| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,774,845 | 15,515,000 | 24.76% | ||
| 2 | Numeric Investors LLC | 1,225,545 | 5,037,000 | 8.04% | ||
| 3 | BlackRock Fund Advisors | 1,194,090 | 4,908,000 | 7.83% | ||
| 4 | VHCP Management, LLC | 1,102,735 | 4,532,000 | 7.23% | ||
| 5 | RENAISSANCE TECHNOLOGIES LLC | 1,004,400 | 4,128,000 | 6.59% | ||
| 6 | EcoR1 Capital, LLC | 946,263 | 3,889,000 | 6.21% | ||
| 7 | VANGUARD GROUP INC | 658,188 | 2,705,000 | 4.32% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 457,325 | 1,880,000 | 3.00% | ||
| 9 | PRIMECAP MANAGEMENT CO/CA/ | 426,300 | 1,752,000 | 2.80% | ||
| 10 | SABBY MANAGEMENT, LLC | 402,603 | 1,655,000 | 2.64% | ||
| 11 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 340,297 | 1,399,000 | 2.23% | ||
| 12 | STATE STREET CORP | 297,156 | 1,220,000 | 1.95% | ||
| 13 | VHCP MANAGEMENT II, LLC | 280,000 | 1,151,000 | 1.84% | ||
| 14 | Connor, Clark & Lunn Investment Management Ltd. | 262,250 | 1,078,000 | 1.72% | ||
| 15 | DEUTSCHE BANK AG\ | 259,539 | 1,065,000 | 1.70% | ||
| 16 | NORTHERN TRUST CORP | 221,258 | 910,000 | 1.45% | ||
| 17 | PANAGORA ASSET MANAGEMENT INC | 199,069 | 818,000 | 1.31% | ||
| 18 | JW Asset Management, LLC | 189,919 | 781,000 | 1.25% | ||
| 19 | NORGES BANK | 167,273 | 657,000 | 1.05% | ||
| 20 | Rhenman & Partners Asset Management AB | 154,006 | 632,965 | 1.01% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 124,556 | 511,000 | 0.82% | ||
| 22 | SCHRODER INVESTMENT MANAGEMENT GROUP | 110,939 | 456,000 | 0.73% | ||
| 23 | BlackRock Investment Management, LLC | 109,597 | 450,000 | 0.72% | ||
| 24 | EMERALD ACQUISITION LTD. | 108,326 | 446,000 | 0.71% | ||
| 25 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 98,382 | 404,000 | 0.64% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 93,219 | 383,000 | 0.61% | ||
| 27 | ROYCE & ASSOCIATES LP | 92,346 | 380,000 | 0.61% | ||
| 28 | TFS CAPITAL LLC | 77,645 | 319,000 | 0.51% | ||
| 29 | Bank of New York Mellon Corp | 67,346 | 277,000 | 0.44% | ||
| 30 | KNOTT DAVID M | 66,000 | 271,000 | 0.43% | ||
| 31 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 52,000 | 214,000 | 0.34% | ||
| 32 | GILDER GAGNON HOWE & CO LLC | 50,876 | 209,000 | 0.33% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,737 | 200,000 | 0.32% | ||
| 34 | JPMORGAN CHASE & CO | 47,709 | 196,000 | 0.31% | ||
| 35 | PDT Partners, LLC | 40,246 | 165,000 | 0.26% | ||
| 36 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 34,479 | 142,000 | 0.23% | ||
| 37 | GOLDMAN SACHS GROUP INC | 32,773 | 135,000 | 0.22% | ||
| 38 | TEACHERS ADVISORS, LLC | 30,703 | 126,000 | 0.20% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 28,209 | 116,000 | 0.19% | ||
| 40 | ProShare Advisors LLC | 28,344 | 116,000 | 0.19% | ||
| 41 | RHUMBLINE ADVISERS | 24,772 | 102,000 | 0.16% | ||
| 42 | ALLIANCEBERNSTEIN L.P. | 24,300 | 100,000 | 0.16% | ||
| 43 | DIMENSIONAL FUND ADVISORS LP | 22,325 | 92,000 | 0.15% | ||
| 44 | Redmile Group, LLC | 22,236 | 91,000 | 0.15% | ||
| 45 | TWO SIGMA SECURITIES, LLC | 21,239 | 87,000 | 0.14% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 17,900 | 74,000 | 0.12% | ||
| 47 | Nationwide Fund Advisors | 16,437 | 68,000 | 0.11% | ||
| 48 | Integre Asset Management, LLC | 15,475 | 64,000 | 0.10% | ||
| 49 | CREDIT SUISSE AG/ | 14,647 | 60,000 | 0.10% | ||
| 50 | WELLS FARGO & COMPANY/MN | 14,447 | 59,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
