| 1 |
FMR LLC |
3,865,153 |
12,214,000 |
24.51% |
|
|
| 2 |
Numeric Investors LLC |
1,134,931 |
3,586,000 |
7.20% |
|
|
| 3 |
BlackRock Fund Advisors |
1,107,900 |
3,501,000 |
7.03% |
|
|
| 4 |
VHCP Management, LLC |
1,102,735 |
3,485,000 |
6.99% |
|
|
| 5 |
SABBY MANAGEMENT, LLC |
779,926 |
2,465,000 |
4.95% |
|
|
| 6 |
RENAISSANCE TECHNOLOGIES LLC |
735,137 |
2,323,000 |
4.66% |
|
|
| 7 |
VANGUARD GROUP INC |
689,788 |
2,180,000 |
4.38% |
|
|
| 8 |
GREAT POINT PARTNERS LLC |
550,116 |
1,738,000 |
3.49% |
|
|
| 9 |
BlackRock Institutional Trust Company, N.A. |
433,201 |
1,369,000 |
2.75% |
|
|
| 10 |
PRIMECAP MANAGEMENT CO/CA/ |
423,900 |
1,340,000 |
2.69% |
|
|
| 11 |
NORTHERN TRUST CORP |
370,745 |
1,172,000 |
2.35% |
|
|
| 12 |
Connor, Clark & Lunn Investment Management Ltd. |
302,450 |
956,000 |
1.92% |
|
|
| 13 |
STATE STREET CORP |
294,140 |
929,000 |
1.86% |
|
|
| 14 |
VHCP MANAGEMENT II, LLC |
280,000 |
885,000 |
1.78% |
|
|
| 15 |
DEUTSCHE BANK AG\ |
255,214 |
806,000 |
1.62% |
|
|
| 16 |
PANAGORA ASSET MANAGEMENT INC |
210,163 |
664,000 |
1.33% |
|
|
| 17 |
ROYCE & ASSOCIATES LP |
193,346 |
611,000 |
1.23% |
|
|
| 18 |
JW Asset Management, LLC |
189,919 |
600,000 |
1.20% |
|
|
| 19 |
Granite Point Capital Management, L.P. |
186,544 |
589,000 |
1.18% |
|
|
| 20 |
NORGES BANK |
167,273 |
529,000 |
1.06% |
|
|
| 21 |
TFS CAPITAL LLC |
159,364 |
504,000 |
1.01% |
|
|
| 22 |
Rhenman & Partners Asset Management AB |
154,006 |
487,000 |
0.98% |
|
|
| 23 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
146,520 |
463,000 |
0.93% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
141,984 |
449,000 |
0.90% |
|
|
| 25 |
DAFNA Capital Management LLC |
140,600 |
444,000 |
0.89% |
|
|
| 26 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
139,039 |
439,000 |
0.88% |
|
|
| 27 |
AQR CAPITAL MANAGEMENT LLC |
123,953 |
392,000 |
0.79% |
|
|
| 28 |
GEODE CAPITAL MANAGEMENT, LLC |
122,365 |
386,000 |
0.77% |
|
|
| 29 |
SCHRODER INVESTMENT MANAGEMENT GROUP |
110,939 |
351,000 |
0.70% |
|
|
| 30 |
MILLENNIUM MANAGEMENT LLC |
98,100 |
310,000 |
0.62% |
|
|
| 31 |
BlackRock Investment Management, LLC |
91,859 |
290,000 |
0.58% |
|
|
| 32 |
D. E. Shaw & Co., Inc. |
91,205 |
288,000 |
0.58% |
|
|
| 33 |
GOLDMAN SACHS GROUP INC |
67,624 |
214,000 |
0.43% |
|
|
| 34 |
Bank of New York Mellon Corp |
60,721 |
192,000 |
0.39% |
|
|
| 35 |
OXFORD ASSET MANAGEMENT LLP |
60,477 |
191,000 |
0.38% |
|
|
| 36 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
52,000 |
164,000 |
0.33% |
|
|
| 37 |
GILDER GAGNON HOWE & CO LLC |
50,888 |
161,000 |
0.32% |
|
|
| 38 |
CREDIT SUISSE AG/ |
49,696 |
157,000 |
0.32% |
|
|
| 39 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
48,237 |
152,000 |
0.31% |
|
|
| 40 |
PDT Partners, LLC |
46,646 |
147,000 |
0.30% |
|
|
| 41 |
TWO SIGMA ADVISERS, LP |
44,200 |
140,000 |
0.28% |
|
|
| 42 |
TEACHERS ADVISORS, LLC |
36,789 |
116,000 |
0.23% |
|
|
| 43 |
ProShare Advisors LLC |
33,496 |
106,000 |
0.21% |
|
|
| 44 |
JPMORGAN CHASE & CO |
32,250 |
102,000 |
0.20% |
|
|
| 45 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
29,521 |
93,000 |
0.19% |
|
|
| 46 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
28,948 |
91,000 |
0.18% |
|
|
| 47 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
28,209 |
90,000 |
0.18% |
|
|
| 48 |
ALLIANCEBERNSTEIN L.P. |
26,200 |
83,000 |
0.17% |
|
|
| 49 |
RHUMBLINE ADVISERS |
24,272 |
77,000 |
0.15% |
|
|
| 50 |
Redmile Group, LLC |
22,236 |
70,000 |
0.14% |
|
|
