| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,254,407 | 112,182,000 | 37.21% | ||
| 2 | ORBIMED ADVISORS LLC | 2,662,180 | 56,838,000 | 18.85% | ||
| 3 | BAKER BROS. ADVISORS LP | 1,062,120 | 22,676,000 | 7.52% | ||
| 4 | Temasek Holdings (Private) Ltd | 790,527 | 16,878,000 | 5.60% | ||
| 5 | FORESITE CAPITAL MANAGEMENT III, LLC | 763,688 | 16,305,000 | 5.41% | ||
| 6 | BLACKROCK ADVISORS LLC | 615,749 | 13,146,000 | 4.36% | ||
| 7 | VANGUARD GROUP INC | 416,564 | 8,894,000 | 2.95% | ||
| 8 | EcoR1 Capital, LLC | 310,695 | 6,633,000 | 2.20% | ||
| 9 | MORGAN STANLEY | 301,358 | 6,434,000 | 2.13% | ||
| 10 | FRANKLIN RESOURCES INC | 300,000 | 6,405,000 | 2.12% | ||
| 11 | Artal Group S.A. | 225,000 | 4,804,000 | 1.59% | ||
| 12 | BlackRock Fund Advisors | 163,768 | 3,496,000 | 1.16% | ||
| 13 | GOLDMAN SACHS GROUP INC | 144,002 | 3,074,000 | 1.02% | ||
| 14 | Tekla Capital Management LLC | 86,842 | 1,854,000 | 0.61% | ||
| 15 | Invesco Ltd. | 82,994 | 1,771,000 | 0.59% | ||
| 16 | Neuberger Berman Group LLC | 77,486 | 1,654,000 | 0.55% | ||
| 17 | NORTHERN TRUST CORP | 75,683 | 1,615,000 | 0.54% | ||
| 18 | STATE STREET CORP | 70,874 | 1,513,000 | 0.50% | ||
| 19 | SECTORAL ASSET MANAGEMENT INC | 123,159 | 1,466,000 | 0.49% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 67,346 | 1,437,000 | 0.48% | ||
| 21 | EMERALD ACQUISITION LTD. | 60,954 | 1,302,000 | 0.43% | ||
| 22 | JPMORGAN CHASE & CO | 60,925 | 1,301,000 | 0.43% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 57,913 | 1,236,000 | 0.41% | ||
| 24 | GLG LLC | 34,176 | 730,000 | 0.24% | ||
| 25 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 27,268 | 582,000 | 0.19% | ||
| 26 | BlackRock Investment Management, LLC | 25,900 | 553,000 | 0.18% | ||
| 27 | Wildcat Capital Management, LLC | 25,000 | 534,000 | 0.18% | ||
| 28 | Spark Investment Management LLC | 23,290 | 497,000 | 0.16% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,754 | 486,000 | 0.16% | ||
| 30 | Bank of New York Mellon Corp | 21,626 | 462,000 | 0.15% | ||
| 31 | ALLIANCEBERNSTEIN L.P. | 20,300 | 433,000 | 0.14% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 20,125 | 430,000 | 0.14% | ||
| 33 | MONASHEE INVESTMENT MANAGEMENT LLC | 19,898 | 425,000 | 0.14% | PRN | |
| 34 | SOCIETE GENERALE | 17,509 | 374,000 | 0.12% | ||
| 35 | SG Americas Securities, LLC | 17,509 | 374,000 | 0.12% | ||
| 36 | PERCEPTIVE ADVISORS LLC | 15,000 | 320,000 | 0.11% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,643 | 313,000 | 0.10% | ||
| 38 | MARSHALL WACE, LLP | 11,408 | 244,000 | 0.08% | ||
| 39 | TEACHERS ADVISORS, LLC | 10,990 | 235,000 | 0.08% | ||
| 40 | SCHONFELD STRATEGIC ADVISORS LLC | 10,443 | 223,000 | 0.07% | ||
| 41 | METROPOLITAN LIFE INSURANCE CO/NY | 8,886 | 190,000 | 0.06% | ||
| 42 | DEUTSCHE BANK AG\ | 7,932 | 168,000 | 0.06% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 7,200 | 154,000 | 0.05% | ||
| 44 | NumerixS Investment Technologies Inc | 5,500 | 117,000 | 0.04% | ||
| 45 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 4,783 | 102,000 | 0.03% | ||
| 46 | GLG Partners LP | 4,697 | 100,000 | 0.03% | ||
| 47 | Nationwide Fund Advisors | 4,539 | 97,000 | 0.03% | ||
| 48 | AMERICAN INTERNATIONAL GROUP, INC. | 4,020 | 85,827 | 0.03% | ||
| 49 | Compagnie Lombard Odier SCmA | 3,000 | 64,000 | 0.02% | ||
| 50 | BlackRock Finance, Inc. | 2,464 | 53,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
