| 1 |
Polaris Venture Management Co. V, L.L.C. |
1,924,151 |
27,554,000 |
22.30% |
|
|
| 2 |
ORBIMED ADVISORS LLC |
1,842,797 |
26,389,000 |
21.36% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,060,000 |
15,179,000 |
12.28% |
|
|
| 4 |
FLAGSHIP VENTURES MANAGEMENT, INC. |
826,862 |
11,841,000 |
9.58% |
|
|
| 5 |
SILVER ROCK FINANCIAL LP |
677,025 |
9,675,000 |
7.83% |
|
|
| 6 |
FMR LLC |
285,700 |
4,091,000 |
3.31% |
|
|
| 7 |
JPMORGAN CHASE & CO |
244,369 |
3,499,000 |
2.83% |
|
|
| 8 |
MILLENNIUM MANAGEMENT LLC |
237,047 |
3,395,000 |
2.75% |
|
|
| 9 |
SPHERA FUNDS MANAGEMENT LTD. |
228,534 |
3,273,000 |
2.65% |
|
|
| 10 |
BlackRock Finance, Inc. |
208,593 |
2,987,000 |
2.42% |
|
|
| 11 |
BAKER BROS. ADVISORS LP |
175,712 |
2,516,000 |
2.04% |
|
|
| 12 |
PRICE T ROWE ASSOCIATES INC /MD/ |
152,400 |
2,182,000 |
1.77% |
|
|
| 13 |
PERCEPTIVE ADVISORS LLC |
141,875 |
2,032,000 |
1.64% |
|
|
| 14 |
VANGUARD GROUP INC |
78,988 |
1,131,000 |
0.92% |
|
|
| 15 |
HAMILTON LANE ADVISORS LLC |
74,833 |
1,072,000 |
0.87% |
|
|
| 16 |
WASATCH ADVISORS LP |
74,702 |
1,070,000 |
0.87% |
|
|
| 17 |
UBS Group AG |
71,361 |
1,022,000 |
0.83% |
|
|
| 18 |
STATE STREET CORP |
69,765 |
997,000 |
0.81% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
49,480 |
708,000 |
0.57% |
|
|
| 20 |
NORTHERN TRUST CORP |
39,477 |
566,000 |
0.46% |
|
|
| 21 |
GOLDMAN SACHS GROUP INC |
31,588 |
452,000 |
0.37% |
|
|
| 22 |
Candriam S.C.A. |
31,000 |
444,000 |
0.36% |
|
|
| 23 |
Hikari Power Ltd |
24,369 |
349,000 |
0.28% |
|
|
| 24 |
Bank of New York Mellon Corp |
14,736 |
211,000 |
0.17% |
|
|
| 25 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
13,415 |
192,000 |
0.16% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
10,500 |
150,000 |
0.12% |
|
|
| 27 |
MORGAN STANLEY |
9,410 |
135,000 |
0.11% |
|
|
| 28 |
TEACHERS ADVISORS, LLC |
5,402 |
77,000 |
0.06% |
|
|
| 29 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
5,133 |
74,000 |
0.06% |
|
|
| 30 |
WELLS FARGO & COMPANY/MN |
5,187 |
74,000 |
0.06% |
|
|
| 31 |
NEW YORK STATE COMMON RETIREMENT FUND |
4,401 |
63,000 |
0.05% |
|
|
| 32 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,120 |
45,000 |
0.04% |
|
|
| 33 |
Nationwide Fund Advisors |
2,032 |
29,000 |
0.02% |
|
|
| 34 |
STRS OHIO |
1,600 |
22,000 |
0.02% |
|
|
| 35 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,214 |
17,000 |
0.01% |
|
|
| 36 |
DEUTSCHE BANK AG\ |
1,255 |
17,000 |
0.01% |
|
|
| 37 |
BANK OF AMERICA CORP /DE/ |
902 |
13,000 |
0.01% |
|
|
| 38 |
Legal & General Group Plc |
571 |
8,000 |
0.01% |
|
|
| 39 |
Ameritas Investment Partners, Inc. |
433 |
6,000 |
0.00% |
|
|
| 40 |
ROYAL BANK OF CANADA |
319 |
5,000 |
0.00% |
|
|
| 41 |
Crestwood Advisors Group, LLC |
338 |
4,000 |
0.00% |
|
|
| 42 |
CITIGROUP INC |
220 |
3,000 |
0.00% |
|
|
| 43 |
SeaBridge Investment Advisors LLC |
95 |
1,000 |
0.00% |
|
|
| 44 |
BNP PARIBAS FINANCIAL MARKETS |
55 |
788 |
0.00% |
|
|
| 45 |
MEEDER ASSET MANAGEMENT INC |
20 |
0 |
0.00% |
|
|
| 46 |
BARCLAYS PLC |
31 |
0 |
0.00% |
|
|
