| 1 |
BVF INC/IL |
1,540,323 |
6,315,000 |
12.91% |
|
|
| 2 |
GREAT POINT PARTNERS LLC |
1,537,873 |
6,305,000 |
12.89% |
|
|
| 3 |
NEA Management Company, LLC |
1,298,274 |
5,323,000 |
10.88% |
|
|
| 4 |
Palo Alto Investors LP |
1,162,473 |
4,766,000 |
9.74% |
|
|
| 5 |
DAFNA Capital Management LLC |
867,529 |
3,557,000 |
7.27% |
|
|
| 6 |
BAKER BROS. ADVISORS LP |
741,665 |
3,041,000 |
6.22% |
|
|
| 7 |
VANGUARD GROUP INC |
581,940 |
2,386,000 |
4.88% |
|
|
| 8 |
Opaleye Management Inc. |
550,000 |
2,255,000 |
4.61% |
|
|
| 9 |
BOXER CAPITAL, LLC |
525,000 |
2,153,000 |
4.40% |
|
|
| 10 |
Cormorant Asset Management, LP |
520,183 |
2,133,000 |
4.36% |
|
|
| 11 |
VIVO CAPITAL, LLC |
500,000 |
2,050,000 |
4.19% |
|
|
| 12 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
360,596 |
1,478,000 |
3.02% |
|
|
| 13 |
First Eagle Investment Management, LLC |
319,480 |
1,310,000 |
2.68% |
|
|
| 14 |
Sio Capital Management, LLC |
311,925 |
1,279,000 |
2.61% |
|
|
| 15 |
SABBY MANAGEMENT, LLC |
154,162 |
632,000 |
1.29% |
|
|
| 16 |
Neuberger Berman Group LLC |
140,555 |
576,000 |
1.18% |
|
|
| 17 |
SPHERA FUNDS MANAGEMENT LTD. |
125,000 |
513,000 |
1.05% |
|
|
| 18 |
Telemetry Investments, L.L.C. |
119,881 |
492,000 |
1.01% |
|
|
| 19 |
RENAISSANCE TECHNOLOGIES LLC |
111,811 |
458,000 |
0.94% |
|
|
| 20 |
BlackRock Finance, Inc. |
82,534 |
339,000 |
0.69% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
62,353 |
255,000 |
0.52% |
|
|
| 22 |
TFS CAPITAL LLC |
38,617 |
158,000 |
0.32% |
|
|
| 23 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
37,800 |
155,000 |
0.32% |
Call |
|
| 24 |
MORGAN STANLEY |
34,080 |
139,000 |
0.28% |
|
|
| 25 |
NORTHERN TRUST CORP |
31,329 |
128,000 |
0.26% |
|
|
| 26 |
D. E. Shaw & Co., Inc. |
29,874 |
123,000 |
0.25% |
|
|
| 27 |
SIMPLEX TRADING, LLC |
23,655 |
96,000 |
0.20% |
|
|
| 28 |
WELLS FARGO & COMPANY/MN |
23,597 |
96,000 |
0.20% |
|
|
| 29 |
BOOTHBAY FUND MANAGEMENT, LLC |
19,857 |
81,000 |
0.17% |
|
|
| 30 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
19,416 |
80,000 |
0.16% |
|
|
| 31 |
WOLVERINE TRADING LP /BD |
14,372 |
59,000 |
0.12% |
|
|
| 32 |
MILLENNIUM MANAGEMENT LLC |
13,673 |
56,000 |
0.11% |
|
|
| 33 |
WOLVERINE TRADING LP /BD |
13,700 |
56,000 |
0.11% |
Call |
|
| 34 |
WOLVERINE TRADING LP /BD |
12,400 |
51,000 |
0.10% |
Put |
|
| 35 |
BANK OF AMERICA CORP /DE/ |
4,391 |
18,000 |
0.04% |
|
|
| 36 |
Tower Research Capital LLC (TRC) |
2,324 |
10,000 |
0.02% |
|
|
| 37 |
UBS Group AG |
900 |
4,000 |
0.01% |
|
|
| 38 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
318 |
1,000 |
0.00% |
|
|
| 39 |
Hanson & Doremus Investment Management |
166 |
1,000 |
0.00% |
|
|
| 40 |
TCI Wealth Advisors, Inc. |
23 |
0 |
0.00% |
|
|
| 41 |
GROUP ONE TRADING LLC |
26 |
0 |
0.00% |
|
|
| 42 |
BRONFMAN E.L. ROTHSCHILD, L.P. |
13 |
0 |
0.00% |
|
|
| 43 |
SEI INVESTMENTS CO |
50 |
0 |
0.00% |
|
|
| 44 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
16 |
0 |
0.00% |
|
|
| 45 |
DEUTSCHE BANK AG\ |
222 |
0 |
0.00% |
|
|
| 46 |
Winfield Associates, Inc. |
35 |
0 |
0.00% |
|
|
