| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,322,547 | 172,297,000 | 27.03% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,332,347 | 92,967,000 | 14.58% | ||
| 3 | BAKER BROS. ADVISORS LP | 2,221,706 | 88,557,000 | 13.89% | ||
| 4 | Consonance Capital Management LP | 1,311,855 | 52,291,000 | 8.20% | ||
| 5 | SCOPIA CAPITAL MANAGEMENT LP | 1,231,442 | 49,085,000 | 7.70% | ||
| 6 | OppenheimerFunds, Inc. | 978,650 | 39,009,000 | 6.12% | ||
| 7 | Rock Springs Capital Management LP | 850,000 | 33,881,000 | 5.31% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 625,000 | 24,913,000 | 3.91% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 523,023 | 20,848,000 | 3.27% | ||
| 10 | VIVO CAPITAL, LLC | 483,786 | 19,284,000 | 3.03% | ||
| 11 | Artisan Partners Limited Partnership | 423,719 | 16,889,000 | 2.65% | ||
| 12 | Sio Capital Management, LLC | 108,523 | 4,326,000 | 0.68% | ||
| 13 | Clearbridge Investments, LLC | 87,081 | 3,471,000 | 0.54% | ||
| 14 | Cormorant Asset Management, LP | 75,000 | 2,990,000 | 0.47% | ||
| 15 | MORGAN STANLEY | 72,358 | 2,884,000 | 0.45% | ||
| 16 | DEUTSCHE BANK AG\ | 65,700 | 2,618,000 | 0.41% | ||
| 17 | TD ASSET MANAGEMENT INC | 54,735 | 2,182,000 | 0.34% | ||
| 18 | SCHONFELD STRATEGIC ADVISORS LLC | 50,000 | 1,993,000 | 0.31% | ||
| 19 | ALPS ADVISORS INC | 37,833 | 1,508,000 | 0.24% | ||
| 20 | FEDERATED HERMES, INC. | 33,493 | 1,335,000 | 0.21% | ||
| 21 | STATE STREET CORP | 25,651 | 1,022,000 | 0.16% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 22,095 | 880,000 | 0.14% | ||
| 23 | Virtu KCG Holdings LLC | 8,480 | 338,000 | 0.05% | ||
| 24 | RAYMOND JAMES & ASSOCIATES | 8,359 | 333,000 | 0.05% | ||
| 25 | CLEARBRIDGE, LLC | 8,350 | 333,000 | 0.05% | ||
| 26 | Birchview Capital, LP | 7,000 | 279,000 | 0.04% | ||
| 27 | Laurion Capital Management LP | 6,894 | 275,000 | 0.04% | ||
| 28 | ELLINGTON MANAGEMENT GROUP LLC | 5,400 | 215,000 | 0.03% | ||
| 29 | JPMORGAN CHASE & CO | 4,019 | 160,000 | 0.03% | ||
| 30 | WELLS FARGO & COMPANY/MN | 2,487 | 99,000 | 0.02% | ||
| 31 | UBS Group AG | 1,629 | 65,000 | 0.01% | ||
| 32 | CITIGROUP INC | 1,332 | 53,000 | 0.01% | ||
| 33 | EDMOND DE ROTHSCHILD HOLDING S.A. | 860 | 34,000 | 0.01% | ||
| 34 | BlackRock Finance, Inc. | 500 | 20,000 | 0.00% | ||
| 35 | ADVISOR GROUP, INC. | 207 | 8,000 | 0.00% | ||
| 36 | IFP ADVISORS, INC | 114 | 5,000 | 0.00% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 130 | 5,000 | 0.00% | ||
| 38 | BANK OF MONTREAL /CAN/ | 95 | 4,000 | 0.00% | ||
| 39 | Tradewinds Capital Management, LLC | 77 | 3,000 | 0.00% | ||
| 40 | US BANCORP \DE\ | 39 | 2,000 | 0.00% | ||
| 41 | Cornerstone Advisors, Inc. | 40 | 2,000 | 0.00% | ||
| 42 | ACROSPIRE INVESTMENT MANAGEMENT LLC | 19 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
