| 1 |
Novo Holdings A/S |
3,367,763 |
66,513,000 |
63.14% |
|
|
| 2 |
FMR LLC |
550,000 |
10,863,000 |
10.31% |
|
|
| 3 |
JPMORGAN CHASE & CO |
242,978 |
4,799,000 |
4.56% |
|
|
| 4 |
EMERALD MUTUAL FUND ADVISERS TRUST |
182,390 |
3,602,000 |
3.42% |
|
|
| 5 |
EMERALD ADVISERS, LLC |
167,610 |
3,310,000 |
3.14% |
|
|
| 6 |
PARAGON ASSOCIATES & PARAGON ASSOCIATES II JOINT VENTURE |
150,000 |
2,963,000 |
2.81% |
|
|
| 7 |
BlackRock Fund Advisors |
147,097 |
2,905,000 |
2.76% |
|
|
| 8 |
STATE STREET CORP |
63,411 |
1,253,000 |
1.19% |
|
|
| 9 |
GOLDMAN SACHS GROUP INC |
55,104 |
1,088,000 |
1.03% |
|
|
| 10 |
BlackRock Institutional Trust Company, N.A. |
53,629 |
1,059,000 |
1.01% |
|
|
| 11 |
NORTHERN TRUST CORP |
51,640 |
1,019,000 |
0.97% |
|
|
| 12 |
BLUE CREEK INVESTMENT PARTNERS, LLC |
50,178 |
991,000 |
0.94% |
|
|
| 13 |
VANGUARD GROUP INC |
47,915 |
946,000 |
0.90% |
|
|
| 14 |
Spark Investment Management LLC |
34,300 |
677,000 |
0.64% |
|
|
| 15 |
BlackRock Investment Management, LLC |
21,926 |
433,000 |
0.41% |
|
|
| 16 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
18,855 |
372,000 |
0.35% |
|
|
| 17 |
BANK OF AMERICA CORP /DE/ |
16,537 |
327,000 |
0.31% |
|
|
| 18 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
11,925 |
236,000 |
0.22% |
|
|
| 19 |
DAVENPORT & Co LLC |
11,363 |
224,419 |
0.21% |
|
|
| 20 |
Bank of New York Mellon Corp |
10,971 |
217,000 |
0.21% |
|
|
| 21 |
PNC FINANCIAL SERVICES GROUP, INC. |
10,000 |
198,000 |
0.19% |
|
|
| 22 |
TEACHERS ADVISORS, LLC |
8,968 |
177,000 |
0.17% |
|
|
| 23 |
BLACKROCK ADVISORS LLC |
7,416 |
146,000 |
0.14% |
|
|
| 24 |
MORGAN STANLEY |
7,043 |
139,000 |
0.13% |
|
|
| 25 |
BARCLAYS PLC |
6,084 |
120,000 |
0.11% |
|
|
| 26 |
DEUTSCHE BANK AG\ |
5,992 |
118,000 |
0.11% |
|
|
| 27 |
BANK OF MONTREAL /CAN/ |
5,162 |
102,000 |
0.10% |
|
|
| 28 |
NEW YORK STATE COMMON RETIREMENT FUND |
5,026 |
99,000 |
0.09% |
|
|
| 29 |
Smithfield Trust Co |
4,746 |
94,000 |
0.09% |
|
|
| 30 |
BlackRock Finance, Inc. |
3,877 |
77,000 |
0.07% |
|
|
| 31 |
Nationwide Fund Advisors |
3,662 |
72,000 |
0.07% |
|
|
| 32 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,274 |
64,662 |
0.06% |
|
|
| 33 |
UBS Group AG |
2,000 |
40,000 |
0.04% |
|
|
| 34 |
STRS OHIO |
1,900 |
37,000 |
0.04% |
|
|
| 35 |
UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO |
1,159 |
23,000 |
0.02% |
|
|
| 36 |
CITIGROUP INC |
572 |
11,000 |
0.01% |
|
|
| 37 |
Tower Research Capital LLC (TRC) |
432 |
8,000 |
0.01% |
|
|
| 38 |
NumerixS Investment Technologies Inc |
300 |
6,000 |
0.01% |
|
|
| 39 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
300 |
6,000 |
0.01% |
|
|
| 40 |
BNP PARIBAS FINANCIAL MARKETS |
225 |
4,444 |
0.00% |
|
|
| 41 |
BlackRock Japan Co. Ltd |
65 |
1,000 |
0.00% |
|
|
