| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 3,556,778 | 55,450,000 | 22.19% | ||
| 2 | Cormorant Asset Management, LP | 2,350,000 | 36,636,000 | 14.66% | ||
| 3 | FMR LLC | 2,314,468 | 36,083,000 | 14.44% | ||
| 4 | JENNISON ASSOCIATES LLC | 1,229,362 | 19,166,000 | 7.67% | ||
| 5 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 763,790 | 11,907,000 | 4.76% | ||
| 6 | FIL Ltd | 652,316 | 10,170,000 | 4.07% | ||
| 7 | FRANKLIN RESOURCES INC | 625,000 | 9,744,000 | 3.90% | ||
| 8 | EcoR1 Capital, LLC | 602,315 | 9,390,000 | 3.76% | ||
| 9 | Rock Springs Capital Management LP | 450,000 | 7,016,000 | 2.81% | ||
| 10 | VANGUARD GROUP INC | 371,864 | 5,797,000 | 2.32% | ||
| 11 | PERCEPTIVE ADVISORS LLC | 344,550 | 5,372,000 | 2.15% | ||
| 12 | MARSHALL WACE, LLP | 334,970 | 5,222,000 | 2.09% | ||
| 13 | EVENTIDE ASSET MANAGEMENT, LLC | 220,000 | 3,430,000 | 1.37% | ||
| 14 | BlackRock Fund Advisors | 215,224 | 3,355,000 | 1.34% | ||
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 214,717 | 3,347,000 | 1.34% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 192,900 | 3,007,000 | 1.20% | ||
| 17 | DEERFIELD MANAGEMENT COMPANY, L.P. | 186,000 | 2,900,000 | 1.16% | ||
| 18 | Avoro Capital Advisors LLC | 179,565 | 2,799,000 | 1.12% | ||
| 19 | JPMORGAN CHASE & CO | 172,650 | 2,692,000 | 1.08% | ||
| 20 | Opaleye Management Inc. | 152,000 | 2,370,000 | 0.95% | ||
| 21 | STATE STREET CORP | 95,617 | 1,490,000 | 0.60% | ||
| 22 | MONASHEE INVESTMENT MANAGEMENT LLC | 85,000 | 1,325,000 | 0.53% | PRN | |
| 23 | Informed Momentum Co LLC | 82,553 | 1,287,000 | 0.51% | ||
| 24 | NORTHERN TRUST CORP | 81,660 | 1,273,000 | 0.51% | ||
| 25 | BALYASNY ASSET MANAGEMENT L.P. | 75,000 | 1,169,000 | 0.47% | ||
| 26 | Alyeska Investment Group, L.P. | 75,000 | 1,169,000 | 0.47% | ||
| 27 | BlackRock Institutional Trust Company, N.A. | 52,807 | 823,000 | 0.33% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 51,358 | 800,000 | 0.32% | ||
| 29 | BlackRock Investment Management, LLC | 32,586 | 508,000 | 0.20% | ||
| 30 | TWO SIGMA INVESTMENTS, LP | 32,411 | 505,000 | 0.20% | ||
| 31 | CITADEL ADVISORS LLC | 25,345 | 395,000 | 0.16% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 22,144 | 345,000 | 0.14% | ||
| 33 | Bank of New York Mellon Corp | 21,227 | 331,000 | 0.13% | ||
| 34 | MORGAN STANLEY | 20,476 | 319,000 | 0.13% | ||
| 35 | WESTFIELD CAPITAL MANAGEMENT CO LP | 19,695 | 307,000 | 0.12% | ||
| 36 | VICTORY CAPITAL MANAGEMENT INC | 19,690 | 307,000 | 0.12% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 16,883 | 263,000 | 0.11% | ||
| 38 | TFS CAPITAL LLC | 14,941 | 233,000 | 0.09% | ||
| 39 | TEACHERS ADVISORS, LLC | 10,394 | 162,000 | 0.06% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,000 | 156,000 | 0.06% | ||
| 41 | NEW YORK STATE COMMON RETIREMENT FUND | 8,100 | 126,000 | 0.05% | ||
| 42 | SG Americas Securities, LLC | 6,723 | 105,000 | 0.04% | ||
| 43 | ClariVest Asset Management LLC | 6,218 | 97,000 | 0.04% | ||
| 44 | DEUTSCHE BANK AG\ | 5,142 | 79,000 | 0.03% | ||
| 45 | STRS OHIO | 5,000 | 77,000 | 0.03% | ||
| 46 | Nationwide Fund Advisors | 4,618 | 72,000 | 0.03% | ||
| 47 | Tower Research Capital LLC (TRC) | 4,055 | 63,000 | 0.03% | ||
| 48 | AMERICAN INTERNATIONAL GROUP, INC. | 3,651 | 56,919 | 0.02% | ||
| 49 | BLACKROCK ADVISORS LLC | 2,894 | 45,000 | 0.02% | ||
| 50 | UBS Group AG | 2,396 | 37,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
