| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,758,921 | 41,423,000 | 22.77% | ||
| 2 | Omega Fund Management, LLC | 2,814,928 | 31,021,000 | 17.05% | ||
| 3 | FRANKLIN RESOURCES INC | 2,304,600 | 25,397,000 | 13.96% | ||
| 4 | FEDERATED HERMES, INC. | 2,053,453 | 22,629,000 | 12.44% | ||
| 5 | Broadfin Capital, LLC | 1,134,750 | 12,505,000 | 6.87% | ||
| 6 | WASATCH ADVISORS LP | 559,567 | 6,166,000 | 3.39% | ||
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | 477,123 | 5,258,000 | 2.89% | ||
| 8 | Avoro Capital Advisors LLC | 432,606 | 4,767,000 | 2.62% | ||
| 9 | VANGUARD GROUP INC | 362,824 | 3,998,000 | 2.20% | ||
| 10 | BlackRock Fund Advisors | 324,478 | 3,576,000 | 1.97% | ||
| 11 | Rock Springs Capital Management LP | 300,000 | 3,306,000 | 1.82% | ||
| 12 | SPHERA FUNDS MANAGEMENT LTD. | 292,500 | 3,223,000 | 1.77% | ||
| 13 | TIVERTON ASSET MANAGEMENT LLC | 255,000 | 2,810,000 | 1.54% | ||
| 14 | WALL STREET ASSOCIATES | 228,890 | 2,522,000 | 1.39% | ||
| 15 | HighTower Advisors, LLC | 197,420 | 2,175,000 | 1.20% | ||
| 16 | Brandywine Global Investment Management, LLC | 190,666 | 2,102,000 | 1.16% | ||
| 17 | EMERALD ADVISERS, LLC | 179,444 | 1,977,000 | 1.09% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 100,129 | 1,103,000 | 0.61% | ||
| 19 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 99,700 | 1,099,000 | 0.60% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 57,030 | 628,000 | 0.35% | ||
| 21 | Janney Montgomery Scott LLC | 55,754 | 614,000 | 0.34% | ||
| 22 | RENAISSANCE TECHNOLOGIES LLC | 47,300 | 521,000 | 0.29% | ||
| 23 | HAP Trading, LLC | 42,000 | 463,000 | 0.25% | ||
| 24 | KEYBANK NATIONAL ASSOCIATION/OH | 29,291 | 323,000 | 0.18% | ||
| 25 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 28,500 | 314,000 | 0.17% | ||
| 26 | NORTHERN TRUST CORP | 28,133 | 310,000 | 0.17% | ||
| 27 | D. E. Shaw & Co., Inc. | 26,274 | 290,000 | 0.16% | ||
| 28 | ProShare Advisors LLC | 20,152 | 222,000 | 0.12% | ||
| 29 | GOLDMAN SACHS GROUP INC | 19,777 | 218,000 | 0.12% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 17,520 | 193,000 | 0.11% | ||
| 31 | CREDIT SUISSE AG/ | 16,398 | 180,000 | 0.10% | ||
| 32 | Bank of New York Mellon Corp | 12,352 | 136,000 | 0.07% | ||
| 33 | Bluefin Trading, LLC | 10,414 | 115,000 | 0.06% | ||
| 34 | WELLS FARGO & COMPANY/MN | 9,128 | 100,000 | 0.05% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 4,180 | 46,000 | 0.03% | ||
| 36 | DEUTSCHE BANK AG\ | 3,896 | 42,000 | 0.02% | ||
| 37 | CITIGROUP INC | 3,426 | 38,000 | 0.02% | ||
| 38 | MORGAN STANLEY | 3,248 | 36,000 | 0.02% | ||
| 39 | SONORA INVESTMENT MANAGEMENT, LLC | 3,000 | 33,000 | 0.02% | ||
| 40 | BlackRock Investment Management, LLC | 2,279 | 25,000 | 0.01% | ||
| 41 | ROYAL BANK OF CANADA | 1,388 | 15,000 | 0.01% | ||
| 42 | UBS Group AG | 897 | 10,000 | 0.01% | ||
| 43 | BLACKROCK ADVISORS LLC | 613 | 7,000 | 0.00% | ||
| 44 | BARCLAYS PLC | 484 | 5,000 | 0.00% | ||
| 45 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 125 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
