| 1 |
Novo Holdings A/S |
3,367,763 |
73,518,000 |
59.11% |
|
|
| 2 |
EMERALD ADVISERS, LLC |
327,147 |
7,142,000 |
5.74% |
|
|
| 3 |
PARAGON ASSOCIATES & PARAGON ASSOCIATES II JOINT VENTURE |
250,000 |
5,458,000 |
4.39% |
|
|
| 4 |
EMERALD MUTUAL FUND ADVISERS TRUST |
229,559 |
5,011,000 |
4.03% |
|
|
| 5 |
BlackRock Fund Advisors |
183,797 |
4,012,000 |
3.23% |
|
|
| 6 |
FMR LLC |
169,006 |
3,689,000 |
2.97% |
|
|
| 7 |
JPMORGAN CHASE & CO |
145,093 |
3,167,000 |
2.55% |
|
|
| 8 |
VANGUARD GROUP INC |
142,880 |
3,119,000 |
2.51% |
|
|
| 9 |
BlackRock Institutional Trust Company, N.A. |
129,657 |
2,830,000 |
2.28% |
|
|
| 10 |
STATE STREET CORP |
100,414 |
2,191,000 |
1.76% |
|
|
| 11 |
LBJ Family Wealth Advisors, Ltd. |
90,200 |
1,969,000 |
1.58% |
|
|
| 12 |
NORTHERN TRUST CORP |
63,106 |
1,377,000 |
1.11% |
|
|
| 13 |
BLUE CREEK INVESTMENT PARTNERS, LLC |
54,432 |
1,188,000 |
0.96% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
53,381 |
1,165,000 |
0.94% |
|
|
| 15 |
Osborn Williams & Donohoe LLC |
47,000 |
1,026,000 |
0.82% |
|
|
| 16 |
MILLENNIUM MANAGEMENT LLC |
43,554 |
951,000 |
0.76% |
|
|
| 17 |
MORGAN STANLEY |
26,058 |
568,000 |
0.46% |
|
|
| 18 |
UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO |
22,747 |
497,000 |
0.40% |
|
|
| 19 |
DAVENPORT & Co LLC |
22,588 |
493,000 |
0.40% |
|
|
| 20 |
BlackRock Investment Management, LLC |
22,050 |
481,000 |
0.39% |
|
|
| 21 |
Bank of New York Mellon Corp |
18,806 |
411,000 |
0.33% |
|
|
| 22 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
18,800 |
411,000 |
0.33% |
|
|
| 23 |
BESSEMER GROUP INC |
17,401 |
380,000 |
0.31% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
16,914 |
369,000 |
0.30% |
|
|
| 25 |
INTERWEST VENTURE MANAGEMENT CO |
13,058 |
285,000 |
0.23% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
11,725 |
256,000 |
0.21% |
|
|
| 27 |
VIRTUS ETF ADVISERS LLC |
11,672 |
255,000 |
0.21% |
|
|
| 28 |
ALLIANCEBERNSTEIN L.P. |
11,000 |
240,000 |
0.19% |
|
|
| 29 |
TEACHERS ADVISORS, LLC |
10,116 |
221,000 |
0.18% |
|
|
| 30 |
PNC FINANCIAL SERVICES GROUP, INC. |
10,000 |
218,000 |
0.18% |
|
|
| 31 |
Dynamic Technology Lab Private Ltd |
9,908 |
216,000 |
0.17% |
|
|
| 32 |
Smithfield Trust Co |
9,244 |
202,000 |
0.16% |
|
|
| 33 |
NEW YORK STATE COMMON RETIREMENT FUND |
7,026 |
153,000 |
0.12% |
|
|
| 34 |
STRS OHIO |
6,800 |
148,000 |
0.12% |
|
|
| 35 |
CITIGROUP INC |
5,721 |
125,000 |
0.10% |
|
|
| 36 |
WELLS FARGO & COMPANY/MN |
4,070 |
88,000 |
0.07% |
|
|
| 37 |
Nationwide Fund Advisors |
3,662 |
80,000 |
0.06% |
|
|
| 38 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,270 |
71,000 |
0.06% |
|
|
| 39 |
DEUTSCHE BANK AG\ |
3,235 |
70,000 |
0.06% |
|
|
| 40 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
3,137 |
68,000 |
0.05% |
|
|
| 41 |
UBS Group AG |
2,488 |
54,000 |
0.04% |
|
|
| 42 |
Walleye Trading LLC |
2,200 |
48,000 |
0.04% |
|
|
| 43 |
BLACKROCK ADVISORS LLC |
2,097 |
46,000 |
0.04% |
|
|
| 44 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,757 |
38,000 |
0.03% |
|
|
| 45 |
BARCLAYS PLC |
981 |
21,000 |
0.02% |
|
|
| 46 |
BANK OF AMERICA CORP /DE/ |
782 |
17,000 |
0.01% |
|
|
| 47 |
Legal & General Group Plc |
616 |
13,000 |
0.01% |
|
|
| 48 |
Tower Research Capital LLC (TRC) |
562 |
12,000 |
0.01% |
|
|
| 49 |
BNP PARIBAS FINANCIAL MARKETS |
275 |
6,003 |
0.00% |
|
|
| 50 |
BlackRock Finance, Inc. |
218 |
5,000 |
0.00% |
|
|
