| 1 |
Novo Holdings A/S |
3,367,763 |
88,774,000 |
61.23% |
|
|
| 2 |
FMR LLC |
479,024 |
12,627,000 |
8.71% |
|
|
| 3 |
EMERALD ADVISERS, LLC |
240,878 |
6,350,000 |
4.38% |
|
|
| 4 |
EMERALD MUTUAL FUND ADVISERS TRUST |
229,440 |
6,048,000 |
4.17% |
|
|
| 5 |
BlackRock Fund Advisors |
153,342 |
4,042,000 |
2.79% |
|
|
| 6 |
PARAGON ASSOCIATES & PARAGON ASSOCIATES II JOINT VENTURE |
150,000 |
3,954,000 |
2.73% |
|
|
| 7 |
JPMORGAN CHASE & CO |
140,678 |
3,708,000 |
2.56% |
|
|
| 8 |
VANGUARD GROUP INC |
127,398 |
3,358,000 |
2.32% |
|
|
| 9 |
STATE STREET CORP |
95,535 |
2,517,000 |
1.74% |
|
|
| 10 |
BlackRock Institutional Trust Company, N.A. |
95,109 |
2,507,000 |
1.73% |
|
|
| 11 |
NORTHERN TRUST CORP |
61,879 |
1,632,000 |
1.13% |
|
|
| 12 |
BLUE CREEK INVESTMENT PARTNERS, LLC |
54,432 |
1,435,000 |
0.99% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
52,623 |
1,387,000 |
0.96% |
|
|
| 14 |
Osborn Williams & Donohoe LLC |
47,000 |
1,239,000 |
0.85% |
|
|
| 15 |
UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO |
28,593 |
754,000 |
0.52% |
|
|
| 16 |
BlackRock Investment Management, LLC |
21,867 |
576,000 |
0.40% |
|
|
| 17 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
18,855 |
497,000 |
0.34% |
|
|
| 18 |
MORGAN STANLEY |
15,610 |
411,000 |
0.28% |
|
|
| 19 |
Bank of New York Mellon Corp |
15,570 |
410,000 |
0.28% |
|
|
| 20 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,025 |
317,000 |
0.22% |
|
|
| 21 |
DAVENPORT & Co LLC |
11,363 |
299,528 |
0.21% |
|
|
| 22 |
ALLIANCEBERNSTEIN L.P. |
11,000 |
290,000 |
0.20% |
|
|
| 23 |
PNC FINANCIAL SERVICES GROUP, INC. |
10,000 |
264,000 |
0.18% |
|
|
| 24 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
9,100 |
240,000 |
0.17% |
|
|
| 25 |
TEACHERS ADVISORS, LLC |
8,968 |
236,000 |
0.16% |
|
|
| 26 |
GOLDMAN SACHS GROUP INC |
8,542 |
225,000 |
0.16% |
|
|
| 27 |
NEW YORK STATE COMMON RETIREMENT FUND |
7,026 |
185,000 |
0.13% |
|
|
| 28 |
STRS OHIO |
6,800 |
179,000 |
0.12% |
|
|
| 29 |
Smithfield Trust Co |
4,746 |
125,000 |
0.09% |
|
|
| 30 |
Nationwide Fund Advisors |
3,662 |
97,000 |
0.07% |
|
|
| 31 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,279 |
86,434 |
0.06% |
|
|
| 32 |
BLACKROCK ADVISORS LLC |
2,187 |
58,000 |
0.04% |
|
|
| 33 |
WELLS FARGO & COMPANY/MN |
2,157 |
57,000 |
0.04% |
|
|
| 34 |
DEUTSCHE BANK AG\ |
935 |
24,000 |
0.02% |
|
|
| 35 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
700 |
18,000 |
0.01% |
|
|
| 36 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
549 |
14,000 |
0.01% |
|
|
| 37 |
CITIGROUP INC |
466 |
12,000 |
0.01% |
|
|
| 38 |
BNP PARIBAS FINANCIAL MARKETS |
395 |
10,412 |
0.01% |
|
|
| 39 |
BlackRock Finance, Inc. |
218 |
6,000 |
0.00% |
|
|
| 40 |
BANK OF AMERICA CORP /DE/ |
237 |
6,000 |
0.00% |
|
|
| 41 |
Tower Research Capital LLC (TRC) |
100 |
3,000 |
0.00% |
|
|
| 42 |
BARCLAYS PLC |
37 |
1,000 |
0.00% |
|
|
