| 1 |
PFM Health Sciences, LP |
341,628 |
9,231,000 |
14.39% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
334,342 |
9,034,000 |
14.08% |
|
|
| 3 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
262,625 |
7,096,000 |
11.06% |
|
|
| 4 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
230,072 |
6,217,000 |
9.69% |
|
|
| 5 |
Abingworth LLP |
200,000 |
5,376,000 |
8.38% |
|
|
| 6 |
VANGUARD GROUP INC |
174,505 |
4,715,000 |
7.35% |
|
|
| 7 |
WADDELL & REED FINANCIAL INC |
150,000 |
4,053,000 |
6.32% |
|
|
| 8 |
BlackRock Fund Advisors |
141,221 |
3,816,000 |
5.95% |
|
|
| 9 |
Informed Momentum Co LLC |
64,775 |
1,750,000 |
2.73% |
|
|
| 10 |
GEODE CAPITAL MANAGEMENT, LLC |
58,829 |
1,589,000 |
2.48% |
|
|
| 11 |
STATE STREET CORP |
47,184 |
1,274,000 |
1.99% |
|
|
| 12 |
NORTHERN TRUST CORP |
45,869 |
1,240,000 |
1.93% |
|
|
| 13 |
Anson Funds Management LP |
40,986 |
1,107,000 |
1.73% |
|
|
| 14 |
Nicholas Investment Partners, LP |
38,629 |
1,041,000 |
1.62% |
|
|
| 15 |
CITIGROUP INC |
32,530 |
879,000 |
1.37% |
|
|
| 16 |
Prospera Financial Services Inc |
24,778 |
669,000 |
1.04% |
|
|
| 17 |
RUSSELL INVESTMENTS GROUP, LTD. |
21,621 |
551,000 |
0.86% |
|
|
| 18 |
Spark Investment Management LLC |
19,700 |
532,000 |
0.83% |
|
|
| 19 |
Bank of New York Mellon Corp |
18,436 |
498,000 |
0.78% |
|
|
| 20 |
ALPS ADVISORS INC |
15,318 |
414,000 |
0.65% |
|
|
| 21 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
14,944 |
404,000 |
0.63% |
|
|
| 22 |
MORGAN STANLEY |
13,889 |
375,000 |
0.58% |
|
|
| 23 |
Geduld E E |
10,000 |
270,000 |
0.42% |
|
|
| 24 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
9,800 |
265,000 |
0.41% |
|
|
| 25 |
WALL STREET ASSOCIATES |
8,441 |
228,000 |
0.36% |
|
|
| 26 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
8,351 |
226,000 |
0.35% |
|
|
| 27 |
BlackRock Institutional Trust Company, N.A. |
8,188 |
221,000 |
0.34% |
|
|
| 28 |
Partner Investment Management, L.P. |
6,923 |
187,000 |
0.29% |
|
|
| 29 |
JPMORGAN CHASE & CO |
6,672 |
180,000 |
0.28% |
|
|
| 30 |
TEACHERS ADVISORS, LLC |
5,183 |
140,000 |
0.22% |
|
|
| 31 |
BlackRock Investment Management, LLC |
3,185 |
86,000 |
0.13% |
|
|
| 32 |
DEUTSCHE BANK AG\ |
2,842 |
75,000 |
0.12% |
|
|
| 33 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,648 |
72,000 |
0.11% |
|
|
| 34 |
NEW YORK STATE COMMON RETIREMENT FUND |
2,646 |
71,000 |
0.11% |
|
|
| 35 |
BLACKROCK ADVISORS LLC |
1,810 |
49,000 |
0.08% |
|
|
| 36 |
WELLS FARGO & COMPANY/MN |
1,719 |
46,000 |
0.07% |
|
|
| 37 |
STRS OHIO |
1,500 |
40,000 |
0.06% |
|
|
| 38 |
UBS Group AG |
1,270 |
35,000 |
0.05% |
|
|
| 39 |
Tower Research Capital LLC (TRC) |
970 |
26,000 |
0.04% |
|
|
| 40 |
BELL ROCK CAPITAL LLC |
900 |
24,000 |
0.04% |
|
|
| 41 |
BANK OF AMERICA CORP /DE/ |
812 |
22,000 |
0.03% |
|
|
| 42 |
Legal & General Group Plc |
727 |
19,000 |
0.03% |
|
|
| 43 |
BNP PARIBAS FINANCIAL MARKETS |
262 |
7,079 |
0.01% |
|
|
| 44 |
BlackRock Finance, Inc. |
268 |
7,000 |
0.01% |
|
|
| 45 |
ROYAL BANK OF CANADA |
236 |
6,000 |
0.01% |
|
|
| 46 |
BARCLAYS PLC |
22 |
1,000 |
0.00% |
|
|
| 47 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
0 |
0 |
0.00% |
|
|
