| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Polaris Venture Management Co. V, L.L.C. | 1,924,151 | 27,419,000 | 25.85% | ||
| 2 | ORBIMED ADVISORS LLC | 1,842,797 | 26,260,000 | 24.76% | ||
| 3 | FLAGSHIP VENTURES MANAGEMENT, INC. | 1,651,862 | 23,539,000 | 22.20% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 348,150 | 4,961,000 | 4.68% | ||
| 5 | JPMORGAN CHASE & CO | 307,893 | 4,387,000 | 4.14% | ||
| 6 | FMR LLC | 285,700 | 4,071,000 | 3.84% | ||
| 7 | SPHERA FUNDS MANAGEMENT LTD. | 284,652 | 3,989,000 | 3.76% | ||
| 8 | BAKER BROS. ADVISORS LP | 178,950 | 2,550,000 | 2.40% | ||
| 9 | Alyeska Investment Group, L.P. | 161,473 | 2,301,000 | 2.17% | ||
| 10 | BlackRock Fund Advisors | 136,556 | 1,946,000 | 1.83% | ||
| 11 | VANGUARD GROUP INC | 117,618 | 1,676,000 | 1.58% | ||
| 12 | WASATCH ADVISORS LP | 74,772 | 1,066,000 | 1.01% | ||
| 13 | GOLDMAN SACHS GROUP INC | 54,279 | 773,000 | 0.73% | ||
| 14 | Laurion Capital Management LP | 25,000 | 356,000 | 0.34% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 11,168 | 159,000 | 0.15% | ||
| 16 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,800 | 154,000 | 0.15% | ||
| 17 | UBS Group AG | 10,516 | 149,000 | 0.14% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 7,073 | 101,000 | 0.10% | ||
| 19 | TEACHERS ADVISORS, LLC | 5,402 | 77,000 | 0.07% | ||
| 20 | BlackRock Investment Management, LLC | 2,728 | 39,000 | 0.04% | ||
| 21 | STRS OHIO | 1,600 | 22,000 | 0.02% | ||
| 22 | MORGAN STANLEY | 1,550 | 22,000 | 0.02% | ||
| 23 | BlackRock Japan Co. Ltd | 632 | 9,000 | 0.01% | ||
| 24 | BLACKROCK ADVISORS LLC | 485 | 7,000 | 0.01% | ||
| 25 | CITIGROUP INC | 417 | 6,000 | 0.01% | ||
| 26 | Tower Research Capital LLC (TRC) | 415 | 6,000 | 0.01% | ||
| 27 | BANK OF AMERICA CORP /DE/ | 177 | 3,000 | 0.00% | ||
| 28 | BNP PARIBAS FINANCIAL MARKETS | 183 | 2,608 | 0.00% | ||
| 29 | ROYAL BANK OF CANADA | 100 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
