| 1 |
Polaris Venture Management Co. V, L.L.C. |
1,924,151 |
32,999,000 |
23.53% |
|
|
| 2 |
ORBIMED ADVISORS LLC |
1,842,797 |
31,604,000 |
22.53% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
853,205 |
14,632,000 |
10.43% |
|
|
| 4 |
FLAGSHIP VENTURES MANAGEMENT, INC. |
826,862 |
14,181,000 |
10.11% |
|
|
| 5 |
SILVER ROCK FINANCIAL LP |
461,076 |
7,907,000 |
5.64% |
|
|
| 6 |
FMR LLC |
285,700 |
4,900,000 |
3.49% |
|
|
| 7 |
SPHERA FUNDS MANAGEMENT LTD. |
268,534 |
4,605,000 |
3.28% |
|
|
| 8 |
JPMORGAN CHASE & CO |
260,117 |
4,460,000 |
3.18% |
|
|
| 9 |
PRICE T ROWE ASSOCIATES INC /MD/ |
248,393 |
4,260,000 |
3.04% |
|
|
| 10 |
BAKER BROS. ADVISORS LP |
175,712 |
3,013,000 |
2.15% |
|
|
| 11 |
BlackRock Fund Advisors |
159,573 |
2,737,000 |
1.95% |
|
|
| 12 |
PERCEPTIVE ADVISORS LLC |
141,875 |
2,433,000 |
1.73% |
|
|
| 13 |
MILLENNIUM MANAGEMENT LLC |
121,998 |
2,092,000 |
1.49% |
|
|
| 14 |
STATE OF MICHIGAN RETIREMENT SYSTEM |
95,993 |
1,646,000 |
1.17% |
|
|
| 15 |
HAMILTON LANE ADVISORS LLC |
74,833 |
1,283,000 |
0.91% |
|
|
| 16 |
WASATCH ADVISORS LP |
74,772 |
1,282,000 |
0.91% |
|
|
| 17 |
STATE STREET CORP |
69,665 |
1,195,000 |
0.85% |
|
|
| 18 |
VANGUARD GROUP INC |
67,837 |
1,164,000 |
0.83% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
46,670 |
800,000 |
0.57% |
|
|
| 20 |
NORTHERN TRUST CORP |
36,962 |
634,000 |
0.45% |
|
|
| 21 |
BlackRock Institutional Trust Company, N.A. |
33,739 |
579,000 |
0.41% |
|
|
| 22 |
GOLDMAN SACHS GROUP INC |
17,256 |
296,000 |
0.21% |
|
|
| 23 |
HILLMAN CO |
16,932 |
290,000 |
0.21% |
|
|
| 24 |
MORGAN STANLEY |
14,946 |
256,000 |
0.18% |
|
|
| 25 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
10,500 |
180,000 |
0.13% |
|
|
| 26 |
Hillsdale Investment Management Inc. |
8,400 |
144,000 |
0.10% |
|
|
| 27 |
BlackRock Investment Management, LLC |
5,645 |
97,000 |
0.07% |
|
|
| 28 |
TEACHERS ADVISORS, LLC |
5,402 |
93,000 |
0.07% |
|
|
| 29 |
UBS Group AG |
5,423 |
93,000 |
0.07% |
|
|
| 30 |
WELLS FARGO & COMPANY/MN |
5,187 |
89,000 |
0.06% |
|
|
| 31 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
4,783 |
82,000 |
0.06% |
|
|
| 32 |
NEW YORK STATE COMMON RETIREMENT FUND |
4,400 |
75,000 |
0.05% |
|
|
| 33 |
DEUTSCHE BANK AG\ |
3,242 |
54,000 |
0.04% |
|
|
| 34 |
BLACKROCK ADVISORS LLC |
1,947 |
33,000 |
0.02% |
|
|
| 35 |
STRS OHIO |
1,600 |
27,000 |
0.02% |
|
|
| 36 |
BANK OF AMERICA CORP /DE/ |
702 |
12,000 |
0.01% |
|
|
| 37 |
Legal & General Group Plc |
571 |
10,000 |
0.01% |
|
|
| 38 |
Tower Research Capital LLC (TRC) |
543 |
9,000 |
0.01% |
|
|
| 39 |
BNP PARIBAS FINANCIAL MARKETS |
298 |
5,111 |
0.00% |
|
|
| 40 |
ROYAL BANK OF CANADA |
314 |
5,000 |
0.00% |
|
|
| 41 |
BlackRock Finance, Inc. |
173 |
3,000 |
0.00% |
|
|
| 42 |
SeaBridge Investment Advisors LLC |
95 |
2,000 |
0.00% |
|
|
| 43 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
72 |
1,000 |
0.00% |
|
|
| 44 |
CITIGROUP INC |
4 |
0 |
0.00% |
|
|
| 45 |
BARCLAYS PLC |
10 |
0 |
0.00% |
|
|
