| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 3,581,900 | 191,739,000 | 9.33% | ||
| 2 | Capital World Investors | 3,488,100 | 177,579,000 | 8.64% | ||
| 3 | VANGUARD GROUP INC | 2,155,325 | 115,375,000 | 5.62% | ||
| 4 | BlackRock Fund Advisors | 1,789,640 | 95,799,000 | 4.66% | ||
| 5 | JENNISON ASSOCIATES LLC | 1,690,766 | 90,507,000 | 4.41% | ||
| 6 | EARNEST PARTNERS LLC | 1,654,287 | 88,554,000 | 4.31% | ||
| 7 | DIMENSIONAL FUND ADVISORS LP | 1,624,082 | 86,937,000 | 4.23% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 1,157,652 | 61,969,000 | 3.02% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 1,086,153 | 58,142,000 | 2.83% | ||
| 10 | ALLIANCEBERNSTEIN L.P. | 1,047,214 | 56,057,000 | 2.73% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 770,722 | 41,257,000 | 2.01% | ||
| 12 | FRONTIER CAPITAL MANAGEMENT CO LLC | 727,041 | 38,919,000 | 1.89% | ||
| 13 | BANK OF AMERICA CORP /DE/ | 722,522 | 38,677,000 | 1.88% | ||
| 14 | PFM Health Sciences, LP | 703,513 | 37,659,000 | 1.83% | ||
| 15 | NEXT CENTURY GROWTH INVESTORS LLC | 657,608 | 35,201,000 | 1.71% | ||
| 16 | STATE STREET CORP | 643,828 | 34,464,000 | 1.68% | ||
| 17 | DEUTSCHE BANK AG\ | 584,036 | 31,261,000 | 1.52% | ||
| 18 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 564,822 | 30,235,000 | 1.47% | ||
| 19 | VICTORY CAPITAL MANAGEMENT INC | 555,044 | 29,712,000 | 1.45% | ||
| 20 | AMERIPRISE FINANCIAL INC | 514,776 | 27,557,000 | 1.34% | ||
| 21 | JPMORGAN CHASE & CO | 505,905 | 27,081,000 | 1.32% | ||
| 22 | FRED ALGER MANAGEMENT, LLC | 494,591 | 26,475,000 | 1.29% | ||
| 23 | FMR LLC | 473,520 | 25,348,000 | 1.23% | ||
| 24 | CHARTWELL INVESTMENT PARTNERS, LLC | 410,076 | 21,951,000 | 1.07% | ||
| 25 | NEW YORK STATE COMMON RETIREMENT FUND | 371,375 | 19,880,000 | 0.97% | ||
| 26 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 367,919 | 19,695,000 | 0.96% | ||
| 27 | THOMPSON SIEGEL & WALMSLEY LLC | 364,933 | 19,535,000 | 0.95% | ||
| 28 | NORTHERN TRUST CORP | 361,971 | 19,376,000 | 0.94% | ||
| 29 | Bank of New York Mellon Corp | 350,359 | 18,754,000 | 0.91% | ||
| 30 | Tekla Capital Management LLC | 347,901 | 18,623,000 | 0.91% | ||
| 31 | DECADE CAPITAL MANAGEMENT LLC | 310,000 | 16,594,000 | 0.81% | ||
| 32 | BNP PARIBAS FINANCIAL MARKETS | 303,165 | 16,228,422 | 0.79% | ||
| 33 | NOMURA HOLDINGS INC | 260,321 | 13,943,000 | 0.68% | ||
| 34 | PANAGORA ASSET MANAGEMENT INC | 258,352 | 13,830,000 | 0.67% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 241,617 | 12,934,000 | 0.63% | ||
| 36 | NORGES BANK | 225,528 | 12,073,000 | 0.59% | ||
| 37 | DALTON GREINER HARTMAN MAHER & CO | 225,317 | 12,061,000 | 0.59% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 223,141 | 11,944,000 | 0.58% | ||
| 39 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,000 | 10,706,000 | 0.52% | ||
| 40 | PRINCIPAL FINANCIAL GROUP INC | 196,052 | 10,494,000 | 0.51% | ||
| 41 | RENAISSANCE TECHNOLOGIES LLC | 183,150 | 9,804,000 | 0.48% | ||
| 42 | Hood River Capital Management LLC | 182,273 | 9,757,000 | 0.47% | ||
| 43 | WELLS FARGO & COMPANY/MN | 181,726 | 9,727,000 | 0.47% | ||
| 44 | BLUE JAY CAPITAL MANAGEMENT, LLC | 180,000 | 9,635,000 | 0.47% | ||
| 45 | MANAGED ACCOUNT ADVISORS LLC | 179,055 | 9,585,000 | 0.47% | ||
| 46 | Commonwealth Equity Services, Inc | 165,487 | 8,859,000 | 0.43% | ||
| 47 | RUSSELL FRANK CO/ | 159,725 | 8,528,000 | 0.42% | ||
| 48 | Invesco Ltd. | 140,824 | 7,538,000 | 0.37% | ||
| 49 | PALISADE CAPITAL MANAGEMENT, LP | 140,185 | 7,504,000 | 0.37% | ||
| 50 | CAPITAL FUND MANAGEMENT S.A. | 132,102 | 7,071,000 | 0.34% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
