| 1 |
Novo Holdings A/S |
1,410,417 |
34,400,000 |
22.25% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
1,223,976 |
29,841,000 |
19.30% |
|
|
| 3 |
BAKER BROS. ADVISORS LP |
1,160,014 |
28,293,000 |
18.30% |
|
|
| 4 |
FRANKLIN RESOURCES INC |
636,328 |
15,514,000 |
10.04% |
|
|
| 5 |
Tekla Capital Management LLC |
479,150 |
11,682,000 |
7.56% |
|
|
| 6 |
PRICE T ROWE ASSOCIATES INC /MD/ |
391,529 |
9,545,000 |
6.17% |
|
|
| 7 |
Rock Springs Capital Management LP |
384,548 |
9,379,000 |
6.07% |
|
|
| 8 |
Nationwide Fund Advisors |
222,225 |
5,418,000 |
3.50% |
|
|
| 9 |
Iguana Healthcare Management, LLC |
175,000 |
4,268,000 |
2.76% |
|
|
| 10 |
PLATINUM INVESTMENT MANAGEMENT LTD |
102,219 |
2,492,000 |
1.61% |
|
|
| 11 |
VICTORY CAPITAL MANAGEMENT INC |
40,030 |
976,000 |
0.63% |
|
|
| 12 |
MILLENNIUM MANAGEMENT LLC |
28,486 |
695,000 |
0.45% |
|
|
| 13 |
RENAISSANCE TECHNOLOGIES LLC |
22,500 |
549,000 |
0.36% |
|
|
| 14 |
NORGES BANK |
20,000 |
488,000 |
0.32% |
|
|
| 15 |
Spark Investment Management LLC |
18,800 |
458,000 |
0.30% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
10,035 |
244,000 |
0.16% |
|
|
| 17 |
DEUTSCHE BANK AG\ |
9,279 |
226,000 |
0.15% |
|
|
| 18 |
ClariVest Asset Management LLC |
3,266 |
80,000 |
0.05% |
|
|
| 19 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
1,124 |
27,000 |
0.02% |
|
|
| 20 |
WELLS FARGO & COMPANY/MN |
300 |
7,000 |
0.00% |
|
|
| 21 |
BlackRock Finance, Inc. |
200 |
5,000 |
0.00% |
|
|
| 22 |
Financial Architects, Inc |
100 |
2,000 |
0.00% |
|
|
| 23 |
UBS Group AG |
30 |
1,000 |
0.00% |
|
|
| 24 |
ROYAL BANK OF CANADA |
2 |
0 |
0.00% |
|
|
