| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,128,719 | 44,980,000 | 31.05% | ||
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,581,076 | 33,408,000 | 23.06% | ||
| 3 | Cormorant Asset Management, LP | 800,000 | 16,904,000 | 11.67% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 754,411 | 15,941,000 | 11.01% | ||
| 5 | BVF INC/IL | 375,000 | 7,924,000 | 5.47% | ||
| 6 | FORESITE CAPITAL MANAGEMENT III, LLC | 346,281 | 6,285,000 | 4.34% | ||
| 7 | BlackRock Fund Advisors | 206,455 | 4,362,000 | 3.01% | ||
| 8 | VANGUARD GROUP INC | 142,468 | 3,011,000 | 2.08% | ||
| 9 | DAFNA Capital Management LLC | 123,804 | 2,616,000 | 1.81% | ||
| 10 | GEODE CAPITAL MANAGEMENT, LLC | 92,820 | 1,960,000 | 1.35% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 66,262 | 1,400,000 | 0.97% | ||
| 12 | STATE STREET CORP | 61,121 | 1,292,000 | 0.89% | ||
| 13 | Spark Investment Management LLC | 42,100 | 889,000 | 0.61% | ||
| 14 | GRATICULE ASIA MACRO ADVISORS LLC | 31,827 | 673,000 | 0.46% | ||
| 15 | BlackRock Investment Management, LLC | 28,898 | 611,000 | 0.42% | ||
| 16 | NORTHERN TRUST CORP | 20,137 | 425,000 | 0.29% | ||
| 17 | CREDIT SUISSE AG/ | 16,924 | 358,000 | 0.25% | ||
| 18 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 16,100 | 340,000 | 0.23% | ||
| 19 | Bank of New York Mellon Corp | 14,202 | 301,000 | 0.21% | ||
| 20 | GOLDMAN SACHS GROUP INC | 13,340 | 282,000 | 0.19% | ||
| 21 | JANE STREET GROUP, LLC | 10,964 | 232,000 | 0.16% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 10,093 | 213,000 | 0.15% | ||
| 23 | TEACHERS ADVISORS, LLC | 8,037 | 170,000 | 0.12% | ||
| 24 | BLACKROCK ADVISORS LLC | 2,605 | 55,000 | 0.04% | ||
| 25 | STRS OHIO | 2,400 | 50,000 | 0.03% | ||
| 26 | JPMORGAN CHASE & CO | 2,108 | 45,000 | 0.03% | ||
| 27 | Nationwide Fund Advisors | 2,101 | 44,000 | 0.03% | ||
| 28 | DEUTSCHE BANK AG\ | 1,270 | 26,000 | 0.02% | ||
| 29 | UBS Group AG | 1,069 | 23,000 | 0.02% | ||
| 30 | CITIGROUP INC | 621 | 13,000 | 0.01% | ||
| 31 | BNP PARIBAS FINANCIAL MARKETS | 271 | 5,726 | 0.00% | ||
| 32 | MORGAN STANLEY | 200 | 4,000 | 0.00% | ||
| 33 | ROYAL BANK OF CANADA | 200 | 4,000 | 0.00% | ||
| 34 | Creative Planning | 177 | 4,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
