| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAUPOST GROUP LLC/MA | 2,226,839 | 7,660,000 | 30.39% | ||
| 2 | BVF INC/IL | 734,976 | 2,528,000 | 10.03% | ||
| 3 | Foresite Capital Management II, LLC | 622,013 | 2,140,000 | 8.49% | ||
| 4 | VANGUARD GROUP INC | 562,331 | 1,934,000 | 7.67% | ||
| 5 | FORESITE CAPITAL MANAGEMENT III, LLC | 380,530 | 1,309,000 | 5.19% | ||
| 6 | NEA Management Company, LLC | 370,900 | 1,276,000 | 5.06% | ||
| 7 | GLG LLC | 250,172 | 861,000 | 3.42% | ||
| 8 | CREDIT SUISSE AG/ | 234,740 | 808,000 | 3.21% | ||
| 9 | BlackRock Finance, Inc. | 218,793 | 752,000 | 2.98% | ||
| 10 | Old West Investment Management, LLC | 206,687 | 711,000 | 2.82% | ||
| 11 | Rock Springs Capital Management LP | 165,300 | 569,000 | 2.26% | ||
| 12 | Rhenman & Partners Asset Management AB | 120,000 | 413,000 | 1.64% | ||
| 13 | EcoR1 Capital, LLC | 117,726 | 405,000 | 1.61% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 116,900 | 402,000 | 1.59% | Put | |
| 15 | CITIGROUP INC | 114,980 | 396,000 | 1.57% | Call | |
| 16 | BANK OF MONTREAL /CAN/ | 88,500 | 304,000 | 1.21% | ||
| 17 | BANK OF MONTREAL /CAN/ | 88,500 | 304,000 | 1.21% | Put | |
| 18 | Telemetry Investments, L.L.C. | 88,269 | 304,000 | 1.21% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 66,120 | 227,000 | 0.90% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47,713 | 164,000 | 0.65% | ||
| 21 | WELLS FARGO & COMPANY/MN | 44,538 | 153,000 | 0.61% | ||
| 22 | Virtu KCG Holdings LLC | 43,954 | 151,000 | 0.60% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,900 | 134,000 | 0.53% | Call | |
| 24 | MORGAN STANLEY | 38,455 | 131,000 | 0.52% | ||
| 25 | GOLDMAN SACHS GROUP INC | 35,791 | 123,000 | 0.49% | ||
| 26 | Sculptor Capital LP | 30,600 | 105,000 | 0.42% | Put | |
| 27 | Sculptor Capital LP | 30,600 | 105,000 | 0.42% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 28,420 | 98,000 | 0.39% | ||
| 29 | NORTHERN TRUST CORP | 26,389 | 90,000 | 0.36% | ||
| 30 | Jefferies Group LLC | 25,000 | 86,000 | 0.34% | ||
| 31 | JACOBS LEVY EQUITY MANAGEMENT, INC | 24,100 | 83,000 | 0.33% | ||
| 32 | WOLVERINE ASSET MANAGEMENT LLC | 22,800 | 78,000 | 0.31% | Put | |
| 33 | Bank of New York Mellon Corp | 18,996 | 66,000 | 0.26% | ||
| 34 | CITADEL ADVISORS LLC | 18,000 | 62,000 | 0.25% | Put | |
| 35 | CITIGROUP INC | 16,900 | 58,000 | 0.23% | Put | |
| 36 | CITADEL ADVISORS LLC | 15,800 | 54,000 | 0.21% | Call | |
| 37 | BANK OF AMERICA CORP /DE/ | 12,015 | 41,000 | 0.16% | ||
| 38 | CUTLER GROUP LLC / CA | 22,500 | 29,000 | 0.12% | Call | |
| 39 | SIMPLEX TRADING, LLC | 6,940 | 23,000 | 0.09% | ||
| 40 | UBS Group AG | 5,083 | 17,000 | 0.07% | ||
| 41 | ROYAL BANK OF CANADA | 2,830 | 10,000 | 0.04% | ||
| 42 | WOLVERINE ASSET MANAGEMENT LLC | 2,800 | 9,000 | 0.04% | ||
| 43 | CITIGROUP INC | 1,700 | 6,000 | 0.02% | ||
| 44 | FIRST MANHATTAN CO. LLC. | 2,000 | 6,000 | 0.02% | ||
| 45 | ADVISOR GROUP, INC. | 1,432 | 5,000 | 0.02% | ||
| 46 | CUTLER GROUP LLC / CA | 2,700 | 3,000 | 0.01% | Put | |
| 47 | ADVOCACY WEALTH MANAGEMENT SERVICES, LLC | 1,000 | 3,000 | 0.01% | ||
| 48 | CUTLER GROUP LLC / CA | 1,082 | 3,000 | 0.01% | ||
| 49 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 510 | 2,000 | 0.01% | ||
| 50 | Allworth Financial LP | 500 | 2,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
