| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 1,410,417 | 11,269,000 | 29.22% | ||
| 2 | BAKER BROS. ADVISORS LP | 1,122,859 | 8,972,000 | 23.26% | ||
| 3 | FRANKLIN RESOURCES INC | 639,025 | 5,192,000 | 13.46% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 400,000 | 3,196,000 | 8.29% | ||
| 5 | Rock Springs Capital Management LP | 360,811 | 2,883,000 | 7.48% | ||
| 6 | Tekla Capital Management LLC | 260,000 | 2,113,000 | 5.48% | ||
| 7 | RA CAPITAL MANAGEMENT, L.P. | 237,599 | 1,898,000 | 4.92% | ||
| 8 | Iguana Healthcare Management, LLC | 200,000 | 1,598,000 | 4.14% | ||
| 9 | PLATINUM INVESTMENT MANAGEMENT LTD | 70,000 | 559,000 | 1.45% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 62,598 | 500,000 | 1.30% | ||
| 11 | NORGES BANK | 40,000 | 321,000 | 0.83% | ||
| 12 | CREDIT AGRICOLE S A | 3,647 | 29,000 | 0.08% | ||
| 13 | CITIGROUP INC | 2,000 | 16,000 | 0.04% | ||
| 14 | UBS Group AG | 1,406 | 11,000 | 0.03% | ||
| 15 | MORGAN STANLEY | 740 | 6,000 | 0.02% | ||
| 16 | Tower Research Capital LLC (TRC) | 679 | 5,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
