| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAUPOST GROUP LLC/MA | 25,000,000 | 23,578,000 | 27.96% | ||
| 2 | BVF INC/IL | 18,799,368 | 17,730,000 | 21.02% | ||
| 3 | NEA Management Company, LLC | 10,750,000 | 10,105,000 | 11.98% | ||
| 4 | FRANKLIN RESOURCES INC | 6,899,600 | 6,507,000 | 7.72% | ||
| 5 | Avoro Capital Advisors LLC | 5,744,723 | 5,418,000 | 6.42% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 3,414,121 | 3,220,000 | 3.82% | ||
| 7 | VANGUARD GROUP INC | 3,331,350 | 3,142,000 | 3.73% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 1,826,069 | 1,722,000 | 2.04% | ||
| 9 | EverPoint Asset Management, LLC | 1,500,000 | 1,415,000 | 1.68% | ||
| 10 | BlackRock Fund Advisors | 1,472,143 | 1,388,000 | 1.65% | ||
| 11 | FT OPTIONS LLC | 1,117,661 | 1,054,000 | 1.25% | ||
| 12 | DEUTSCHE BANK AG\ | 983,430 | 925,000 | 1.10% | ||
| 13 | Anson Funds Management LP | 898,000 | 847,000 | 1.00% | ||
| 14 | SABBY MANAGEMENT, LLC | 864,402 | 815,000 | 0.97% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 637,422 | 601,000 | 0.71% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 532,514 | 502,000 | 0.60% | ||
| 17 | First Eagle Investment Management, LLC | 400,000 | 377,000 | 0.45% | ||
| 18 | CREDIT SUISSE AG/ | 366,734 | 345,000 | 0.41% | ||
| 19 | Paloma Partners Management Co | 357,347 | 337,000 | 0.40% | ||
| 20 | ClariVest Asset Management LLC | 311,965 | 294,000 | 0.35% | ||
| 21 | PERKINS CAPITAL MANAGEMENT INC | 307,400 | 290,000 | 0.34% | ||
| 22 | GOLDMAN SACHS GROUP INC | 304,371 | 287,000 | 0.34% | ||
| 23 | Laurion Capital Management LP | 273,100 | 258,000 | 0.31% | ||
| 24 | SHEPHERD KAPLAN KROCHUK, LLC | 261,843 | 247,000 | 0.29% | ||
| 25 | JACOBS LEVY EQUITY MANAGEMENT, INC | 261,130 | 246,000 | 0.29% | ||
| 26 | Telemetry Investments, L.L.C. | 250,000 | 236,000 | 0.28% | ||
| 27 | A.R.T. Advisors, LLC | 226,273 | 213,000 | 0.25% | ||
| 28 | BLACKROCK ADVISORS LLC | 207,524 | 196,000 | 0.23% | ||
| 29 | DAFNA Capital Management LLC | 175,000 | 165,000 | 0.20% | ||
| 30 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 167,000 | 158,000 | 0.19% | ||
| 31 | NORTHERN TRUST CORP | 131,711 | 125,000 | 0.15% | ||
| 32 | Alpine Global Management, LLC | 127,866 | 121,000 | 0.14% | ||
| 33 | Bank of New York Mellon Corp | 123,578 | 116,000 | 0.14% | ||
| 34 | COWEN INC. | 114,200 | 108,000 | 0.13% | ||
| 35 | Squarepoint Ops LLC | 111,200 | 105,000 | 0.12% | ||
| 36 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 95,900 | 90,000 | 0.11% | ||
| 37 | Connor, Clark & Lunn Investment Management Ltd. | 95,000 | 89,000 | 0.11% | ||
| 38 | D. E. Shaw & Co., Inc. | 88,721 | 83,000 | 0.10% | ||
| 39 | STIFEL FINANCIAL CORP | 83,765 | 79,000 | 0.09% | ||
| 40 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 80,689 | 76,000 | 0.09% | ||
| 41 | ProShare Advisors LLC | 70,692 | 67,000 | 0.08% | ||
| 42 | STATE STREET CORP | 67,140 | 63,000 | 0.07% | ||
| 43 | OXFORD ASSET MANAGEMENT LLP | 63,321 | 60,000 | 0.07% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 54,307 | 51,000 | 0.06% | ||
| 45 | TUDOR INVESTMENT CORP ET AL | 48,760 | 46,000 | 0.05% | ||
| 46 | Tower Research Capital LLC (TRC) | 47,533 | 45,000 | 0.05% | ||
| 47 | Virtu KCG Holdings LLC | 45,226 | 43,000 | 0.05% | ||
| 48 | MORGAN STANLEY | 44,645 | 42,000 | 0.05% | ||
| 49 | HIGHLAND PRIVATE WEALTH MANAGEMENT | 35,000 | 33,000 | 0.04% | ||
| 50 | D.A. DAVIDSON & CO. | 31,000 | 29,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
