| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | QVT Financial LP | 16,013,540 | 279,596,000 | 45.14% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 2,714,800 | 47,400,000 | 7.65% | ||
| 3 | Alpha Wave Global, LP | 2,221,000 | 38,779,000 | 6.26% | ||
| 4 | FRANKLIN RESOURCES INC | 1,984,900 | 34,656,000 | 5.60% | ||
| 5 | Blue Ridge Capital, L.L.C. | 1,700,000 | 29,682,000 | 4.79% | ||
| 6 | D. E. Shaw & Co., Inc. | 1,681,900 | 29,366,000 | 4.74% | ||
| 7 | BANK OF MONTREAL /CAN/ | 754,723 | 13,177,000 | 2.13% | ||
| 8 | HealthCor Management, L.P. | 718,800 | 12,550,000 | 2.03% | ||
| 9 | Redmile Group, LLC | 700,000 | 12,222,000 | 1.97% | ||
| 10 | RS INVESTMENT MANAGEMENT CO LLC | 576,140 | 10,059,000 | 1.62% | ||
| 11 | PRIMECAP MANAGEMENT CO/CA/ | 548,603 | 9,579,000 | 1.55% | ||
| 12 | GOLDMAN SACHS GROUP INC | 490,782 | 8,569,000 | 1.38% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 374,757 | 6,543,000 | 1.06% | ||
| 14 | CITADEL ADVISORS LLC | 360,525 | 6,295,000 | 1.02% | ||
| 15 | BNP Paribas Asset Management Holding S.A. | 334,175 | 5,835,000 | 0.94% | ||
| 16 | Invesco Ltd. | 304,766 | 5,321,000 | 0.86% | ||
| 17 | SPHERA FUNDS MANAGEMENT LTD. | 298,486 | 5,212,000 | 0.84% | ||
| 18 | HIGHLAND CAPITAL MANAGEMENT LP | 286,153 | 4,996,000 | 0.81% | ||
| 19 | Tourbillon Capital Partners, L.P. | 275,000 | 4,802,000 | 0.78% | ||
| 20 | AXA S.A. | 250,801 | 4,379,000 | 0.71% | ||
| 21 | CANADA PENSION PLAN INVESTMENT BOARD | 233,800 | 4,082,000 | 0.66% | ||
| 22 | Candriam S.C.A. | 182,000 | 3,178,000 | 0.51% | ||
| 23 | BAKER BROS. ADVISORS LP | 180,582 | 3,153,000 | 0.51% | ||
| 24 | SABBY MANAGEMENT, LLC | 170,821 | 2,983,000 | 0.48% | ||
| 25 | Point72 Asset Management, L.P. | 157,200 | 2,745,000 | 0.44% | ||
| 26 | ARROWGRASS CAPITAL PARTNERS (US) LP | 155,000 | 2,706,000 | 0.44% | ||
| 27 | BAILARD, INC. | 139,000 | 2,427,000 | 0.39% | ||
| 28 | Corvex Management LP | 131,900 | 2,303,000 | 0.37% | ||
| 29 | DRIEHAUS CAPITAL MANAGEMENT LLC | 131,736 | 2,300,000 | 0.37% | ||
| 30 | SUFFOLK CAPITAL MANAGEMENT LLC | 118,100 | 2,062,000 | 0.33% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 97,800 | 1,708,000 | 0.28% | Call | |
| 32 | CITIGROUP INC | 87,952 | 1,536,000 | 0.25% | ||
| 33 | CREDIT SUISSE AG/ | 81,819 | 1,428,000 | 0.23% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 72,000 | 1,257,000 | 0.20% | Put | |
| 35 | SIT INVESTMENT ASSOCIATES INC | 71,200 | 1,243,000 | 0.20% | ||
| 36 | AMERIPRISE FINANCIAL INC | 65,240 | 1,138,000 | 0.18% | ||
| 37 | MARINER INVESTMENT GROUP LLC | 65,000 | 1,135,000 | 0.18% | ||
| 38 | MONASHEE INVESTMENT MANAGEMENT LLC | 55,000 | 960,000 | 0.16% | ||
| 39 | WALL STREET ASSOCIATES | 53,338 | 931,000 | 0.15% | ||
| 40 | Telemetry Investments, L.L.C. | 48,000 | 838,000 | 0.14% | ||
| 41 | TORONTO DOMINION BANK | 45,000 | 786,000 | 0.13% | Put | |
| 42 | DEUTSCHE BANK AG\ | 42,300 | 738,000 | 0.12% | ||
| 43 | MACKENZIE FINANCIAL CORP | 39,900 | 697,000 | 0.11% | ||
| 44 | CANADA LIFE ASSURANCE Co | 39,900 | 695,000 | 0.11% | ||
| 45 | MORGAN STANLEY | 38,082 | 665,000 | 0.11% | ||
| 46 | TORONTO DOMINION BANK | 37,000 | 646,000 | 0.10% | ||
| 47 | GUGGENHEIM CAPITAL LLC | 36,000 | 628,000 | 0.10% | ||
| 48 | BARCLAYS PLC | 34,818 | 592,000 | 0.10% | ||
| 49 | ROYAL BANK OF CANADA | 32,927 | 575,000 | 0.09% | ||
| 50 | Visium Asset Management, LP | 30,000 | 524,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
