| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAUPOST GROUP LLC/MA | 2,226,839 | 6,458,000 | 34.58% | ||
| 2 | BVF INC/IL | 734,976 | 2,131,000 | 11.41% | ||
| 3 | Foresite Capital Management II, LLC | 602,013 | 1,746,000 | 9.35% | ||
| 4 | FORESITE CAPITAL MANAGEMENT III, LLC | 380,530 | 1,104,000 | 5.91% | ||
| 5 | NEA Management Company, LLC | 370,900 | 1,076,000 | 5.76% | ||
| 6 | VANGUARD GROUP INC | 260,814 | 756,000 | 4.05% | ||
| 7 | CREDIT SUISSE AG/ | 234,543 | 680,000 | 3.64% | ||
| 8 | BlackRock Finance, Inc. | 224,904 | 653,000 | 3.50% | ||
| 9 | Old West Investment Management, LLC | 181,874 | 527,000 | 2.82% | ||
| 10 | Rock Springs Capital Management LP | 165,300 | 479,000 | 2.57% | ||
| 11 | Rhenman & Partners Asset Management AB | 120,000 | 348,000 | 1.86% | ||
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 81,200 | 235,000 | 1.26% | Put | |
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 73,400 | 213,000 | 1.14% | Call | |
| 14 | Telemetry Investments, L.L.C. | 70,253 | 204,000 | 1.09% | ||
| 15 | BANK OF MONTREAL /CAN/ | 68,500 | 199,000 | 1.07% | ||
| 16 | BANK OF MONTREAL /CAN/ | 68,500 | 199,000 | 1.07% | Put | |
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 64,228 | 186,000 | 1.00% | ||
| 18 | CITIGROUP INC | 50,580 | 147,000 | 0.79% | Call | |
| 19 | WELLS FARGO & COMPANY/MN | 45,638 | 132,000 | 0.71% | ||
| 20 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 45,320 | 132,000 | 0.71% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 36,086 | 105,000 | 0.56% | ||
| 22 | CITADEL ADVISORS LLC | 30,000 | 87,000 | 0.47% | Put | |
| 23 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 28,420 | 82,000 | 0.44% | ||
| 24 | Sculptor Capital LP | 27,200 | 79,000 | 0.42% | Put | |
| 25 | Sculptor Capital LP | 27,200 | 79,000 | 0.42% | ||
| 26 | NORTHERN TRUST CORP | 26,267 | 76,000 | 0.41% | ||
| 27 | MORGAN STANLEY | 25,113 | 72,000 | 0.39% | ||
| 28 | CITADEL ADVISORS LLC | 20,920 | 61,000 | 0.33% | ||
| 29 | SABBY MANAGEMENT, LLC | 19,700 | 57,000 | 0.31% | ||
| 30 | GOLDMAN SACHS GROUP INC | 17,411 | 50,000 | 0.27% | ||
| 31 | WOLVERINE ASSET MANAGEMENT LLC | 15,900 | 46,000 | 0.25% | Put | |
| 32 | Bank of New York Mellon Corp | 14,721 | 43,000 | 0.23% | ||
| 33 | BANK OF AMERICA CORP /DE/ | 14,550 | 42,000 | 0.22% | ||
| 34 | Virtu KCG Holdings LLC | 14,238 | 41,000 | 0.22% | ||
| 35 | CITIGROUP INC | 12,860 | 37,000 | 0.20% | ||
| 36 | SIMPLEX TRADING, LLC | 9,292 | 26,000 | 0.14% | ||
| 37 | CITIGROUP INC | 7,800 | 23,000 | 0.12% | Put | |
| 38 | UBS Group AG | 5,129 | 15,000 | 0.08% | ||
| 39 | CUTLER GROUP LLC / CA | 3,637 | 10,000 | 0.05% | ||
| 40 | WOLVERINE ASSET MANAGEMENT LLC | 2,800 | 8,000 | 0.04% | ||
| 41 | ROYAL BANK OF CANADA | 2,326 | 7,000 | 0.04% | ||
| 42 | PRELUDE CAPITAL MANAGEMENT, LLC | 2,200 | 6,000 | 0.03% | ||
| 43 | FIRST MANHATTAN CO. LLC. | 2,000 | 5,000 | 0.03% | ||
| 44 | ADVISOR GROUP, INC. | 1,432 | 4,000 | 0.02% | ||
| 45 | ADVOCACY WEALTH MANAGEMENT SERVICES, LLC | 1,000 | 3,000 | 0.02% | ||
| 46 | JPMORGAN CHASE & CO | 500 | 1,000 | 0.01% | ||
| 47 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 369 | 1,000 | 0.01% | ||
| 48 | CUTLER GROUP LLC / CA | 1,400 | 1,000 | 0.01% | Put | |
| 49 | Allworth Financial LP | 500 | 1,000 | 0.01% | ||
| 50 | Creative Planning | 2,200 | 0 | 0.00% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
