| 1 |
ORBIMED ADVISORS LLC |
6,900,000 |
10,558,000 |
41.12% |
|
|
| 2 |
Novo Holdings A/S |
4,622,032 |
7,072,000 |
27.55% |
|
PRN |
| 3 |
Clearbridge Investments, LLC |
1,960,287 |
2,999,000 |
11.68% |
|
|
| 4 |
Tetragon Partners GP Ltd |
738,994 |
1,131,000 |
4.41% |
|
|
| 5 |
VANGUARD GROUP INC |
662,572 |
1,030,000 |
4.01% |
|
|
| 6 |
683 Capital Management, LLC |
622,434 |
952,000 |
3.71% |
|
|
| 7 |
PURA VIDA INVESTMENTS, LLC |
587,241 |
899,000 |
3.50% |
|
|
| 8 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
166,500 |
266,000 |
1.04% |
|
|
| 9 |
PRICE T ROWE ASSOCIATES INC /MD/ |
132,507 |
203,000 |
0.79% |
|
|
| 10 |
DELTEC ASSET MANAGEMENT LLC |
74,140 |
113,000 |
0.44% |
|
|
| 11 |
HIGHLAND CAPITAL MANAGEMENT LP |
69,326 |
111,000 |
0.43% |
|
|
| 12 |
CSS LLC/IL |
54,980 |
84,000 |
0.33% |
|
|
| 13 |
Yakira Capital Management, Inc. |
38,308 |
59,000 |
0.23% |
|
SH |
| 14 |
DLD ASSET MANAGEMENT, LP |
30,541 |
47,000 |
0.18% |
|
|
| 15 |
PRELUDE CAPITAL MANAGEMENT, LLC |
28,001 |
43,000 |
0.17% |
|
|
| 16 |
MORGAN STANLEY |
26,247 |
40,000 |
0.16% |
|
|
| 17 |
WASHINGTON TRUST Co |
13,941 |
21,000 |
0.08% |
|
|
| 18 |
CITADEL ADVISORS LLC |
12,377 |
20,000 |
0.08% |
|
|
| 19 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
10,876 |
17,000 |
0.07% |
|
|
| 20 |
Tower Research Capital LLC (TRC) |
3,566 |
5,000 |
0.02% |
|
|
| 21 |
BANK OF AMERICA CORP /DE/ |
1,000 |
2,000 |
0.01% |
|
|
| 22 |
Creative Planning |
500 |
1,000 |
0.00% |
|
|
| 23 |
UBS Group AG |
100 |
0 |
0.00% |
|
|
| 24 |
WELLS FARGO & COMPANY/MN |
1 |
0 |
0.00% |
|
|
| 25 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
100 |
0 |
0.00% |
|
|
| 26 |
JPMORGAN CHASE & CO |
97 |
0 |
0.00% |
|
|
