| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,765,481 | 62,475,000 | 25.92% | ||
| 2 | ATLAS VENTURE ASSOCIATES IX, LLC | 4,429,788 | 58,075,000 | 24.09% | ||
| 3 | ORBIMED ADVISORS LLC | 2,662,180 | 34,901,000 | 14.48% | ||
| 4 | BAKER BROS. ADVISORS LP | 1,062,120 | 13,924,000 | 5.78% | ||
| 5 | VANGUARD GROUP INC | 870,783 | 11,416,000 | 4.74% | ||
| 6 | Temasek Holdings (Private) Ltd | 790,527 | 10,364,000 | 4.30% | ||
| 7 | BlackRock Fund Advisors | 704,350 | 9,234,000 | 3.83% | ||
| 8 | FORESITE CAPITAL MANAGEMENT III, LLC | 703,563 | 9,224,000 | 3.83% | ||
| 9 | FRANKLIN RESOURCES INC | 300,000 | 3,933,000 | 1.63% | ||
| 10 | Artal Group S.A. | 250,000 | 3,278,000 | 1.36% | ||
| 11 | MORGAN STANLEY | 245,480 | 3,218,000 | 1.34% | ||
| 12 | GOLDMAN SACHS GROUP INC | 162,703 | 2,133,000 | 0.88% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 158,551 | 2,079,000 | 0.86% | ||
| 14 | Alyeska Investment Group, L.P. | 140,000 | 1,835,000 | 0.76% | ||
| 15 | SABBY MANAGEMENT, LLC | 130,000 | 1,704,000 | 0.71% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 128,308 | 1,682,000 | 0.70% | ||
| 17 | STATE STREET CORP | 92,355 | 1,211,000 | 0.50% | ||
| 18 | NORTHERN TRUST CORP | 77,959 | 1,022,000 | 0.42% | ||
| 19 | Tekla Capital Management LLC | 71,842 | 942,000 | 0.39% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 71,804 | 941,000 | 0.39% | ||
| 21 | NORGES BANK | 67,571 | 886,000 | 0.37% | ||
| 22 | Neuberger Berman Group LLC | 45,736 | 600,000 | 0.25% | ||
| 23 | SG Americas Securities, LLC | 36,794 | 482,000 | 0.20% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 36,415 | 477,000 | 0.20% | ||
| 25 | Bank of New York Mellon Corp | 29,994 | 394,000 | 0.16% | ||
| 26 | ARK INVESTMENT MANAGEMENT LLC | 26,544 | 348,000 | 0.14% | ||
| 27 | BlackRock Investment Management, LLC | 25,834 | 339,000 | 0.14% | ||
| 28 | ALLIANCEBERNSTEIN L.P. | 25,800 | 338,000 | 0.14% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 25,420 | 333,000 | 0.14% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 25,364 | 333,000 | 0.14% | ||
| 31 | ProShare Advisors LLC | 24,902 | 326,000 | 0.14% | ||
| 32 | Swiss National Bank | 20,700 | 271,000 | 0.11% | ||
| 33 | Virtu KCG Holdings LLC | 20,545 | 269,000 | 0.11% | ||
| 34 | PERCEPTIVE ADVISORS LLC | 14,673 | 192,000 | 0.08% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,343 | 188,000 | 0.08% | ||
| 36 | CREDIT SUISSE AG/ | 12,379 | 162,000 | 0.07% | ||
| 37 | UBS Group AG | 11,455 | 150,000 | 0.06% | ||
| 38 | BARCLAYS PLC | 11,213 | 148,000 | 0.06% | ||
| 39 | TEACHERS ADVISORS, LLC | 10,990 | 144,000 | 0.06% | ||
| 40 | Commonwealth Equity Services, Inc | 10,800 | 142,000 | 0.06% | ||
| 41 | ClariVest Asset Management LLC | 9,077 | 119,000 | 0.05% | ||
| 42 | ROYAL BANK OF CANADA | 8,915 | 117,000 | 0.05% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 7,200 | 94,000 | 0.04% | ||
| 44 | Nationwide Fund Advisors | 4,539 | 60,000 | 0.02% | ||
| 45 | DEUTSCHE BANK AG\ | 4,438 | 57,000 | 0.02% | ||
| 46 | AMERICAN INTERNATIONAL GROUP, INC. | 4,014 | 53,000 | 0.02% | ||
| 47 | Wildcat Capital Management, LLC | 3,542 | 46,000 | 0.02% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 3,282 | 43,000 | 0.02% | ||
| 49 | WELLS FARGO & COMPANY/MN | 3,300 | 42,000 | 0.02% | ||
| 50 | STRS OHIO | 3,200 | 41,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
