| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 1,410,417 | 23,624,000 | 29.93% | ||
| 2 | BAKER BROS. ADVISORS LP | 1,160,014 | 19,430,000 | 24.61% | ||
| 3 | FRANKLIN RESOURCES INC | 641,392 | 10,743,000 | 13.61% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 399,900 | 6,698,000 | 8.49% | ||
| 5 | Rock Springs Capital Management LP | 383,000 | 6,415,000 | 8.13% | ||
| 6 | Tekla Capital Management LLC | 260,000 | 4,355,000 | 5.52% | ||
| 7 | Iguana Healthcare Management, LLC | 200,000 | 3,350,000 | 4.24% | ||
| 8 | PLATINUM INVESTMENT MANAGEMENT LTD | 111,519 | 1,867,000 | 2.37% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 86,700 | 1,452,000 | 1.84% | ||
| 10 | NORGES BANK | 77,400 | 919,000 | 1.16% | ||
| 11 | JPMORGAN CHASE & CO | 2,971 | 50,000 | 0.06% | ||
| 12 | CITIGROUP INC | 2,000 | 34,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
