| 1 |
GREAT POINT PARTNERS LLC |
1,537,873 |
5,567,000 |
12.71% |
|
|
| 2 |
BVF INC/IL |
1,392,720 |
5,042,000 |
11.51% |
|
|
| 3 |
NEA Management Company, LLC |
1,298,274 |
4,700,000 |
10.73% |
|
|
| 4 |
Palo Alto Investors LP |
1,162,473 |
4,208,000 |
9.61% |
|
|
| 5 |
DAFNA Capital Management LLC |
1,133,583 |
4,104,000 |
9.37% |
|
|
| 6 |
Cormorant Asset Management, LP |
1,000,000 |
3,620,000 |
8.26% |
|
|
| 7 |
BAKER BROS. ADVISORS LP |
741,665 |
2,685,000 |
6.13% |
|
|
| 8 |
First Eagle Investment Management, LLC |
574,999 |
2,081,000 |
4.75% |
|
|
| 9 |
BOXER CAPITAL, LLC |
525,000 |
1,901,000 |
4.34% |
|
|
| 10 |
VIVO CAPITAL, LLC |
500,000 |
1,810,000 |
4.13% |
|
|
| 11 |
VANGUARD GROUP INC |
430,946 |
1,560,000 |
3.56% |
|
|
| 12 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
423,711 |
1,534,000 |
3.50% |
|
|
| 13 |
SABBY MANAGEMENT, LLC |
221,326 |
801,000 |
1.83% |
|
|
| 14 |
Healthcare Value Capital, LLC |
150,000 |
543,000 |
1.24% |
Call |
|
| 15 |
SPHERA FUNDS MANAGEMENT LTD. |
125,000 |
453,000 |
1.03% |
|
|
| 16 |
Telemetry Investments, L.L.C. |
120,807 |
437,000 |
1.00% |
|
|
| 17 |
Neuberger Berman Group LLC |
120,555 |
436,000 |
1.00% |
|
|
| 18 |
RENAISSANCE TECHNOLOGIES LLC |
110,581 |
400,000 |
0.91% |
|
|
| 19 |
FEDERATED HERMES, INC. |
110,000 |
398,000 |
0.91% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
76,616 |
277,000 |
0.63% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
56,782 |
205,000 |
0.47% |
|
|
| 22 |
FRANKLIN STREET ADVISORS INC /NC |
33,332 |
121,000 |
0.28% |
|
|
| 23 |
WOLVERINE TRADING LP /BD |
31,200 |
113,000 |
0.26% |
Put |
|
| 24 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
30,400 |
110,000 |
0.25% |
Call |
|
| 25 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
30,000 |
109,000 |
0.25% |
Put |
|
| 26 |
D. E. Shaw & Co., Inc. |
24,179 |
87,000 |
0.20% |
|
|
| 27 |
NORTHERN TRUST CORP |
24,178 |
87,000 |
0.20% |
|
|
| 28 |
BOOTHBAY FUND MANAGEMENT, LLC |
19,857 |
72,000 |
0.16% |
|
|
| 29 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
19,416 |
70,000 |
0.16% |
|
|
| 30 |
WELLS FARGO & COMPANY/MN |
16,142 |
58,000 |
0.13% |
|
|
| 31 |
GROUP ONE TRADING LLC |
14,433 |
52,000 |
0.12% |
|
|
| 32 |
Virtu KCG Holdings LLC |
13,048 |
47,000 |
0.11% |
|
|
| 33 |
Tower Research Capital LLC (TRC) |
7,499 |
27,000 |
0.06% |
|
|
| 34 |
Creative Planning |
5,000 |
18,000 |
0.04% |
|
|
| 35 |
JPMORGAN CHASE & CO |
4,220 |
15,000 |
0.03% |
|
|
| 36 |
MORGAN STANLEY |
3,926 |
14,000 |
0.03% |
|
|
| 37 |
BlackRock Fund Advisors |
3,048 |
11,000 |
0.03% |
|
|
| 38 |
BLACKROCK ADVISORS LLC |
2,343 |
8,000 |
0.02% |
|
|
| 39 |
UBS Group AG |
2,034 |
7,000 |
0.02% |
|
|
| 40 |
ELGETHUN CAPITAL MANAGEMENT |
1,332 |
5,000 |
0.01% |
|
|
| 41 |
BANK OF AMERICA CORP /DE/ |
1,000 |
4,000 |
0.01% |
|
|
| 42 |
CITIGROUP INC |
976 |
4,000 |
0.01% |
Call |
|
| 43 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
318 |
1,000 |
0.00% |
|
|
| 44 |
Hanson & Doremus Investment Management |
166 |
601 |
0.00% |
|
|
| 45 |
DEUTSCHE BANK AG\ |
2 |
0 |
0.00% |
|
|
| 46 |
CUTLER GROUP LLC / CA |
186 |
0 |
0.00% |
|
|
| 47 |
CUTLER GROUP LLC / CA |
4,600 |
0 |
0.00% |
Call |
|
| 48 |
Winfield Associates, Inc. |
35 |
0 |
0.00% |
|
|
| 49 |
TCI Wealth Advisors, Inc. |
23 |
0 |
0.00% |
|
|
| 50 |
SEI INVESTMENTS CO |
50 |
0 |
0.00% |
|
|
