| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | QVT Financial LP | 16,013,540 | 189,921,000 | 42.32% | ||
| 2 | Alpha Wave Global, LP | 2,618,000 | 31,049,000 | 6.92% | ||
| 3 | PRIMECAP MANAGEMENT CO/CA/ | 2,080,000 | 24,669,000 | 5.50% | ||
| 4 | FRANKLIN RESOURCES INC | 2,056,300 | 24,388,000 | 5.43% | ||
| 5 | D. E. Shaw & Co., Inc. | 2,014,612 | 23,894,000 | 5.32% | ||
| 6 | HealthCor Management, L.P. | 1,725,000 | 20,459,000 | 4.56% | ||
| 7 | Blue Ridge Capital, L.L.C. | 1,700,000 | 20,162,000 | 4.49% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 1,363,025 | 16,165,000 | 3.60% | ||
| 9 | RS INVESTMENT MANAGEMENT CO LLC | 972,540 | 11,534,000 | 2.57% | ||
| 10 | BANK OF MONTREAL /CAN/ | 775,803 | 9,201,000 | 2.05% | ||
| 11 | GOLDMAN SACHS GROUP INC | 773,578 | 9,175,000 | 2.04% | ||
| 12 | Global X Management CO LLC | 434,303 | 5,151,000 | 1.15% | ||
| 13 | Invesco Ltd. | 430,408 | 5,104,000 | 1.14% | ||
| 14 | AXA S.A. | 421,745 | 5,002,000 | 1.11% | ||
| 15 | ASCEND CAPITAL, LLC | 370,400 | 4,393,000 | 0.98% | ||
| 16 | Point72 Asset Management, L.P. | 360,800 | 4,279,000 | 0.95% | ||
| 17 | CITADEL ADVISORS LLC | 357,388 | 4,238,000 | 0.94% | ||
| 18 | EverPoint Asset Management, LLC | 320,000 | 3,795,000 | 0.85% | ||
| 19 | SABBY MANAGEMENT, LLC | 305,351 | 3,621,000 | 0.81% | ||
| 20 | SPHERA FUNDS MANAGEMENT LTD. | 255,000 | 3,024,000 | 0.67% | ||
| 21 | BNP Paribas Asset Management Holding S.A. | 212,934 | 2,525,000 | 0.56% | ||
| 22 | MARINER INVESTMENT GROUP LLC | 201,100 | 2,385,000 | 0.53% | ||
| 23 | Candriam S.C.A. | 182,000 | 2,159,000 | 0.48% | ||
| 24 | BAKER BROS. ADVISORS LP | 180,582 | 2,142,000 | 0.48% | ||
| 25 | CREDIT SUISSE AG/ | 145,182 | 1,721,000 | 0.38% | ||
| 26 | BAILARD, INC. | 139,000 | 1,649,000 | 0.37% | ||
| 27 | BELLEVUE ASSET MANAGEMENT AG | 125,000 | 1,483,000 | 0.33% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 102,100 | 1,211,000 | 0.27% | Call | |
| 29 | MORGAN STANLEY | 99,280 | 1,178,000 | 0.26% | ||
| 30 | SIT INVESTMENT ASSOCIATES INC | 71,200 | 844,000 | 0.19% | ||
| 31 | AMERIPRISE FINANCIAL INC | 68,571 | 813,000 | 0.18% | ||
| 32 | GROUP ONE TRADING LLC | 68,428 | 812,000 | 0.18% | ||
| 33 | ROYAL BANK OF CANADA | 68,060 | 808,000 | 0.18% | ||
| 34 | Corvex Management LP | 66,900 | 793,000 | 0.18% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 65,300 | 774,000 | 0.17% | Put | |
| 36 | Telemetry Investments, L.L.C. | 56,500 | 670,000 | 0.15% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 50,000 | 593,000 | 0.13% | Put | |
| 38 | BANK OF AMERICA CORP /DE/ | 50,000 | 593,000 | 0.13% | Call | |
| 39 | DEUTSCHE BANK AG\ | 43,100 | 510,000 | 0.11% | ||
| 40 | K2 PRINCIPAL FUND, L.P. | 42,635 | 506,000 | 0.11% | ||
| 41 | CITIGROUP INC | 42,182 | 501,000 | 0.11% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 40,114 | 476,000 | 0.11% | ||
| 43 | MACKENZIE FINANCIAL CORP | 39,900 | 473,000 | 0.11% | ||
| 44 | CANADA LIFE ASSURANCE Co | 39,900 | 473,000 | 0.11% | ||
| 45 | BANK OF AMERICA CORP /DE/ | 27,174 | 322,000 | 0.07% | ||
| 46 | Stanley-Laman Group, Ltd. | 25,722 | 305,000 | 0.07% | ||
| 47 | Anson Funds Management LP | 25,000 | 297,000 | 0.07% | ||
| 48 | JPMORGAN CHASE & CO | 21,347 | 253,000 | 0.06% | ||
| 49 | PDT Partners, LLC | 20,794 | 247,000 | 0.06% | ||
| 50 | NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 20,291 | 241,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
