| 1 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,679,111 |
8,849,000 |
18.88% |
|
|
| 2 |
Tekla Capital Management LLC |
1,650,000 |
8,696,000 |
18.55% |
|
|
| 3 |
J. Goldman & Co LP |
1,226,176 |
6,462,000 |
13.79% |
|
|
| 4 |
SENZAR ASSET MANAGEMENT, LLC |
819,600 |
4,319,000 |
9.22% |
|
|
| 5 |
Avoro Capital Advisors LLC |
800,000 |
4,216,000 |
9.00% |
|
|
| 6 |
SUFFOLK CAPITAL MANAGEMENT LLC |
614,293 |
3,237,000 |
6.91% |
|
|
| 7 |
Healthcare Value Capital, LLC |
421,000 |
2,219,000 |
4.73% |
|
|
| 8 |
PURA VIDA INVESTMENTS, LLC |
420,000 |
2,092,000 |
4.46% |
|
|
| 9 |
VANGUARD GROUP INC |
383,083 |
2,019,000 |
4.31% |
|
|
| 10 |
SABBY MANAGEMENT, LLC |
150,000 |
791,000 |
1.69% |
|
|
| 11 |
Leonard Capital Management, Inc. |
104,210 |
549,000 |
1.17% |
|
|
| 12 |
MORGAN STANLEY |
91,237 |
481,000 |
1.03% |
|
|
| 13 |
AMERIPRISE FINANCIAL INC |
81,004 |
427,000 |
0.91% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
71,100 |
374,000 |
0.80% |
|
|
| 15 |
ROYAL BANK OF CANADA |
65,000 |
343,000 |
0.73% |
|
|
| 16 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
46,126 |
243,000 |
0.52% |
|
|
| 17 |
BlackRock Fund Advisors |
43,523 |
229,000 |
0.49% |
|
|
| 18 |
US BANCORP \DE\ |
40,000 |
211,000 |
0.45% |
|
|
| 19 |
WELCH & FORBES LLC |
34,016 |
179,000 |
0.38% |
|
|
| 20 |
NORTHERN TRUST CORP |
28,773 |
152,000 |
0.32% |
|
|
| 21 |
Alyeska Investment Group, L.P. |
25,478 |
134,000 |
0.29% |
|
|
| 22 |
BlackRock Institutional Trust Company, N.A. |
21,188 |
112,000 |
0.24% |
|
|
| 23 |
MILLENNIUM MANAGEMENT LLC |
17,638 |
93,000 |
0.20% |
|
|
| 24 |
PRELUDE CAPITAL MANAGEMENT, LLC |
15,100 |
80,000 |
0.17% |
|
|
| 25 |
D.A. DAVIDSON & CO. |
12,000 |
63,000 |
0.13% |
|
|
| 26 |
Mount Lucas Management LP |
11,500 |
61,000 |
0.13% |
|
|
| 27 |
JPMORGAN CHASE & CO |
11,340 |
60,000 |
0.13% |
|
|
| 28 |
ARDSLEY ADVISORY PARTNERS LP |
10,000 |
53,000 |
0.11% |
|
|
| 29 |
GUPTA WEALTH MANAGEMENT LLC |
6,859 |
36,000 |
0.08% |
|
|
| 30 |
Edge Wealth Management LLC |
4,930 |
26,000 |
0.06% |
|
|
| 31 |
UBS Group AG |
3,868 |
20,000 |
0.04% |
|
|
| 32 |
BlackRock Investment Management, LLC |
2,957 |
16,000 |
0.03% |
|
|
| 33 |
Tower Research Capital LLC (TRC) |
1,742 |
9,000 |
0.02% |
|
|
| 34 |
ClariVest Asset Management LLC |
1,514 |
8,000 |
0.02% |
|
|
| 35 |
MAGEE THOMSON INVESTMENT PARTNERS LLC |
1,074 |
5,000 |
0.01% |
|
|
| 36 |
FineMark National Bank & Trust |
150 |
1,000 |
0.00% |
|
|
| 37 |
DEUTSCHE BANK AG\ |
300 |
1,000 |
0.00% |
|
|
| 38 |
WELLS FARGO & COMPANY/MN |
228 |
1,000 |
0.00% |
|
|
