| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FLAGSHIP VENTURES MANAGEMENT, INC. | 4,806,656 | 76,570,000 | 37.30% | ||
| 2 | FMR LLC | 3,508,937 | 55,897,000 | 27.23% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,615,136 | 25,729,000 | 12.53% | ||
| 4 | Redmile Group, LLC | 952,740 | 15,177,000 | 7.39% | ||
| 5 | Aisling Capital LLC | 508,565 | 8,101,000 | 3.95% | ||
| 6 | BAKER BROS. ADVISORS LP | 204,465 | 3,257,000 | 1.59% | ||
| 7 | CASDIN CAPITAL, LLC | 182,141 | 2,902,000 | 1.41% | ||
| 8 | BlackRock Finance, Inc. | 179,368 | 2,857,000 | 1.39% | ||
| 9 | EVENTIDE ASSET MANAGEMENT, LLC | 150,000 | 2,390,000 | 1.16% | ||
| 10 | VANGUARD GROUP INC | 132,096 | 2,104,000 | 1.02% | ||
| 11 | JPMORGAN CHASE & CO | 120,556 | 1,921,000 | 0.94% | ||
| 12 | Alyeska Investment Group, L.P. | 113,826 | 1,813,000 | 0.88% | ||
| 13 | EcoR1 Capital, LLC | 63,596 | 1,013,000 | 0.49% | ||
| 14 | STATE STREET CORP | 61,247 | 976,000 | 0.48% | ||
| 15 | AWM Investment Company, Inc. | 47,550 | 757,000 | 0.37% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 40,058 | 638,000 | 0.31% | ||
| 17 | Weiss Multi-Strategy Advisers LLC | 40,000 | 637,000 | 0.31% | ||
| 18 | NORTHERN TRUST CORP | 33,098 | 527,000 | 0.26% | ||
| 19 | Opaleye Management Inc. | 25,149 | 400,000 | 0.19% | ||
| 20 | WELLS FARGO & COMPANY/MN | 14,100 | 225,000 | 0.11% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 11,646 | 186,000 | 0.09% | ||
| 22 | Bank of New York Mellon Corp | 11,642 | 185,000 | 0.09% | ||
| 23 | MORGAN STANLEY | 10,832 | 173,000 | 0.08% | ||
| 24 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,600 | 153,000 | 0.07% | ||
| 25 | GLENMEDE TRUST CO NA | 9,324 | 148,000 | 0.07% | ||
| 26 | ARK INVESTMENT MANAGEMENT LLC | 8,245 | 131,000 | 0.06% | ||
| 27 | NEW YORK STATE COMMON RETIREMENT FUND | 5,001 | 80,000 | 0.04% | ||
| 28 | TEACHERS ADVISORS, LLC | 4,933 | 79,000 | 0.04% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 4,608 | 73,000 | 0.04% | ||
| 30 | AMERICAN INTERNATIONAL GROUP, INC. | 2,867 | 46,000 | 0.02% | ||
| 31 | Nationwide Fund Advisors | 2,008 | 32,000 | 0.02% | ||
| 32 | STRS OHIO | 1,500 | 23,000 | 0.01% | ||
| 33 | DEUTSCHE BANK AG\ | 1,153 | 18,000 | 0.01% | ||
| 34 | Creative Planning | 975 | 16,000 | 0.01% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 824 | 13,000 | 0.01% | ||
| 36 | UBS Group AG | 779 | 12,000 | 0.01% | ||
| 37 | ROYAL BANK OF CANADA | 599 | 10,000 | 0.00% | ||
| 38 | Legal & General Group Plc | 583 | 9,000 | 0.00% | ||
| 39 | Ameritas Investment Partners, Inc. | 366 | 6,000 | 0.00% | ||
| 40 | MEEDER ASSET MANAGEMENT INC | 242 | 4,000 | 0.00% | ||
| 41 | CITIGROUP INC | 124 | 2,000 | 0.00% | ||
| 42 | BNP PARIBAS FINANCIAL MARKETS | 100 | 1,593 | 0.00% | ||
| 43 | Tower Research Capital LLC (TRC) | 49 | 1,000 | 0.00% | ||
| 44 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 93 | 1,000 | 0.00% | ||
| 45 | BARCLAYS PLC | 24 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
