| 1 |
NEA Management Company, LLC |
1,298,274 |
5,673,000 |
18.71% |
|
|
| 2 |
Palo Alto Investors LP |
1,162,473 |
5,080,000 |
16.75% |
|
|
| 3 |
GREAT POINT PARTNERS LLC |
1,063,573 |
4,648,000 |
15.33% |
|
|
| 4 |
BAKER BROS. ADVISORS LP |
741,665 |
3,241,000 |
10.69% |
|
|
| 5 |
BVF INC/IL |
730,361 |
3,192,000 |
10.53% |
|
|
| 6 |
VANGUARD GROUP INC |
391,611 |
1,711,000 |
5.64% |
|
|
| 7 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
327,222 |
1,430,000 |
4.72% |
|
|
| 8 |
First Eagle Investment Management, LLC |
249,999 |
1,092,000 |
3.60% |
|
|
| 9 |
Healthcare Value Capital, LLC |
150,000 |
656,000 |
2.16% |
Call |
|
| 10 |
Frontier Wealth Management LLC |
133,300 |
583,000 |
1.92% |
|
|
| 11 |
FEDERATED HERMES, INC. |
110,000 |
481,000 |
1.59% |
|
|
| 12 |
RENAISSANCE TECHNOLOGIES LLC |
94,581 |
413,000 |
1.36% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
76,616 |
335,000 |
1.10% |
|
|
| 14 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
65,300 |
285,000 |
0.94% |
Put |
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
56,674 |
247,000 |
0.81% |
|
|
| 16 |
WOLVERINE TRADING LP /BD |
34,900 |
151,000 |
0.50% |
Put |
|
| 17 |
FRANKLIN STREET ADVISORS INC /NC |
33,332 |
146,000 |
0.48% |
|
|
| 18 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
23,000 |
101,000 |
0.33% |
Call |
|
| 19 |
GUGGENHEIM CAPITAL LLC |
22,301 |
97,000 |
0.32% |
|
|
| 20 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
19,416 |
85,000 |
0.28% |
|
|
| 21 |
Virtu KCG Holdings LLC |
17,766 |
78,000 |
0.26% |
|
|
| 22 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
17,431 |
76,000 |
0.25% |
|
|
| 23 |
GROUP ONE TRADING LLC |
16,432 |
72,000 |
0.24% |
|
|
| 24 |
D. E. Shaw & Co., Inc. |
16,377 |
72,000 |
0.24% |
|
|
| 25 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
16,418 |
72,000 |
0.24% |
|
|
| 26 |
BOOTHBAY FUND MANAGEMENT, LLC |
15,999 |
70,000 |
0.23% |
|
|
| 27 |
NORTHERN TRUST CORP |
15,688 |
69,000 |
0.23% |
|
|
| 28 |
WOLVERINE TRADING LP /BD |
13,800 |
60,000 |
0.20% |
Call |
|
| 29 |
WELLS FARGO & COMPANY/MN |
9,442 |
41,000 |
0.14% |
|
|
| 30 |
MORGAN STANLEY |
4,972 |
22,000 |
0.07% |
|
|
| 31 |
BlackRock Fund Advisors |
2,525 |
11,000 |
0.04% |
|
|
| 32 |
BLACKROCK ADVISORS LLC |
2,343 |
10,000 |
0.03% |
|
|
| 33 |
JPMORGAN CHASE & CO |
1,805 |
8,000 |
0.03% |
|
|
| 34 |
CITIGROUP INC |
1,296 |
6,000 |
0.02% |
Call |
|
| 35 |
UBS Group AG |
888 |
4,000 |
0.01% |
|
|
| 36 |
ROYAL BANK OF CANADA |
267 |
1,000 |
0.00% |
|
|
| 37 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
318 |
1,000 |
0.00% |
|
|
| 38 |
CUTLER GROUP LLC / CA |
186 |
0 |
0.00% |
|
|
| 39 |
SEI INVESTMENTS CO |
50 |
0 |
0.00% |
|
|
| 40 |
JNBA Financial Advisors |
55 |
0 |
0.00% |
|
|
| 41 |
BARCLAYS PLC |
13 |
0 |
0.00% |
|
|
| 42 |
Winfield Associates, Inc. |
35 |
0 |
0.00% |
|
|
| 43 |
TCI Wealth Advisors, Inc. |
23 |
0 |
0.00% |
|
|
| 44 |
REILLY FINANCIAL ADVISORS, LLC |
83 |
0 |
0.00% |
|
|
| 45 |
BRONFMAN E.L. ROTHSCHILD, L.P. |
13 |
0 |
0.00% |
|
|
| 46 |
SIGNATUREFD, LLC |
55 |
0 |
0.00% |
|
|
| 47 |
DEUTSCHE BANK AG\ |
2 |
0 |
0.00% |
|
|
| 48 |
CUTLER GROUP LLC / CA |
4,600 |
0 |
0.00% |
Call |
|
