| 1 |
FMR LLC |
2,507,167 |
55,133,000 |
31.54% |
|
|
| 2 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,531,076 |
33,668,000 |
19.26% |
|
|
| 3 |
PHARMSTANDARD INTERNATIONAL S.A. |
983,570 |
21,628,000 |
12.37% |
|
|
| 4 |
Cormorant Asset Management, LP |
720,000 |
15,833,000 |
9.06% |
|
|
| 5 |
RA CAPITAL MANAGEMENT, L.P. |
692,563 |
14,634,000 |
8.37% |
|
|
| 6 |
FORESITE CAPITAL MANAGEMENT III, LLC |
346,281 |
7,615,000 |
4.36% |
|
|
| 7 |
VANGUARD GROUP INC |
310,079 |
6,818,000 |
3.90% |
|
|
| 8 |
BlackRock Fund Advisors |
244,386 |
5,374,000 |
3.07% |
|
|
| 9 |
GEODE CAPITAL MANAGEMENT, LLC |
99,368 |
2,185,000 |
1.25% |
|
|
| 10 |
STATE STREET CORP |
92,163 |
2,028,000 |
1.16% |
|
|
| 11 |
NORTHERN TRUST CORP |
82,180 |
1,807,000 |
1.03% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
72,987 |
1,605,000 |
0.92% |
|
|
| 13 |
DAFNA Capital Management LLC |
45,586 |
1,002,000 |
0.57% |
|
|
| 14 |
GRATICULE ASIA MACRO ADVISORS LLC |
31,827 |
700,000 |
0.40% |
|
|
| 15 |
Spark Investment Management LLC |
31,500 |
692,000 |
0.40% |
|
|
| 16 |
BlackRock Investment Management, LLC |
29,930 |
658,000 |
0.38% |
|
|
| 17 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
22,918 |
504,000 |
0.29% |
|
|
| 18 |
MORGAN STANLEY |
22,778 |
501,000 |
0.29% |
|
|
| 19 |
Bank of New York Mellon Corp |
22,715 |
500,000 |
0.29% |
|
|
| 20 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
15,700 |
345,000 |
0.20% |
|
|
| 21 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13,200 |
291,000 |
0.17% |
|
|
| 22 |
JPMORGAN CHASE & CO |
10,610 |
233,000 |
0.13% |
|
|
| 23 |
TEACHERS ADVISORS, LLC |
9,461 |
208,000 |
0.12% |
|
|
| 24 |
CITIGROUP INC |
7,644 |
168,000 |
0.10% |
|
|
| 25 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
5,746 |
126,000 |
0.07% |
|
|
| 26 |
WELLS FARGO & COMPANY/MN |
5,219 |
115,000 |
0.07% |
|
|
| 27 |
Nationwide Fund Advisors |
4,934 |
108,000 |
0.06% |
|
|
| 28 |
DEUTSCHE BANK AG\ |
4,343 |
94,000 |
0.05% |
|
|
| 29 |
BLACKROCK ADVISORS LLC |
2,758 |
61,000 |
0.03% |
|
|
| 30 |
STRS OHIO |
2,400 |
52,000 |
0.03% |
|
|
| 31 |
UBS Group AG |
1,443 |
32,000 |
0.02% |
|
|
| 32 |
Legal & General Group Plc |
1,343 |
30,000 |
0.02% |
|
|
| 33 |
BANK OF AMERICA CORP /DE/ |
1,043 |
23,000 |
0.01% |
|
|
| 34 |
Creative Planning |
677 |
15,000 |
0.01% |
|
|
| 35 |
ROYAL BANK OF CANADA |
357 |
8,000 |
0.00% |
|
|
| 36 |
BNP PARIBAS FINANCIAL MARKETS |
363 |
7,982 |
0.00% |
|
|
| 37 |
BlackRock Finance, Inc. |
262 |
6,000 |
0.00% |
|
|
| 38 |
BARCLAYS PLC |
218 |
5,000 |
0.00% |
|
|
