| 1 |
BAUPOST GROUP LLC/MA |
2,226,839 |
3,875,000 |
37.08% |
|
|
| 2 |
BVF INC/IL |
734,976 |
1,279,000 |
12.24% |
|
|
| 3 |
Foresite Capital Management II, LLC |
542,755 |
944,000 |
9.03% |
|
|
| 4 |
NEA Management Company, LLC |
370,900 |
645,000 |
6.17% |
|
|
| 5 |
VANGUARD GROUP INC |
298,857 |
520,000 |
4.98% |
|
|
| 6 |
CREDIT SUISSE AG/ |
258,352 |
449,000 |
4.30% |
|
|
| 7 |
FORESITE CAPITAL MANAGEMENT III, LLC |
254,257 |
442,000 |
4.23% |
|
|
| 8 |
BlackRock Institutional Trust Company, N.A. |
213,649 |
372,000 |
3.56% |
|
|
| 9 |
Old West Investment Management, LLC |
206,018 |
358,000 |
3.43% |
|
|
| 10 |
Rock Springs Capital Management LP |
165,300 |
288,000 |
2.76% |
|
|
| 11 |
Rhenman & Partners Asset Management AB |
120,000 |
209,000 |
2.00% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
65,862 |
114,000 |
1.09% |
|
|
| 13 |
WOLVERINE ASSET MANAGEMENT LLC |
64,900 |
112,000 |
1.07% |
Put |
|
| 14 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
56,000 |
97,000 |
0.93% |
Put |
|
| 15 |
GOLDMAN SACHS GROUP INC |
52,385 |
91,000 |
0.87% |
|
|
| 16 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
47,815 |
83,000 |
0.79% |
|
|
| 17 |
MORGAN STANLEY |
36,408 |
63,000 |
0.60% |
|
|
| 18 |
Virtu KCG Holdings LLC |
33,815 |
59,000 |
0.56% |
|
|
| 19 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
29,720 |
52,000 |
0.50% |
|
|
| 20 |
GLG LLC |
27,800 |
48,000 |
0.46% |
|
|
| 21 |
NORTHERN TRUST CORP |
26,537 |
46,000 |
0.44% |
|
|
| 22 |
WELLS FARGO & COMPANY/MN |
23,550 |
41,000 |
0.39% |
|
|
| 23 |
TWO SIGMA SECURITIES, LLC |
22,934 |
40,000 |
0.38% |
|
|
| 24 |
MILLENNIUM MANAGEMENT LLC |
15,823 |
28,000 |
0.27% |
|
|
| 25 |
Squarepoint Ops LLC |
15,400 |
27,000 |
0.26% |
|
|
| 26 |
Bank of New York Mellon Corp |
14,994 |
26,000 |
0.25% |
|
|
| 27 |
BANK OF AMERICA CORP /DE/ |
13,297 |
23,000 |
0.22% |
|
|
| 28 |
Telemetry Investments, L.L.C. |
10,250 |
18,000 |
0.17% |
|
|
| 29 |
GROUP ONE TRADING LLC |
9,572 |
17,000 |
0.16% |
|
|
| 30 |
Tower Research Capital LLC (TRC) |
9,173 |
16,000 |
0.15% |
|
|
| 31 |
CITIGROUP INC |
8,220 |
14,000 |
0.13% |
Call |
|
| 32 |
CITIGROUP INC |
5,320 |
9,000 |
0.09% |
Put |
|
| 33 |
UBS Group AG |
3,710 |
6,000 |
0.06% |
|
|
| 34 |
BARCLAYS PLC |
3,784 |
6,000 |
0.06% |
|
|
| 35 |
BlackRock Fund Advisors |
2,812 |
5,000 |
0.05% |
|
|
| 36 |
ADVISOR GROUP, INC. |
2,632 |
5,000 |
0.05% |
|
|
| 37 |
BLACKROCK ADVISORS LLC |
1,808 |
3,000 |
0.03% |
|
|
| 38 |
BARCLAYS PLC |
1,450 |
3,000 |
0.03% |
Put |
|
| 39 |
FIRST MANHATTAN CO. LLC. |
2,000 |
3,000 |
0.03% |
|
|
| 40 |
DEUTSCHE BANK AG\ |
1,889 |
3,000 |
0.03% |
|
|
| 41 |
ADVOCACY WEALTH MANAGEMENT SERVICES, LLC |
1,000 |
2,000 |
0.02% |
|
|
| 42 |
Compagnie Lombard Odier SCmA |
1,000 |
2,000 |
0.02% |
|
|
| 43 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
700 |
1,000 |
0.01% |
|
|
| 44 |
BARCLAYS PLC |
860 |
1,000 |
0.01% |
Call |
|
| 45 |
CITIGROUP INC |
300 |
1,000 |
0.01% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
386 |
1,000 |
0.01% |
|
|
| 47 |
ROYAL BANK OF CANADA |
543 |
1,000 |
0.01% |
|
|
| 48 |
CUTLER GROUP LLC / CA |
878 |
1,000 |
0.01% |
|
|
| 49 |
Allworth Financial LP |
500 |
1,000 |
0.01% |
|
|
| 50 |
JPMORGAN CHASE & CO |
500 |
1,000 |
0.01% |
|
|
