| 1 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,677,546 |
5,318,000 |
17.89% |
|
|
| 2 |
Tekla Capital Management LLC |
1,650,000 |
5,231,000 |
17.59% |
|
|
| 3 |
J. Goldman & Co LP |
1,185,676 |
3,759,000 |
12.64% |
|
|
| 4 |
SENZAR ASSET MANAGEMENT, LLC |
921,646 |
2,921,618 |
9.83% |
|
|
| 5 |
Avoro Capital Advisors LLC |
850,000 |
2,695,000 |
9.06% |
|
|
| 6 |
SUFFOLK CAPITAL MANAGEMENT LLC |
684,593 |
2,170,000 |
7.30% |
|
|
| 7 |
PURA VIDA INVESTMENTS, LLC |
523,000 |
1,658,000 |
5.58% |
|
|
| 8 |
Healthcare Value Capital, LLC |
421,000 |
1,335,000 |
4.49% |
|
|
| 9 |
VANGUARD GROUP INC |
399,875 |
1,268,000 |
4.26% |
|
|
| 10 |
SABBY MANAGEMENT, LLC |
330,128 |
1,047,000 |
3.52% |
|
|
| 11 |
MORGAN STANLEY |
92,244 |
292,000 |
0.98% |
|
|
| 12 |
ROYAL BANK OF CANADA |
85,017 |
270,000 |
0.91% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
80,845 |
256,000 |
0.86% |
|
|
| 14 |
AMERIPRISE FINANCIAL INC |
77,850 |
247,000 |
0.83% |
|
|
| 15 |
BlackRock Fund Advisors |
46,491 |
147,000 |
0.49% |
|
|
| 16 |
US BANCORP \DE\ |
40,000 |
127,000 |
0.43% |
|
|
| 17 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
39,900 |
126,000 |
0.42% |
|
|
| 18 |
WELCH & FORBES LLC |
34,016 |
108,000 |
0.36% |
|
|
| 19 |
NORTHERN TRUST CORP |
30,341 |
96,000 |
0.32% |
|
|
| 20 |
Alyeska Investment Group, L.P. |
28,044 |
89,000 |
0.30% |
|
|
| 21 |
BlackRock Institutional Trust Company, N.A. |
25,547 |
81,000 |
0.27% |
|
|
| 22 |
PRELUDE CAPITAL MANAGEMENT, LLC |
22,500 |
71,000 |
0.24% |
|
|
| 23 |
Mount Lucas Management LP |
17,000 |
54,000 |
0.18% |
|
|
| 24 |
D.A. DAVIDSON & CO. |
17,000 |
53,000 |
0.18% |
|
|
| 25 |
RENAISSANCE TECHNOLOGIES LLC |
15,900 |
50,000 |
0.17% |
|
|
| 26 |
MILLENNIUM MANAGEMENT LLC |
13,485 |
43,000 |
0.14% |
|
|
| 27 |
Bank of New York Mellon Corp |
13,095 |
42,000 |
0.14% |
|
|
| 28 |
JPMORGAN CHASE & CO |
10,998 |
35,000 |
0.12% |
|
|
| 29 |
BOOTHBAY FUND MANAGEMENT, LLC |
10,242 |
32,000 |
0.11% |
|
|
| 30 |
Tower Research Capital LLC (TRC) |
10,134 |
32,000 |
0.11% |
|
|
| 31 |
GUPTA WEALTH MANAGEMENT LLC |
6,859 |
22,000 |
0.07% |
|
|
| 32 |
Chicago Partners Investment Group LLC |
6,453 |
20,000 |
0.07% |
|
|
| 33 |
Edge Wealth Management LLC |
4,930 |
16,000 |
0.05% |
|
|
| 34 |
BlackRock Investment Management, LLC |
3,355 |
11,000 |
0.04% |
|
|
| 35 |
ClariVest Asset Management LLC |
1,514 |
5,000 |
0.02% |
|
|
| 36 |
MAGEE THOMSON INVESTMENT PARTNERS LLC |
1,230 |
4,000 |
0.01% |
|
|
| 37 |
UBS Group AG |
228 |
1,000 |
0.00% |
|
|
| 38 |
WELLS FARGO & COMPANY/MN |
428 |
1,000 |
0.00% |
|
|
| 39 |
CITIGROUP INC |
40 |
0 |
0.00% |
|
|
