEDIVATION INC 36,115 4,661,000 0.49%
50 KYTHERA BIOPHARMACEUTICALS I 90,000 4,514,000 0.47%
Page 1 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001178913-15-001551, filed 2015.05.11).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.