| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,973,851 | 47,726,000 | 37.36% | ||
| 2 | Bain Capital Public Equity Management, LLC | 1,514,082 | 18,184,000 | 14.23% | ||
| 3 | PFM Health Sciences, LP | 1,357,973 | 16,309,000 | 12.77% | ||
| 4 | GOLDMAN SACHS GROUP INC | 594,422 | 7,139,000 | 5.59% | ||
| 5 | VANGUARD GROUP INC | 346,585 | 4,163,000 | 3.26% | ||
| 6 | BlackRock Fund Advisors | 329,661 | 3,959,000 | 3.10% | ||
| 7 | EVENTIDE ASSET MANAGEMENT, LLC | 300,000 | 3,603,000 | 2.82% | ||
| 8 | CASDIN CAPITAL, LLC | 276,500 | 3,321,000 | 2.60% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 235,294 | 2,826,000 | 2.21% | ||
| 10 | JPMORGAN CHASE & CO | 211,200 | 2,537,000 | 1.99% | ||
| 11 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,000 | 2,402,000 | 1.88% | ||
| 12 | Partner Investment Management, L.P. | 162,278 | 1,948,000 | 1.52% | ||
| 13 | STATE STREET CORP | 157,246 | 1,889,000 | 1.48% | ||
| 14 | WELLINGTON MANAGEMENT GROUP LLP | 123,812 | 1,487,000 | 1.16% | ||
| 15 | NORTHERN TRUST CORP | 105,537 | 1,267,000 | 0.99% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 92,183 | 1,107,000 | 0.87% | ||
| 17 | FIDUCIARY TRUST CO | 91,175 | 1,095,000 | 0.86% | ||
| 18 | GLOBEFLEX CAPITAL L P | 90,631 | 1,088,000 | 0.85% | ||
| 19 | ASCEND CAPITAL, LLC | 58,267 | 700,000 | 0.55% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 55,385 | 665,000 | 0.52% | ||
| 21 | BlackRock Investment Management, LLC | 46,753 | 562,000 | 0.44% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 38,936 | 468,000 | 0.37% | ||
| 23 | Bank of New York Mellon Corp | 33,365 | 401,000 | 0.31% | ||
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 26,971 | 324,000 | 0.25% | ||
| 25 | WELLS FARGO & COMPANY/MN | 25,695 | 309,000 | 0.24% | ||
| 26 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 24,811 | 298,000 | 0.23% | ||
| 27 | TEACHERS ADVISORS, LLC | 18,757 | 225,000 | 0.18% | ||
| 28 | EMERALD ACQUISITION LTD. | 14,909 | 179,000 | 0.14% | ||
| 29 | BlackRock Group LTD | 14,401 | 173,000 | 0.14% | ||
| 30 | NEW YORK STATE COMMON RETIREMENT FUND | 12,100 | 145,000 | 0.11% | ||
| 31 | STRS OHIO | 11,600 | 139,000 | 0.11% | ||
| 32 | SG Americas Securities, LLC | 11,195 | 134,000 | 0.10% | ||
| 33 | Virtu KCG Holdings LLC | 10,995 | 132,000 | 0.10% | ||
| 34 | RHUMBLINE ADVISERS | 10,451 | 126,000 | 0.10% | ||
| 35 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 9,375 | 113,000 | 0.09% | ||
| 36 | Nationwide Fund Advisors | 7,461 | 90,000 | 0.07% | ||
| 37 | AMERICAN INTERNATIONAL GROUP, INC. | 6,767 | 81,272 | 0.06% | ||
| 38 | BANK OF MONTREAL /CAN/ | 6,718 | 80,000 | 0.06% | ||
| 39 | BLACKROCK ADVISORS LLC | 6,150 | 74,000 | 0.06% | ||
| 40 | BlackRock Finance, Inc. | 5,927 | 71,000 | 0.06% | ||
| 41 | BANK OF AMERICA CORP /DE/ | 4,555 | 55,000 | 0.04% | ||
| 42 | TLP GROUP LLC | 4,028 | 48,000 | 0.04% | ||
| 43 | Legal & General Group Plc | 2,141 | 26,000 | 0.02% | ||
| 44 | MORGAN STANLEY | 2,149 | 26,000 | 0.02% | ||
| 45 | DEUTSCHE BANK AG\ | 1,930 | 23,000 | 0.02% | ||
| 46 | UBS Group AG | 1,264 | 15,000 | 0.01% | ||
| 47 | Tower Research Capital LLC (TRC) | 1,084 | 13,000 | 0.01% | ||
| 48 | BNP PARIBAS FINANCIAL MARKETS | 795 | 9,548 | 0.01% | ||
| 49 | BlackRock Japan Co. Ltd | 393 | 5,000 | 0.00% | ||
| 50 | BARCLAYS PLC | 74 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
