| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 9,458,567 | 80,492,000 | 33.57% | ||
| 2 | Aisling Capital LLC | 7,480,887 | 63,662,000 | 26.55% | ||
| 3 | FMR LLC | 6,742,183 | 57,376,000 | 23.93% | ||
| 4 | FIL Ltd | 745,916 | 6,348,000 | 2.65% | ||
| 5 | VANGUARD GROUP INC | 615,014 | 5,234,000 | 2.18% | ||
| 6 | ACUTA CAPITAL PARTNERS, LLC | 601,073 | 4,637,000 | 1.93% | ||
| 7 | RTW INVESTMENTS, LP | 515,612 | 4,388,000 | 1.83% | ||
| 8 | NEXT CENTURY GROWTH INVESTORS LLC | 351,018 | 2,987,000 | 1.25% | ||
| 9 | BlackRock Finance, Inc. | 297,773 | 2,534,000 | 1.06% | ||
| 10 | Informed Momentum Co LLC | 189,470 | 1,612,000 | 0.67% | ||
| 11 | GEODE CAPITAL MANAGEMENT, LLC | 149,463 | 1,271,000 | 0.53% | ||
| 12 | RAYMOND JAMES & ASSOCIATES | 123,000 | 1,047,000 | 0.44% | ||
| 13 | NORTHERN TRUST CORP | 94,849 | 808,000 | 0.34% | ||
| 14 | AMERIPRISE FINANCIAL INC | 78,549 | 669,000 | 0.28% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 66,241 | 564,000 | 0.24% | ||
| 16 | GOLDMAN SACHS GROUP INC | 56,910 | 484,000 | 0.20% | ||
| 17 | CARL DOMINO INC | 55,000 | 468,000 | 0.20% | ||
| 18 | STATE STREET CORP | 54,042 | 460,000 | 0.19% | ||
| 19 | MORGAN STANLEY | 48,476 | 412,000 | 0.17% | ||
| 20 | Bank of New York Mellon Corp | 44,372 | 377,000 | 0.16% | ||
| 21 | Trexquant Investment LP | 41,904 | 357,000 | 0.15% | ||
| 22 | Virtu KCG Holdings LLC | 36,667 | 312,000 | 0.13% | ||
| 23 | INTRINSIC EDGE CAPITAL MANAGEMENT LLC | 35,800 | 305,000 | 0.13% | ||
| 24 | ROYAL BANK OF CANADA | 31,785 | 271,000 | 0.11% | ||
| 25 | CITADEL ADVISORS LLC | 31,520 | 268,000 | 0.11% | ||
| 26 | TFS CAPITAL LLC | 29,484 | 251,000 | 0.10% | ||
| 27 | Sequoia Financial Advisors, LLC | 25,000 | 213,000 | 0.09% | ||
| 28 | JANE STREET GROUP, LLC | 24,169 | 206,000 | 0.09% | ||
| 29 | UBS Group AG | 22,479 | 192,000 | 0.08% | ||
| 30 | WELLS FARGO & COMPANY/MN | 20,865 | 177,000 | 0.07% | ||
| 31 | BOSTON FINANCIAL MANGEMENT LLC | 20,000 | 170,000 | 0.07% | ||
| 32 | HighTower Advisors, LLC | 20,000 | 170,000 | 0.07% | ||
| 33 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 19,679 | 167,000 | 0.07% | ||
| 34 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 13,700 | 117,000 | 0.05% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,619 | 116,000 | 0.05% | ||
| 36 | Squarepoint Ops LLC | 12,642 | 108,000 | 0.05% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 11,242 | 96,000 | 0.04% | ||
| 38 | DEUTSCHE BANK AG\ | 9,196 | 77,000 | 0.03% | ||
| 39 | TEACHERS ADVISORS, LLC | 6,996 | 60,000 | 0.03% | ||
| 40 | BARCLAYS PLC | 5,660 | 48,000 | 0.02% | ||
| 41 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 5,275 | 46,000 | 0.02% | ||
| 42 | Tower Research Capital LLC (TRC) | 5,373 | 46,000 | 0.02% | ||
| 43 | JPMORGAN CHASE & CO | 4,807 | 41,000 | 0.02% | ||
| 44 | AMERICAN INTERNATIONAL GROUP, INC. | 4,082 | 35,000 | 0.01% | ||
| 45 | Vantage Investment Advisors, LLC | 3,000 | 26,000 | 0.01% | ||
| 46 | CLOSE ASSET MANAGEMENT LTD | 2,000 | 17,000 | 0.01% | ||
| 47 | NEW YORK STATE COMMON RETIREMENT FUND | 1,933 | 16,000 | 0.01% | ||
| 48 | Nationwide Fund Advisors | 1,754 | 15,000 | 0.01% | ||
| 49 | BANK OF AMERICA CORP /DE/ | 1,546 | 13,000 | 0.01% | ||
| 50 | PNC FINANCIAL SERVICES GROUP, INC. | 1,000 | 9,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
