| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,000,935 | 56,373,000 | 31.58% | ||
| 2 | ORBIMED ADVISORS LLC | 2,662,180 | 37,510,000 | 21.01% | ||
| 3 | BAKER BROS. ADVISORS LP | 1,062,120 | 14,965,000 | 8.38% | ||
| 4 | BlackRock Finance, Inc. | 943,344 | 13,293,000 | 7.45% | ||
| 5 | VANGUARD GROUP INC | 904,708 | 12,747,000 | 7.14% | ||
| 6 | Temasek Holdings (Private) Ltd | 790,527 | 11,139,000 | 6.24% | ||
| 7 | GMT CAPITAL CORP | 330,533 | 4,657,000 | 2.61% | ||
| 8 | FRANKLIN RESOURCES INC | 300,000 | 4,227,000 | 2.37% | ||
| 9 | Artal Group S.A. | 250,000 | 3,523,000 | 1.97% | ||
| 10 | MORGAN STANLEY | 211,525 | 2,980,000 | 1.67% | ||
| 11 | SABBY MANAGEMENT, LLC | 140,000 | 1,973,000 | 1.11% | ||
| 12 | STATE STREET CORP | 108,435 | 1,527,000 | 0.86% | ||
| 13 | ACADIAN ASSET MANAGEMENT LLC | 96,153 | 1,355,000 | 0.76% | ||
| 14 | PAULSON & CO. INC. | 78,600 | 1,107,000 | 0.62% | ||
| 15 | NORTHERN TRUST CORP | 76,295 | 1,075,000 | 0.60% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 76,095 | 1,072,000 | 0.60% | ||
| 17 | Tekla Capital Management LLC | 71,842 | 1,012,000 | 0.57% | ||
| 18 | Alberta Investment Management Corp | 50,200 | 707,000 | 0.40% | ||
| 19 | Neuberger Berman Group LLC | 43,086 | 607,000 | 0.34% | ||
| 20 | CLOUGH CAPITAL PARTNERS L P | 42,600 | 600,000 | 0.34% | ||
| 21 | GOLDMAN SACHS GROUP INC | 40,700 | 573,000 | 0.32% | ||
| 22 | Bank of New York Mellon Corp | 31,676 | 446,000 | 0.25% | ||
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 26,903 | 380,000 | 0.21% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 25,881 | 365,000 | 0.20% | ||
| 25 | ALLIANCEBERNSTEIN L.P. | 25,800 | 364,000 | 0.20% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25,400 | 358,000 | 0.20% | Put | |
| 27 | ProShare Advisors LLC | 20,016 | 282,000 | 0.16% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 19,595 | 276,000 | 0.15% | ||
| 29 | BARCLAYS PLC | 18,872 | 267,000 | 0.15% | ||
| 30 | ZACKS INVESTMENT MANAGEMENT | 18,002 | 254,000 | 0.14% | ||
| 31 | BANK OF AMERICA CORP /DE/ | 17,840 | 251,000 | 0.14% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,043 | 198,000 | 0.11% | ||
| 33 | M&T BANK CORP | 11,516 | 162,000 | 0.09% | ||
| 34 | TEACHERS ADVISORS, LLC | 11,079 | 156,000 | 0.09% | ||
| 35 | WELLS FARGO & COMPANY/MN | 10,945 | 154,000 | 0.09% | ||
| 36 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 10,552 | 149,000 | 0.08% | ||
| 37 | A.R.T. Advisors, LLC | 10,541 | 148,000 | 0.08% | ||
| 38 | Commonwealth Equity Services, Inc | 10,450 | 147,000 | 0.08% | ||
| 39 | Magnetar Financial LLC | 10,081 | 142,000 | 0.08% | ||
| 40 | MERIDIAN INVESTMENT COUNSEL INC. | 10,000 | 141,000 | 0.08% | ||
| 41 | GROUP ONE TRADING LLC | 8,700 | 123,000 | 0.07% | ||
| 42 | NEW YORK STATE COMMON RETIREMENT FUND | 7,201 | 101,000 | 0.06% | ||
| 43 | ClariVest Asset Management LLC | 6,412 | 90,000 | 0.05% | ||
| 44 | SIMPLEX TRADING, LLC | 5,920 | 83,000 | 0.05% | ||
| 45 | AMERICAN INTERNATIONAL GROUP, INC. | 4,295 | 61,000 | 0.03% | ||
| 46 | ROYAL BANK OF CANADA | 4,302 | 61,000 | 0.03% | ||
| 47 | PRIVATE CAPITAL MANAGEMENT INC | 4,000 | 56,000 | 0.03% | ||
| 48 | Nationwide Fund Advisors | 3,697 | 52,000 | 0.03% | ||
| 49 | JPMORGAN CHASE & CO | 3,302 | 47,000 | 0.03% | ||
| 50 | Creative Planning | 3,000 | 42,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
