| 1 |
FLAGSHIP VENTURES MANAGEMENT, INC. |
4,806,656 |
58,449,000 |
37.20% |
|
|
| 2 |
FMR LLC |
3,507,070 |
42,646,000 |
27.14% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,812,778 |
22,043,000 |
14.03% |
|
|
| 4 |
Redmile Group, LLC |
948,440 |
11,533,000 |
7.34% |
|
|
| 5 |
Aisling Capital LLC |
508,565 |
6,184,000 |
3.94% |
|
|
| 6 |
BAKER BROS. ADVISORS LP |
204,465 |
2,486,000 |
1.58% |
|
|
| 7 |
CASDIN CAPITAL, LLC |
182,141 |
2,215,000 |
1.41% |
|
|
| 8 |
EVENTIDE ASSET MANAGEMENT, LLC |
150,000 |
1,824,000 |
1.16% |
|
|
| 9 |
BlackRock Fund Advisors |
144,045 |
1,752,000 |
1.11% |
|
|
| 10 |
JPMORGAN CHASE & CO |
129,118 |
1,570,000 |
1.00% |
|
|
| 11 |
Alyeska Investment Group, L.P. |
113,543 |
1,381,000 |
0.88% |
|
|
| 12 |
EcoR1 Capital, LLC |
63,596 |
773,000 |
0.49% |
|
|
| 13 |
Weiss Multi-Strategy Advisers LLC |
49,000 |
596,000 |
0.38% |
|
|
| 14 |
AWM Investment Company, Inc. |
47,550 |
578,000 |
0.37% |
|
|
| 15 |
STATE STREET CORP |
45,447 |
554,000 |
0.35% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
35,836 |
435,000 |
0.28% |
|
|
| 17 |
VANGUARD GROUP INC |
35,367 |
430,000 |
0.27% |
|
|
| 18 |
MORGAN STANLEY |
31,044 |
377,000 |
0.24% |
|
|
| 19 |
NORTHERN TRUST CORP |
27,048 |
329,000 |
0.21% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
16,249 |
198,000 |
0.13% |
|
|
| 21 |
GOLDMAN SACHS GROUP INC |
13,959 |
170,000 |
0.11% |
|
|
| 22 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
9,600 |
117,000 |
0.07% |
|
|
| 23 |
GLENMEDE TRUST CO NA |
9,324 |
113,000 |
0.07% |
|
|
| 24 |
NEW YORK STATE COMMON RETIREMENT FUND |
5,000 |
61,000 |
0.04% |
|
|
| 25 |
TEACHERS ADVISORS, LLC |
4,933 |
60,000 |
0.04% |
|
|
| 26 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
4,608 |
56,000 |
0.04% |
|
|
| 27 |
ARK INVESTMENT MANAGEMENT LLC |
3,471 |
42,000 |
0.03% |
|
|
| 28 |
BlackRock Investment Management, LLC |
3,373 |
41,000 |
0.03% |
|
|
| 29 |
DEUTSCHE BANK AG\ |
3,049 |
35,000 |
0.02% |
|
|
| 30 |
BLACKROCK ADVISORS LLC |
1,887 |
23,000 |
0.01% |
|
|
| 31 |
STRS OHIO |
1,500 |
18,000 |
0.01% |
|
|
| 32 |
UBS Group AG |
965 |
12,000 |
0.01% |
|
|
| 33 |
Creative Planning |
675 |
8,000 |
0.01% |
|
|
| 34 |
BANK OF AMERICA CORP /DE/ |
639 |
8,000 |
0.01% |
|
|
| 35 |
Legal & General Group Plc |
583 |
7,000 |
0.00% |
|
|
| 36 |
ROYAL BANK OF CANADA |
237 |
3,000 |
0.00% |
|
|
| 37 |
BlackRock Finance, Inc. |
246 |
3,000 |
0.00% |
|
|
| 38 |
BNP PARIBAS FINANCIAL MARKETS |
120 |
1,459 |
0.00% |
|
|
| 39 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
93 |
1,000 |
0.00% |
|
|
| 40 |
MEEDER ASSET MANAGEMENT INC |
96 |
1,000 |
0.00% |
|
|
| 41 |
Tower Research Capital LLC (TRC) |
29 |
0 |
0.00% |
|
|
| 42 |
BARCLAYS PLC |
32 |
0 |
0.00% |
|
|
