| 1 |
FMR LLC |
2,518,198 |
32,258,000 |
31.44% |
|
|
| 2 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,656,076 |
21,214,000 |
20.68% |
|
|
| 3 |
PHARMSTANDARD INTERNATIONAL S.A. |
982,270 |
12,583,000 |
12.27% |
|
|
| 4 |
Cormorant Asset Management, LP |
683,600 |
8,757,000 |
8.54% |
|
|
| 5 |
RA CAPITAL MANAGEMENT, L.P. |
636,248 |
8,150,000 |
7.94% |
|
|
| 6 |
FORESITE CAPITAL MANAGEMENT III, LLC |
346,281 |
4,436,000 |
4.32% |
|
|
| 7 |
BlackRock Finance, Inc. |
345,645 |
4,427,000 |
4.32% |
|
|
| 8 |
VANGUARD GROUP INC |
313,514 |
4,016,000 |
3.91% |
|
|
| 9 |
GEODE CAPITAL MANAGEMENT, LLC |
101,218 |
1,296,000 |
1.26% |
|
|
| 10 |
STATE STREET CORP |
93,063 |
1,192,000 |
1.16% |
|
|
| 11 |
NORTHERN TRUST CORP |
79,666 |
1,020,000 |
0.99% |
|
|
| 12 |
GRATICULE ASIA MACRO ADVISORS LLC |
31,827 |
408,000 |
0.40% |
|
|
| 13 |
Spark Investment Management LLC |
31,500 |
403,000 |
0.39% |
|
|
| 14 |
Bank of New York Mellon Corp |
26,148 |
335,000 |
0.33% |
|
|
| 15 |
Polar Capital LLP |
25,000 |
320,000 |
0.31% |
|
|
| 16 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
19,560 |
251,000 |
0.24% |
|
|
| 17 |
PDT Partners, LLC |
18,000 |
231,000 |
0.23% |
|
|
| 18 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
15,300 |
196,000 |
0.19% |
|
|
| 19 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13,200 |
170,000 |
0.17% |
|
|
| 20 |
MORGAN STANLEY |
9,901 |
127,000 |
0.12% |
|
|
| 21 |
TEACHERS ADVISORS, LLC |
9,461 |
121,000 |
0.12% |
|
|
| 22 |
JPMORGAN CHASE & CO |
9,197 |
118,000 |
0.12% |
|
|
| 23 |
NEW YORK STATE COMMON RETIREMENT FUND |
7,601 |
97,000 |
0.09% |
|
|
| 24 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
7,227 |
93,000 |
0.09% |
|
|
| 25 |
DEUTSCHE BANK AG\ |
6,556 |
83,000 |
0.08% |
|
|
| 26 |
WELLS FARGO & COMPANY/MN |
5,219 |
67,000 |
0.07% |
|
|
| 27 |
AMERICAN INTERNATIONAL GROUP, INC. |
4,564 |
58,000 |
0.06% |
|
|
| 28 |
Nationwide Fund Advisors |
4,345 |
56,000 |
0.05% |
|
|
| 29 |
STRS OHIO |
2,400 |
30,000 |
0.03% |
|
|
| 30 |
BARCLAYS PLC |
1,635 |
20,000 |
0.02% |
|
|
| 31 |
BANK OF AMERICA CORP /DE/ |
1,343 |
17,000 |
0.02% |
|
|
| 32 |
Legal & General Group Plc |
1,027 |
13,000 |
0.01% |
|
|
| 33 |
Tower Research Capital LLC (TRC) |
656 |
9,000 |
0.01% |
|
|
| 34 |
Ameritas Investment Partners, Inc. |
514 |
7,000 |
0.01% |
|
|
| 35 |
UBS Group AG |
329 |
4,000 |
0.00% |
|
|
| 36 |
ROYAL BANK OF CANADA |
243 |
3,000 |
0.00% |
|
|
| 37 |
CITIGROUP INC |
144 |
2,000 |
0.00% |
|
|
| 38 |
Creative Planning |
177 |
2,000 |
0.00% |
|
|
| 39 |
MEEDER ASSET MANAGEMENT INC |
54 |
1,000 |
0.00% |
|
|
| 40 |
BNP PARIBAS FINANCIAL MARKETS |
21 |
269 |
0.00% |
|
|
