| 1 |
FMR LLC |
3,758,921 |
25,786,000 |
22.33% |
|
|
| 2 |
Omega Fund Management, LLC |
2,814,928 |
19,310,000 |
16.72% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
2,304,600 |
15,810,000 |
13.69% |
|
|
| 4 |
FEDERATED HERMES, INC. |
2,053,453 |
14,087,000 |
12.20% |
|
|
| 5 |
Broadfin Capital, LLC |
1,134,750 |
7,784,000 |
6.74% |
|
|
| 6 |
WASATCH ADVISORS LP |
726,436 |
4,983,000 |
4.32% |
|
|
| 7 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
597,123 |
4,096,000 |
3.55% |
|
|
| 8 |
VANGUARD GROUP INC |
411,551 |
2,823,000 |
2.44% |
|
|
| 9 |
BlackRock Fund Advisors |
353,437 |
2,425,000 |
2.10% |
|
|
| 10 |
Rock Springs Capital Management LP |
300,000 |
2,058,000 |
1.78% |
|
|
| 11 |
SPHERA FUNDS MANAGEMENT LTD. |
292,500 |
2,007,000 |
1.74% |
|
|
| 12 |
Avoro Capital Advisors LLC |
233,334 |
1,601,000 |
1.39% |
|
|
| 13 |
WALL STREET ASSOCIATES |
228,890 |
1,570,000 |
1.36% |
|
|
| 14 |
EMERALD ADVISERS, LLC |
227,279 |
1,559,000 |
1.35% |
|
|
| 15 |
HighTower Advisors, LLC |
211,048 |
1,448,000 |
1.25% |
|
|
| 16 |
TIVERTON ASSET MANAGEMENT LLC |
209,136 |
1,435,000 |
1.24% |
|
|
| 17 |
Brandywine Global Investment Management, LLC |
163,678 |
1,123,000 |
0.97% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
100,129 |
687,000 |
0.59% |
|
|
| 19 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
99,700 |
684,000 |
0.59% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
59,330 |
407,000 |
0.35% |
|
|
| 21 |
Janney Montgomery Scott LLC |
54,278 |
372,000 |
0.32% |
|
|
| 22 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
48,767 |
335,000 |
0.29% |
|
|
| 23 |
HAP Trading, LLC |
42,000 |
288,000 |
0.25% |
|
|
| 24 |
GOLDMAN SACHS GROUP INC |
40,328 |
277,000 |
0.24% |
|
|
| 25 |
UBS Group AG |
33,067 |
227,000 |
0.20% |
|
|
| 26 |
MILLENNIUM MANAGEMENT LLC |
29,291 |
201,000 |
0.17% |
|
|
| 27 |
KEYBANK NATIONAL ASSOCIATION/OH |
29,291 |
201,000 |
0.17% |
|
|
| 28 |
CREDIT SUISSE AG/ |
28,764 |
197,000 |
0.17% |
|
|
| 29 |
NOMURA HOLDINGS INC |
28,794 |
197,000 |
0.17% |
|
|
| 30 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
28,500 |
196,000 |
0.17% |
|
|
| 31 |
NORTHERN TRUST CORP |
28,133 |
193,000 |
0.17% |
|
|
| 32 |
JPMORGAN CHASE & CO |
26,238 |
180,000 |
0.16% |
|
|
| 33 |
Segantii Capital Management Ltd |
18,986 |
130,000 |
0.11% |
|
|
| 34 |
ProShare Advisors LLC |
18,409 |
126,000 |
0.11% |
|
|
| 35 |
DEUTSCHE BANK AG\ |
16,187 |
110,000 |
0.10% |
|
|
| 36 |
D. E. Shaw & Co., Inc. |
13,970 |
96,000 |
0.08% |
|
|
| 37 |
Bank of New York Mellon Corp |
12,422 |
85,000 |
0.07% |
|
|
| 38 |
DekaBank Deutsche Girozentrale |
12,000 |
82,000 |
0.07% |
|
|
| 39 |
JFS WEALTH ADVISORS, LLC |
4,553 |
73,000 |
0.06% |
|
|
| 40 |
WELLS FARGO & COMPANY/MN |
10,102 |
69,000 |
0.06% |
|
|
| 41 |
MORGAN STANLEY |
9,973 |
68,000 |
0.06% |
|
|
| 42 |
CITIGROUP INC |
3,182 |
22,000 |
0.02% |
|
|
| 43 |
SONORA INVESTMENT MANAGEMENT, LLC |
3,000 |
21,120 |
0.02% |
|
|
| 44 |
BlackRock Investment Management, LLC |
2,193 |
15,000 |
0.01% |
|
|
| 45 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
2,150 |
15,000 |
0.01% |
|
|
| 46 |
ROYAL BANK OF CANADA |
1,388 |
10,000 |
0.01% |
|
|
| 47 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
847 |
6,000 |
0.01% |
|
|
| 48 |
BLACKROCK ADVISORS LLC |
613 |
4,000 |
0.00% |
|
|
| 49 |
BARCLAYS PLC |
261 |
1,000 |
0.00% |
|
|
| 50 |
Tower Research Capital LLC (TRC) |
3 |
0 |
0.00% |
|
|
