| 1 |
FLAGSHIP VENTURES MANAGEMENT, INC. |
4,806,656 |
66,668,000 |
37.82% |
|
|
| 2 |
FMR LLC |
3,506,155 |
48,631,000 |
27.59% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,812,778 |
25,143,000 |
14.26% |
|
|
| 4 |
Redmile Group, LLC |
892,782 |
11,736,000 |
6.66% |
|
|
| 5 |
Aisling Capital LLC |
508,565 |
7,054,000 |
4.00% |
|
|
| 6 |
BAKER BROS. ADVISORS LP |
204,465 |
2,836,000 |
1.61% |
|
|
| 7 |
EVENTIDE ASSET MANAGEMENT, LLC |
150,000 |
2,081,000 |
1.18% |
|
|
| 8 |
JPMORGAN CHASE & CO |
136,407 |
1,892,000 |
1.07% |
|
|
| 9 |
BlackRock Fund Advisors |
124,634 |
1,729,000 |
0.98% |
|
|
| 10 |
Alyeska Investment Group, L.P. |
112,637 |
1,562,000 |
0.89% |
|
|
| 11 |
EcoR1 Capital, LLC |
63,596 |
882,000 |
0.50% |
|
|
| 12 |
FORESITE CAPITAL MANAGEMENT III, LLC |
60,000 |
832,000 |
0.47% |
|
|
| 13 |
CASDIN CAPITAL, LLC |
50,000 |
694,000 |
0.39% |
|
|
| 14 |
Weiss Multi-Strategy Advisers LLC |
49,000 |
680,000 |
0.39% |
|
|
| 15 |
AWM Investment Company, Inc. |
47,550 |
660,000 |
0.37% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
34,750 |
481,000 |
0.27% |
|
|
| 17 |
MORGAN STANLEY |
33,814 |
469,000 |
0.27% |
|
|
| 18 |
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS |
30,770 |
427,000 |
0.24% |
|
|
| 19 |
GOLDMAN SACHS GROUP INC |
29,457 |
409,000 |
0.23% |
|
|
| 20 |
STATE STREET CORP |
24,979 |
347,000 |
0.20% |
|
|
| 21 |
VANGUARD GROUP INC |
15,427 |
214,000 |
0.12% |
|
|
| 22 |
HAMILTON LANE ADVISORS LLC |
13,880 |
193,000 |
0.11% |
|
|
| 23 |
Spark Investment Management LLC |
11,600 |
160,000 |
0.09% |
|
|
| 24 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
9,900 |
137,000 |
0.08% |
|
|
| 25 |
GLENMEDE TRUST CO NA |
9,324 |
129,000 |
0.07% |
|
|
| 26 |
BlackRock Institutional Trust Company, N.A. |
6,457 |
90,000 |
0.05% |
|
|
| 27 |
TEACHERS ADVISORS, LLC |
4,933 |
68,000 |
0.04% |
|
|
| 28 |
BlackRock Investment Management, LLC |
2,443 |
34,000 |
0.02% |
|
|
| 29 |
Tower Research Capital LLC (TRC) |
1,542 |
21,000 |
0.01% |
|
|
| 30 |
STRS OHIO |
1,500 |
20,000 |
0.01% |
|
|
| 31 |
CITIGROUP INC |
381 |
5,000 |
0.00% |
|
|
| 32 |
BARCLAYS PLC |
371 |
5,000 |
0.00% |
|
|
| 33 |
BNP PARIBAS FINANCIAL MARKETS |
166 |
2,302 |
0.00% |
|
|
| 34 |
Creative Planning |
175 |
2,000 |
0.00% |
|
|
| 35 |
ROYAL BANK OF CANADA |
100 |
1,000 |
0.00% |
|
|
