| 1 |
FMR LLC |
3,706,402 |
10,749,000 |
24.57% |
|
|
| 2 |
Numeric Investors LLC |
1,235,345 |
3,583,000 |
8.19% |
|
|
| 3 |
VHCP Management, LLC |
1,102,735 |
3,198,000 |
7.31% |
|
|
| 4 |
RENAISSANCE TECHNOLOGIES LLC |
969,700 |
2,812,000 |
6.43% |
|
|
| 5 |
EcoR1 Capital, LLC |
874,447 |
2,536,000 |
5.80% |
|
|
| 6 |
BlackRock Fund Advisors |
758,714 |
2,200,000 |
5.03% |
|
|
| 7 |
VANGUARD GROUP INC |
485,779 |
1,409,000 |
3.22% |
|
|
| 8 |
BlackRock Institutional Trust Company, N.A. |
478,837 |
1,389,000 |
3.18% |
|
|
| 9 |
PRIMECAP MANAGEMENT CO/CA/ |
425,600 |
1,234,000 |
2.82% |
|
|
| 10 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
363,400 |
1,054,000 |
2.41% |
|
|
| 11 |
MILLENNIUM MANAGEMENT LLC |
339,471 |
984,000 |
2.25% |
|
|
| 12 |
STATE STREET CORP |
321,273 |
934,000 |
2.14% |
|
|
| 13 |
SABBY MANAGEMENT, LLC |
283,306 |
822,000 |
1.88% |
|
|
| 14 |
VHCP MANAGEMENT II, LLC |
280,000 |
812,000 |
1.86% |
|
|
| 15 |
683 Capital Management, LLC |
250,000 |
725,000 |
1.66% |
|
|
| 16 |
Connor, Clark & Lunn Investment Management Ltd. |
230,350 |
668,000 |
1.53% |
|
|
| 17 |
NORTHERN TRUST CORP |
222,695 |
646,000 |
1.48% |
|
|
| 18 |
PANAGORA ASSET MANAGEMENT INC |
183,673 |
533,000 |
1.22% |
|
|
| 19 |
JW Asset Management, LLC |
178,654 |
519,000 |
1.19% |
|
|
| 20 |
NORGES BANK |
167,273 |
485,000 |
1.11% |
|
|
| 21 |
Rhenman & Partners Asset Management AB |
154,006 |
447,000 |
1.02% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
131,182 |
380,000 |
0.87% |
|
|
| 23 |
Granite Point Capital Management, L.P. |
130,001 |
377,000 |
0.86% |
|
|
| 24 |
Anson Funds Management LP |
128,539 |
373,000 |
0.85% |
|
|
| 25 |
SCHRODER INVESTMENT MANAGEMENT GROUP |
110,939 |
322,000 |
0.74% |
|
|
| 26 |
BlackRock Investment Management, LLC |
109,597 |
318,000 |
0.73% |
|
|
| 27 |
JPMORGAN CHASE & CO |
109,563 |
317,000 |
0.72% |
|
|
| 28 |
DEUTSCHE BANK AG\ |
106,523 |
307,000 |
0.70% |
|
|
| 29 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
75,667 |
219,000 |
0.50% |
|
|
| 30 |
Bank of New York Mellon Corp |
72,564 |
211,000 |
0.48% |
|
|
| 31 |
MORGAN STANLEY |
68,875 |
200,000 |
0.46% |
|
|
| 32 |
KNOTT DAVID M |
66,000 |
191,000 |
0.44% |
|
|
| 33 |
WELLS FARGO & COMPANY/MN |
56,151 |
163,000 |
0.37% |
|
|
| 34 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
54,881 |
159,000 |
0.36% |
|
|
| 35 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
52,000 |
151,000 |
0.35% |
|
|
| 36 |
TEZA CAPITAL MANAGEMENT LLC |
51,060 |
148,000 |
0.34% |
|
|
| 37 |
GILDER GAGNON HOWE & CO LLC |
50,876 |
148,000 |
0.34% |
|
|
| 38 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
48,037 |
139,000 |
0.32% |
|
|
| 39 |
TEACHERS ADVISORS, LLC |
39,037 |
113,000 |
0.26% |
|
|
| 40 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
37,555 |
108,000 |
0.25% |
|
|
| 41 |
GOLDMAN SACHS GROUP INC |
37,254 |
108,000 |
0.25% |
|
|
| 42 |
PDT Partners, LLC |
34,546 |
100,000 |
0.23% |
|
|
| 43 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
33,170 |
96,000 |
0.22% |
|
|
| 44 |
DIMENSIONAL FUND ADVISORS LP |
32,429 |
94,000 |
0.21% |
|
|
| 45 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
29,320 |
85,000 |
0.19% |
|
|
| 46 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
28,209 |
82,000 |
0.19% |
|
|
| 47 |
TURNER INVESTMENTS LLC |
25,000 |
73,000 |
0.17% |
|
|
| 48 |
CITIGROUP INC |
25,150 |
73,000 |
0.17% |
|
|
| 49 |
ALLIANCEBERNSTEIN L.P. |
24,300 |
70,000 |
0.16% |
|
|
| 50 |
Redmile Group, LLC |
22,236 |
64,000 |
0.15% |
|
|
