| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,973,851 | 50,627,000 | 36.61% | ||
| 2 | Bain Capital Public Equity Management, LLC | 1,514,082 | 19,289,000 | 13.95% | ||
| 3 | PFM Health Sciences, LP | 1,384,151 | 17,634,000 | 12.75% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 446,080 | 5,683,000 | 4.11% | ||
| 5 | BlackRock Fund Advisors | 385,055 | 4,906,000 | 3.55% | ||
| 6 | CASDIN CAPITAL, LLC | 385,000 | 4,905,000 | 3.55% | ||
| 7 | VANGUARD GROUP INC | 382,124 | 4,868,000 | 3.52% | ||
| 8 | GOLDMAN SACHS GROUP INC | 307,095 | 3,912,000 | 2.83% | ||
| 9 | EVENTIDE ASSET MANAGEMENT, LLC | 300,000 | 3,822,000 | 2.76% | ||
| 10 | DEERFIELD MANAGEMENT COMPANY, L.P. | 235,294 | 2,998,000 | 2.17% | ||
| 11 | JPMORGAN CHASE & CO | 205,357 | 2,616,000 | 1.89% | ||
| 12 | STATE STREET CORP | 165,503 | 2,108,000 | 1.52% | ||
| 13 | WELLINGTON MANAGEMENT GROUP LLP | 111,862 | 1,425,000 | 1.03% | ||
| 14 | NORTHERN TRUST CORP | 105,757 | 1,347,000 | 0.97% | ||
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 103,055 | 1,313,000 | 0.95% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 91,688 | 1,168,000 | 0.84% | ||
| 17 | FIDUCIARY TRUST CO | 91,175 | 1,162,000 | 0.84% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 57,969 | 738,000 | 0.53% | ||
| 19 | GLOBEFLEX CAPITAL L P | 57,430 | 732,000 | 0.53% | ||
| 20 | BlackRock Investment Management, LLC | 46,753 | 596,000 | 0.43% | ||
| 21 | MORGAN STANLEY | 39,635 | 505,000 | 0.37% | ||
| 22 | WELLS FARGO & COMPANY/MN | 38,978 | 496,000 | 0.36% | ||
| 23 | Bank of New York Mellon Corp | 38,066 | 485,000 | 0.35% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 37,978 | 484,000 | 0.35% | ||
| 25 | HARBOURVEST PARTNERS LLC | 36,362 | 463,000 | 0.33% | ||
| 26 | Partner Investment Management, L.P. | 34,256 | 436,000 | 0.32% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,895 | 356,000 | 0.26% | ||
| 28 | BANK OF MONTREAL /CAN/ | 27,293 | 340,000 | 0.25% | ||
| 29 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 24,111 | 307,000 | 0.22% | ||
| 30 | BESSEMER GROUP INC | 21,818 | 278,000 | 0.20% | ||
| 31 | TEACHERS ADVISORS, LLC | 20,604 | 262,000 | 0.19% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18,705 | 238,000 | 0.17% | ||
| 33 | RUSSELL INVESTMENTS GROUP, LTD. | 14,909 | 194,000 | 0.14% | ||
| 34 | BlackRock Group LTD | 14,401 | 183,000 | 0.13% | ||
| 35 | ABERDEEN ASSET MANAGEMENT PLC/UK | 13,909 | 177,000 | 0.13% | ||
| 36 | NEW YORK STATE COMMON RETIREMENT FUND | 12,100 | 154,000 | 0.11% | ||
| 37 | RHUMBLINE ADVISERS | 11,448 | 146,000 | 0.11% | ||
| 38 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 9,431 | 120,000 | 0.09% | ||
| 39 | Nationwide Fund Advisors | 7,461 | 95,000 | 0.07% | ||
| 40 | HERSHEY TRUST CO | 7,273 | 93,000 | 0.07% | ||
| 41 | AMERICAN INTERNATIONAL GROUP, INC. | 6,748 | 86,000 | 0.06% | ||
| 42 | DEUTSCHE BANK AG\ | 6,803 | 85,000 | 0.06% | ||
| 43 | BLACKROCK ADVISORS LLC | 6,010 | 77,000 | 0.06% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 5,992 | 76,000 | 0.05% | ||
| 45 | STRS OHIO | 5,900 | 75,000 | 0.05% | ||
| 46 | Legal & General Group Plc | 4,052 | 52,000 | 0.04% | ||
| 47 | BlackRock Finance, Inc. | 4,100 | 52,000 | 0.04% | ||
| 48 | UBS Group AG | 3,018 | 38,000 | 0.03% | ||
| 49 | CITIGROUP INC | 1,810 | 23,000 | 0.02% | ||
| 50 | BARCLAYS PLC | 1,800 | 23,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
