| 1 |
FMR LLC |
4,322,547 |
115,671,000 |
31.48% |
|
|
| 2 |
PRICE T ROWE ASSOCIATES INC /MD/ |
2,419,341 |
64,742,000 |
17.62% |
|
|
| 3 |
BAKER BROS. ADVISORS LP |
2,167,137 |
57,993,000 |
15.78% |
|
|
| 4 |
SCOPIA CAPITAL MANAGEMENT LP |
1,782,782 |
47,707,000 |
12.98% |
|
|
| 5 |
Rock Springs Capital Management LP |
930,000 |
24,887,000 |
6.77% |
|
|
| 6 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
814,830 |
21,805,000 |
5.93% |
|
|
| 7 |
VIVO CAPITAL, LLC |
455,798 |
12,197,000 |
3.32% |
|
|
| 8 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
210,000 |
5,620,000 |
1.53% |
|
|
| 9 |
Sio Capital Management, LLC |
153,332 |
4,103,000 |
1.12% |
|
|
| 10 |
Cormorant Asset Management, LP |
124,220 |
3,324,000 |
0.90% |
|
|
| 11 |
Iguana Healthcare Management, LLC |
60,000 |
1,606,000 |
0.44% |
|
|
| 12 |
TD ASSET MANAGEMENT INC |
59,994 |
1,605,000 |
0.44% |
|
|
| 13 |
FEDERATED HERMES, INC. |
49,160 |
1,316,000 |
0.36% |
|
|
| 14 |
ALPS ADVISORS INC |
41,538 |
1,112,000 |
0.30% |
|
|
| 15 |
SCHONFELD STRATEGIC ADVISORS LLC |
30,000 |
803,000 |
0.22% |
|
|
| 16 |
STATE STREET CORP |
22,740 |
608,000 |
0.17% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
16,657 |
445,000 |
0.12% |
|
|
| 18 |
SENZAR ASSET MANAGEMENT, LLC |
14,400 |
385,000 |
0.10% |
|
|
| 19 |
Laurion Capital Management LP |
13,994 |
374,000 |
0.10% |
|
|
| 20 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
12,673 |
339,000 |
0.09% |
|
|
| 21 |
A.R.T. Advisors, LLC |
12,500 |
334,000 |
0.09% |
|
|
| 22 |
CREDIT SUISSE AG/ |
10,772 |
288,000 |
0.08% |
|
|
| 23 |
MORGAN STANLEY |
3,135 |
84,000 |
0.02% |
|
|
| 24 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
2,300 |
62,000 |
0.02% |
|
|
| 25 |
EDMOND DE ROTHSCHILD HOLDING S.A. |
860 |
23,000 |
0.01% |
|
|
| 26 |
WELLS FARGO & COMPANY/MN |
460 |
12,000 |
0.00% |
|
|
| 27 |
BANK OF AMERICA CORP /DE/ |
101 |
3,000 |
0.00% |
|
|
| 28 |
Tradewinds Capital Management, LLC |
77 |
2,000 |
0.00% |
|
|
| 29 |
Cornerstone Advisors, Inc. |
40 |
1,000 |
0.00% |
|
|
| 30 |
US BANCORP \DE\ |
39 |
1,000 |
0.00% |
|
|
| 31 |
ADVISOR GROUP, INC. |
53 |
1,000 |
0.00% |
|
|
